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1.
Reumatismo ; 59(3): 240-3, 2007.
Article in Italian | MEDLINE | ID: mdl-17898885

ABSTRACT

Renal amyloidosis is a complication of ankylosing spondylitis. A possible pathogenetic role is due to TNF-alpha, with a direct action on glomerular receptors TNFR2 and renal injury, secondary to deposition of amyloid fibrils. The most frequent clinical manifestation is proteinuria or nephrotic syndrome. Etanercept, a soluble receptor of TNF-alpha, binds this circulant cytokine with a progressive improvement of renal function and reduction of deposits of amyloid. Transient leukopenia, observed during ankylosing spondylitis, should not be considered a controindication to the use of Etanercept, but it requires a constant monitoring. The benefit observed in our patient can represent an indication to the use of Etanercept for the management of amyloidosis.


Subject(s)
Amyloidosis/drug therapy , Immunoglobulin G/therapeutic use , Receptors, Tumor Necrosis Factor/therapeutic use , Spondylitis, Ankylosing/complications , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Aged , Amyloidosis/diagnosis , Amyloidosis/etiology , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Drug Therapy, Combination , Etanercept , Humans , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/therapeutic use , Indomethacin/administration & dosage , Indomethacin/therapeutic use , Male , Methotrexate/administration & dosage , Methotrexate/therapeutic use , Methylprednisolone/administration & dosage , Methylprednisolone/therapeutic use , Proteinuria/etiology , Serum Amyloid A Protein/analysis , Spondylitis, Ankylosing/diagnosis
2.
Scand J Rheumatol ; 32(3): 186-8, 2003.
Article in English | MEDLINE | ID: mdl-12892259

ABSTRACT

Psoriasis is rarely associated with systemic sclerosis (SSc), and sacroiliitis associated to Connective Tissue Diseases is also rather rare. In this report we describe a case of a young woman with SSc who developed symptomatic and bilateral sacroiliitis. The clinical pattern of sacroiliac involvement of this patient resembles that of psoriatic sacroiliitis. HLA typing was compatible with both SSc and psoriasis. Psoriatic sacroiliitis could not be diagnosed, but, on the basis of these observations, the patient described could represent a case of PsA without psoriasis. and psoriatic cutaneous involvement masked by the presence of SSc.


Subject(s)
Bone Diseases/pathology , Psoriasis/diagnosis , Sacroiliac Joint/pathology , Scleroderma, Systemic/diagnosis , Adult , Bone Diseases/etiology , Diagnosis, Differential , Female , Histocompatibility Testing , Humans , Psoriasis/pathology , Scleroderma, Systemic/pathology
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