Combined ionized calcium and PTH evaluation in the management of post-thyroidectomy hypocalcemia.

BACKGROUND: The aim of our study was to investigate the postoperative course of calcium and parathyroid hormone (PTH) levels after total thyroidectomy to define a proper and low cost protocol. METHODS: We studied 144 patients who underwent total thyroidectomy between 2007 and 2010. Ionized calcium was determined preoperatively and on day 1 (POD1), day 2 (POD2) and day 7 (POD7) postoperatively; PTH preoperatively and on POD7. Patients with ionized calcium ≤1.11 mmol/L were considered hypocalcemic and treated only if symptoms, ≤1 mmol/L were treated in all cases. RESULTS: Ionized calcium and PTH declined postoperative in all patients compared to preoperative levels (P=0.000). Ionized calcium increased on POD7 compared to POD1 and POD2 (P=0.000). All hypocalcemic untreated 30 patients returned normocalcemic on POD7. Thirty-eight hypocalcemic patients were treated but 23 (61%) safely suspended therapy on POD7. We tested PTH and ionized calcium as independent factors of prolonged hypocalcemia (that required therapy beyond 7 days) with the following results (sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy): PTH ≤11 pg/mL (80%, 100%, 100%, 96% and 97%, respectively), ionized calcium ≤1.11 mmol/L (80%, 88%, 59%, 95%, and 87%, respectively) and ionized calcium ≤1 mmol/L (28%, 100%, 100%, 87% and 88%, respectively). CONCLUSIONS: Our data show that our protocol, including serum ionized calcium on 1st, 2nd, 7th days and PTH on 7th day after surgery, is safe and low cost and therefore may be useful in the post-surgical management of total thyroidectomy.

Biocompatibility versus peritoneal mesothelial cells of polypropylene prostheses for hernia repair, coated with a thin silica/silver layer.

Hernias are generally repaired using synthetic prostheses. Infection may already be present or develop during implantation. Based on the increasing resistance to antibiotics, and the well-known antimicrobial properties of silver (Ag), the possibility of coating hernia prostheses with a nanostructured layer containing Ag was explored. Prostheses (Clear Mesh Composite [CMC]) made up of two polypropylene layers (macroporous light mesh and thin transparent film) were tested with human mesothelial cells from omentum biopsies. Mesotheliocytes modulate abdominal wall healing producing cytokines, growth factors, and adhesion molecules. Evaluating the growth of these cells on CMC or film alone showed that cell numbers on CMC increased over time, and were higher than those on film alone. Vimentin immunostaining confirmed the cells to be mesotheliocytes. Subsequently, the biocompatibility of mesh layer, coated or not with a thin layer of Ag/SiO2 -nanoclusters, was analyzed, showing no difference in absence or presence of Ag/SiO2 . Differently, TGF-ß2 production, involved in tissue repair and fibrosis, increased in the presence of Ag/SiO2 . Moreover, Ag/SiO2 -coated mesh showed antibacterial properties. In conclusion, the mesh layer coated with Ag/SiO2 afforded cell growth, and showed antibacterial activity. Coating only the mesh layer did not decrease film transparency, and did not favor the formation of adhesions on the visceral side. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1586-1593, 2017.

Possible impact of autologous blood towards elective open and laparoscopic surgery for colorectal carcinoma.

BACKGROUND/AIMS: An alternative approach to the allogeneic transfusion is patient's blood collection before the operation, using or not using the human recombinant erythropoietin. The aim of this study is to evaluate the percentage of people undergoing an elective operation for colorectal carcinoma who could avoid allogeneic blood due to blood predonation. METHODOLOGY: From January 1999 to April 2002, 249 patients (140 males and 109 females) underwent an operation for colorectal cancer. The most important parameter, used to estimate which patients are candidates for autologous blood predonation, is the before-treatment hemoglobin level. The other parameters we considered are the age of the patient, the absence of uncontrolled hypertension or clinically significant pathologies (except colorectal cancer), and the iron shortage. DESIGN: Retrospective cohort study. RESULTS: 36.5% of the patients satisfied every criterion to begin autologous predonation without using the human recombinant erythropoietin; instead, 23.7% of patients needed the administration of the human recombinant erythropoietin and additional iron. The valuation of the transfusional prospects, based on sex and cancer location is very interesting. CONCLUSIONS: Autologous blood predeposit in preoperational time turns out to be a method of increasing importance, thanks to the human recombinant erythropoietin.

[Recurrent groin hernia: a cognitive survey in Piedmont]. / Ernia inguinale recidiva: indagine conoscitiva in Piemonte.

The aim of this study was to analyze, using a cognitive survey, how recurrent groin hernia are treated in our region by surgical centres. A form was sent to 49 surgical centres in our region, considering the period 2002 -first six months of 2004, asking the number of primitive hernias treated, surgical technique, number of recurrent hernias treated, surgical technique, kind of anaesthesia and types of complications. We sent 49 forms, 41 (83.7%) were given back. During the considered period, 18 580 primitive hernias and 1102 recurrent (5.6% of all repair) were treated. The greatest part of it was performed with an open mesh technique tension free (77% of primitive hernias, and 62% of recurrent ones). Laparoscopic repair was performed in 0.2% of primitive hernias and 3.2% of recurrent ones. The operations were carried out mainly in spinal anaesthesia (722, 65.5%). Recurrence occurred in 34 cases (3.1%). In our region inguinal hernia repair both for primitive and recurrent groin hernia has been performed mainly by an open mesh technique, tension free and sutureless and, in greatest part, in spinal anaesthesia. Laparoscopic repair has not been used very much.