1.
Biopharm Drug Dispos
; 12(2): 163-9, 1991 Mar.
Article
in English
| MEDLINE
| ID: mdl-1851646
ABSTRACT
The disposition of disulfiram after administration in a new formulation was studied in rats and alcoholic patients. The suspension consisted of microcrystals suspended in a mixture of propylene glycol and water and injected subcutaneously into rats and humans; the course of the plasma concentration of diethyldithiocarbamate with time was followed by gas-liquid chromatography. Systemic delivery of disulfiram was observed to occur for a month. The data demonstrate that this form has the properties of a sustained-release formulation when implanted subcutaneously. There was no evidence of local or systemic adverse reactions.
Subject(s)
Alcoholism/metabolism , Disulfiram/pharmacokinetics , Adult , Animals , Delayed-Action Preparations , Disulfiram/administration & dosage , Ditiocarb/metabolism , Female , Humans , Male , Rats , Rats, Inbred Strains
2.
Rev Med Chil
; 116(11): 1119-23, 1988 Nov.
Article
in Spanish
| MEDLINE
| ID: mdl-3267896
3.
Rev Med Chil
; 113(12): 1188-93, 1985 Dec.
Article
in Spanish
| MEDLINE
| ID: mdl-3837303
4.
Rev Med Chil
; 110(11): 1071-4, 1982 Nov.
Article
in Spanish
| MEDLINE
| ID: mdl-6820827
Subject(s)
Alcoholism/drug therapy , Lithium/therapeutic use , Ambulatory Care , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Lithium Carbonate , Male , Patient Dropouts , Recurrence
5.
Rev Med Chil
; 110(1): 61-6, 1982 Jan.
Article
in Spanish
| MEDLINE
| ID: mdl-7156550
Subject(s)
Alcoholism/psychology , Ambulatory Care , Adult , Alcoholism/therapy , Chile , Female , Hospitals, General , Humans , Male , Mental Disorders/complications , Middle Aged , Outpatient Clinics, Hospital , Socioeconomic Factors
6.
Rev. méd. Chile
; 110(1): 61-6, 1982.
Article
in Spanish
| LILACS
| ID: lil-7591
7.
Rev. méd. Chile
; 110(11): 1071-4, 1982.
Article
in Spanish
| LILACS
| ID: lil-12253
