ABSTRACT
Primary central nervous system lymphomas and anaplastic oligodendrogliomas are not uncommon; however, no association between the 2 has been documented to date. We describe a unique case, whereby a patient presenting with seizures and slight impairment of higher functions, underwent frontal lobectomy for a mass lesion. The histology revealed dual pathology of anaplastic oligodendroglioma and B cell non-Hodgkin lymphoma. Postoperatively, the patient received whole brain radiotherapy. The patient remained well after 18 months of follow-up with no radiological progression of a known tumor residuum.
Subject(s)
Brain Neoplasms/pathology , Lymphoma, B-Cell/pathology , Neoplasms, Multiple Primary/pathology , Oligodendroglioma/pathology , Brain Neoplasms/diagnostic imaging , Brain Neoplasms/radiotherapy , Brain Neoplasms/surgery , Frontal Lobe/diagnostic imaging , Frontal Lobe/pathology , Frontal Lobe/surgery , Humans , Lymphoma, B-Cell/diagnostic imaging , Lymphoma, B-Cell/radiotherapy , Lymphoma, B-Cell/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasms, Multiple Primary/diagnostic imaging , Neoplasms, Multiple Primary/radiotherapy , Neoplasms, Multiple Primary/surgery , Oligodendroglioma/diagnostic imaging , Oligodendroglioma/radiotherapy , Oligodendroglioma/surgery , Paresis/etiology , Psychosurgery , Seizures/etiology , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
OBJECT: A long-term prospective analysis of patients with benign meningioma was undertaken to determine whether progesterone receptor (PR) status of the excised tumor has any influence on recurrence. METHODS: Between 1983 and 1985, a total of 62 meningiomas in 53 patients (age range 19-79 years, mean age 55.6 years) were studied for clinical, histological, and pathological characteristics, including hormone receptor status and DNA features. Progesterone receptor status was quantified by cryostat section assay, and then factors affecting recurrence were analyzed. During 1997 all case records were reviewed to determine whether tumor had recurred in any patient, and PR status was correlated with tumor recurrence. Of the 62 tumors, 60 were benign, and of the benign tumors 29 (48%) were PR positive. Patients harboring 14 of the 60 benign tumors were lost to follow up. Of the 46 tumors included in the final analysis, 13 were recurrent (all within 5 years) and 33 were nonrecurrent. Of the 33 nonrecurrent tumors, 14 had not recurred 5 to 10 years postresection and 19 had not recurred after more than 10 years. Chi-square analysis of the results did not show an association between recurrence and patient's sex, extent of resection, histological subtype, or tumor site but did show an association between recurrence and PR negativity (p = 0.013). CONCLUSIONS: The results indicate that benign meningiomas that are PR positive are less likely to recur, a finding that has prognostic and therapeutic implications.
