[Successful treatment of superior mesenteric artery thrombosis with local high-dose urokinase therapy]. / Erfolgreiche Behandlung einer Thrombose der Arteria mesenterica superior durch lokale, hochdosierte Urokinasetherapie.

A 56 year old man presented with increasing abdominal pain. He suffered from arterial occlusive disease with occlusion of the right A. iliaca communis. Angiography revealed partial thrombotic occlusion of the superior mesenteric artery. Urokinase (UK) at a dose of 150 IU/kg X minutes and heparin (1,000 U/h) was infused through the 7F angiographic catheter for 180 minutes. After 70 min of treatment, angiography showed improvement, and after 120 min the thrombus was nearly completely lysed. A stenosis of approximately 50% was still present after 180 min. Two hours after treatment the patient was pain free without analgesics. Laboratory studies showed systemic fibrinogenolysis, but fibrinogen was still within the upper normal range. Only slight systemic fibrinolytic activity (less than 5 IU UK/ml) could be determined. However, alpha 2-antiplasmin was depleted. The catheter was drawn 15 h after thrombolysis without bleeding. While under concurrent heparin and phenprocoumon therapy, the patient developed an infected gluteal hematoma as a result of i.m. injections prior to this treatment. A repeat angiography approximately one month after thrombolysis revealed further improvement and patency. The patient is well and free of abdominal angina and under oral anticoagulant therapy.

[Therapy in cancer of the male breast (author's transl)]. / Zur Therapie des mämmlichen Mammakarzinoms.

Six patients with carcinomas of the breast are reported. Bienergetic pendulum irradiation with electrons is applied following surgical treatment in the same manner as with female patients. The possibilities of metastasition treatment are discussed.