Congruence in European and Asian perception of Vietnamese facial attractiveness, averageness, symmetry and sexual dimorphism.

Attractiveness is a proposed universal cue to overall biological quality. Nonetheless, local raters and raters of the same ethnicity may be more accurate in assessing the cues for attractiveness than distant and unfamiliar raters. Shared ethnicity and shared environment may both affect rating accuracy: our aim was to compare their relative influence. Therefore, we photographed young Vietnamese participants (N = 93, 33 women) from Hanoi, Vietnam. The photographs were rated by Czechs, Asian Vietnamese, and Czech Vietnamese (raters of Vietnamese origin who lived in Czechia for all or most of their life). Using geometric morphometrics, we measured facial shape cues to biological quality: averageness, asymmetry, and sexual dimorphism. We expected that Vietnamese raters residing in Czechia and Vietnam would agree on perceived attractiveness and use shape-related facial cues to biological quality better than Czech European raters, who are less familiar with East Asians. Surprisingly, mixed-effect models and post hoc comparisons identified no major cross-group differences in attributed attractiveness and path analyses revealed that the three groups based their rating on shape-related characteristics in a similar way. However, despite the considerable cross-cultural agreement regarding perceived attractiveness, Czech European raters associated attractiveness with facial shape averageness significantly more than Vietnamese raters.

Serum Thymidine Kinase 1 - Potential Prostate Cancer Biomarker: A Clinical Study.

BACKGROUND/AIM: Serum thymidine kinase 1 (STK1) is a proliferation biomarker that has been used as a diagnostic marker of several malignant diseases. However, there are limited data for prostate cancer (PCa). PATIENTS AND METHODS: In this study, we retrospectively analysed serum samples from 169 patients with biopsy confirmed PCa, who had been indicated for radical prostatectomy (RP) between 2013-2016. The results were compared with those in serum samples from 39 healthy men. We used commercially available enzymatic immunoassay to determine the levels of STK1. The patients were divided into groups according to the Gleason score (GS) and risk factors for adjuvant radiotherapy (aRT), which were defined as GS 8-10, pT3, and a positive surgical margin. RESULTS: The median serum level of STK1 in PCa patients was 0.289 pmol/l. In the control group, the median value was 0.0116 pmol/l (p<0.001). By comparing the patients with GS≤6 vs. 7 vs. ≥8 (p=0.01), we found statistically significant differences. In the correlation of STK1 values with risk factors, we found statistically significant differences both in comparison of 0 vs. 1 vs. 2 vs. 3 risk factors (p=0.021), as well as ≤1 vs. 2≥ risk factors (p=0.009). CONCLUSION: The levels of STK1 are significantly higher in patients with PCa than those in healthy controls. Furthermore, STK1 values correlate with GS and predefined risk factors for aRT. Therefore, STK1 can be considered as a potential tumour marker of PCa diagnosis and risk stratification.

Redheaded women are more sexually active than other women, but it is probably due to their suitors.

Women with red hair color, i.e., 1-9% of female Europeans, tend to be the subject of various stereotypes about their sexually liberated behavior. The aim of the present case-control study was to explore whether a connection between red hair color and sexual behavior really exists using data from 110 women (34% redheaded) and 93 men (22% redheaded). Redheadedness in women, correlated with various traits related to sexual life, namely with higher sexual desire as measured by Revised Sociosexual Orientation Inventory, with higher sexual activity and more sexual partners of the preferred gender over the past year, earlier initiation of sexual life, and higher sexual submissiveness. Structural equation modelling, however, showed that sexual desire of redheaded women mediated neither their higher sexual activity nor their higher number of sexual partners. These results indirectly indicate that the apparently more liberated sexual behavior in redheaded women could be the consequence of potential mates' frequent attempts to have sex with them. Our results contradicted the three other tested models, specifically the models based on the assumption of different physiology, faster life history strategy, and altered self-perception of redheaded women induced by stereotypes about them. Naturally, the present study cannot say anything about the validity of other potential models that were not subjects of testing.

Lordosis in Humans.

Despite progress in attractiveness research, we have yet to identify many fitness-relevant cues in the human phenotype or humans' psychology for responding to them. Here, we test hypotheses about psychological systems that may have evolved to process distinct cues in the female lumbar region. The Fetal Load Hypothesis proposes a male preference for a morphological cue: lumbar curvature. The Lordosis Detection Hypothesis posits context-dependent male attraction to a movement: lordosis behavior. In two studies (Study 1 N: 102, Study 2 N: 231), we presented men with animated female characters that varied in their lumbar curvature and back arching (i.e., lordosis behavior). Irrespective of mating context, men's attraction increased as lumbar curvature approached the hypothesized optimum. By contrast, men experienced greater attraction to lordosis behavior in short-term than long-term mating contexts. These findings support both the Lordosis Detection and Fetal Load Hypotheses. Discussion focuses on the meaning of human lordosis and the importance of dynamic stimuli in attractiveness research.

The safety of neoadjuvant hormonal treatment in infants with cryptorchidism.

BACKGROUND/PURPOSE: The standard treatment for boys with non-syndromic cryptorchidism is an early orchidopexy. It is unclear if surgical intervention alone is enough for future fertility. Recent studies show benefit of neoadjuvant or adjuvant hormonal treatment with gonadorelin (GnRH) for spermatogonia maturation based on testicular biopsy. The aim of this prospective study was to assess the safety of this treatment in infants with undescended testis at the recommended timing of early gonadorelin administration and timing of orchidopexy. METHODS: Unilateral cryptorchid full term boys were initially examined (including hormonal, physical and ultrasound examination) at the age of 2.5-3.5 months. At 6 months of age, cryptorchidism was confirmed. Those with non-syndromic cryptorchidism and palpable or sonographically detected testis were randomly assigned into two groups: with and without intranasal gonadorelin treatment. Inclusion criteria were met by 36 boys (21 in GNRH and 15 in the control groups). The following orchidopexy was performed before 12 months of age with repeated examination at time of surgery. Penile size and testicular volume (using ultrasound) and basal serum levels of LH, FSH, testosterone, Inhibin B and AMH were recorded at age of 3.0 (mean) months and 11.0 (mean) months (date of surgery). The stimulation hormonal levels were checked during GnRH administration. RESULTS: Between minipuberty (mean 3 months) and time of orchidopexy (mean 11 months of age) the penile size increased significantly and similarly in both groups. There was no significant difference in the change of the volume of descended testis between the groups nor of the volume of undescended testis. In addition, we did not find any significant difference in the change (drop) of hormonal levels of LH, FSH, Testosterone, Inhibin B and AMH (Table 1a) CONCLUSION: The neoadjuvant gonadorelin stimulation in infants with unilateral undescended testis has not shown any specific effect on the development of penile size, testicular volume and hormonal levels at time of orchidopexy in comparison with boys without stimulation, and in the mid-term, this treatment can be considered safe. Further follow-up is necessary to evaluate the long-term effect of this early treatment.

Africans and Europeans differ in their facial perception of dominance and sex-typicality: a multidimensional Bayesian approach.

Biosocial impact of facial dominance and sex-typicality is well-evidenced in various human groups. It remains unclear, though, whether perceived sex-typicality and dominance can be consistently predicted from sexually dimorphic facial features across populations. Using a combination of multidimensional Bayesian approach and geometric morphometrics, we explored associations between perceived dominance, perceived sex-typicality, measured sexual shape dimorphism, and skin colour in a European and an African population. Unlike previous studies, we investigated the effect of facial variation due to shape separately from variation due to visual cues not related to shape in natural nonmanipulated stimuli. In men, perceived masculinity was associated with perceived dominance in both populations. In European women higher perceived femininity was, surprisingly, likewise positively associated with perceived dominance. Both shape and non-shape components participate in the constitution of facial sex-typicality and dominance. Skin colour predicted perceived sex-typicality in Africans but not in Europeans. Members of each population probably use different cues to assess sex-typicality and dominance. Using our methods, we found no universal sexually dimorphic scale predicting human perception of sex-typicality and dominance. Unidimensional understanding of sex-typicality thus seems problematic and should be applied with cautions when studying perceived sex-typicality and its correlates.

Predicting strength from aggressive vocalizations versus speech in African bushland and urban communities.

The human voice carries information about a vocalizer's physical strength that listeners can perceive and that may influence mate choice and intrasexual competition. Yet, reliable acoustic correlates of strength in human speech remain unclear. Compared to speech, aggressive nonverbal vocalizations (roars) may function to maximize perceived strength, suggesting that their acoustic structure has been selected to communicate formidability, similar to the vocal threat displays of other animals. Here, we test this prediction in two non-WEIRD African samples: an urban community of Cameroonians and rural nomadic Hadza hunter-gatherers in the Tanzanian bushlands. Participants produced standardized speech and volitional roars and provided handgrip strength measures. Using acoustic analysis and information-theoretic multi-model inference and averaging techniques, we show that strength can be measured from both speech and roars, and as predicted, strength is more reliably gauged from roars than vowels, words or greetings. The acoustic structure of roars explains 40-70% of the variance in actual strength within adults of either sex. However, strength is predicted by multiple acoustic parameters whose combinations vary by sex, sample and vocal type. Thus, while roars may maximally signal strength, more research is needed to uncover consistent and likely interacting acoustic correlates of strength in the human voice. This article is part of the theme issue 'Voice modulation: from origin and mechanism to social impact (Part I)'.

Environmental convergence in facial preferences: a cross-group comparison of Asian Vietnamese, Czech Vietnamese, and Czechs.

It has been demonstrated that sociocultural environment has a significant impact on human behavior. This contribution focuses on differences in the perception of attractiveness of European (Czech) faces as rated by Czechs of European origin, Vietnamese persons living in the Czech Republic and Vietnamese who permanently reside in Vietnam. We investigated whether attractiveness judgments and preferences for facial sex-typicality and averageness in Vietnamese who grew up and live in the Czech Republic are closer to the judgements and preferences of Czech Europeans or to those of Vietnamese born and residing in Vietnam. We examined the relative contribution of sexual shape dimorphism and averageness to the perception of facial attractiveness across all three groups of raters. Czech Europeans, Czech Vietnamese, and Asian Vietnamese raters of both sexes rated facial portraits of 100 Czech European participants (50 women and 50 men, standardized, non-manipulated) for attractiveness. Taking Czech European ratings as a standard for Czech facial attractiveness, we showed that Czech Vietnamese assessments of attractiveness were closer to this standard than assessments by the Asian Vietnamese. Among all groups of raters, facial averageness positively correlated with perceived attractiveness, which is consistent with the "average is attractive" hypothesis. A marginal impact of sexual shape dimorphism on attractiveness rating was found only in Czech European male raters: neither Czech Vietnamese nor Asian Vietnamese raters of either sex utilized traits associated with sexual shape dimorphism as a cue of attractiveness. We thus conclude that Vietnamese people permanently living in the Czech Republic converge with Czechs of Czech origin in perceptions of facial attractiveness and that this population adopted some but not all Czech standards of beauty.

Facial attractiveness and preference of sexual dimorphism: A comparison across five populations.

Despite intensive research, evolutionary psychology has not yet reached a consensus regarding the association between sexual dimorphism and attractiveness. This study examines associations between perceived and morphological facial sexual dimorphism and perceived attractiveness in samples from five distant countries (Cameroon, Colombia, Czechia, Iran and Turkey). We also examined possible moderating effects of skin lightness, averageness, age, body mass and facial width. Our results suggest that in all samples, women's perceived femininity was positively related to their perceived attractiveness. Women found perceived masculinity in men attractive only in Czechia and Colombia, two distant populations. The association between perceived sexual dimorphism and attractiveness is thus potentially universal only for women. Across populations, morphological sexual dimorphism and averageness are not universally associated with either perceived facial sexual dimorphism or attractiveness. With our exploratory approach, results highlight the need for control of which measure of sexual dimorphism is used (perceived or measured) because they affect perceived attractiveness differently. Morphological averageness and sexual dimorphism are not good predictors of perceived attractiveness. It is noted that future studies should use samples from multiple populations to allow for identification of specific effects of local environmental and socioeconomic conditions on preferred traits in unmanipulated local facial stimuli.

The predictive value of the prostate health index vs. multiparametric magnetic resonance imaging for prostate cancer diagnosis in prostate biopsy.

PURPOSE: To compare the ability of Prostate Health Index (PHI) to diagnose csPCa, with that of total PSA, PSA density (PSAD) and the multiparametric magnetic resonance (mpMRI) of the prostate. METHODS: We analysed a group of 395 men planned for a prostate biopsy who underwent a mpMRI of the prostate evaluated using the PIRADS v1 criteria. All patients had their PHI measured before prostate biopsy. In patients with an mpMRI suspicious lesions, an mpMRI/ultrasound software fusion-guided biopsy was performed first, with 12 core systematic biopsy performed in all patients. A ROC analysis was performed for PCa detection for total PSA, PSAD, PIRADS score and PHI; with an AUC curve calculated for all criteria and a combination of PIRADS score and PHI. Subsequent sub-analyses included patients undergoing first and repeat biopsy. RESULTS: The AUC for predicting the presence of csPCa in all patients was 59.5 for total PSA, 69.7 for PHI, 64.9 for PSAD and 62.5 for PIRADS. In biopsy naive patients it was 61.6 for total PSA, 68.9 for PHI, 64.6 for PSAD and 63.1 for PIRADS. In patients with previous negative biopsy the AUC for total PSA, PHI, PSAD and PIRADS was 55.4, 71.2, 64.4 and 69.3, respectively. Adding of PHI to PIRADS increased significantly (p = 0.007) the accuracy for prediction of csPCa. CONCLUSION: Prostate Health Index could serve as a tool in predicting csPCa. When compared to the mpMRI, it shows comparable results. The PHI cannot, however, help us guide prostate biopsies in any way, and its main use may, therefore, be in pre-MRI or pre-biopsy triage.

Preoperative prostate health index predicts adverse pathology and Gleason score upgrading after radical prostatectomy for prostate cancer.

BACKGROUND: We aimed to explore the utility of prostate specific antigen (PSA) isoform [- 2] proPSA and its derivatives for prediction of pathological outcome after radical prostatectomy (RP). METHODS: Preoperative blood samples were prospectively and consecutivelyanalyzed from 472 patients treated with RP for clinically localized prostate cancerat four medical centers. Measured parameters were PSA, free PSA (fPSA), fPSA/PSA ratio, [- 2] proPSA (p2PSA), p2PSA/fPSA ratio and Prostate Health Index (PHI)(p2PSA/fPSA)*√PSA]. Logistic regression models were fitted to determine the accuracy of markers for prediction of pathological Gleason score (GS) ≥7, Gleason score upgrading, extracapsular extension of the tumor (pT3) and the presence of positive surgical margin (PSM). The accuracy of predictive models was compared using area under the receiver operating curve (AUC). RESULTS: Of 472 patients undergoing RP, 339 (72%) were found to have pathologic GS ≥ 7, out of them 178 (53%) experienced an upgrade from their preoperative GS = 6. The findings of pT3 and PSM were present in 132 (28%) and 133 (28%) cases, respectively. At univariable analysis of all the preoperative parameters, PHI was the most accurate predictor of pathological GS ≥7 (OR 1.02, 95% CI 1.01-1.03, p<0.001), GS upgrading (OR 1.02, 95% CI 1.01-1.03, p<0.003), pT3 disease (OR 1.01, 95% CI 1.00-1.02, p<0.007) and the presence of PSM (OR 1.01, 95% CI 1.00-1.02, p<0.002). Adding of PHI into the base multivariable model increased significantly the accuracy for prediction of pathological GS by 4.4% to AUC = 66.6 (p = 0.015) and GS upgrading by 5.0% to AUC = 65.9 (p = 0.025), respectively. CONCLUSIONS: Preoperative PHI levels may contribute significantly to prediction of prostate cancer aggressiveness and expansion of the tumor detected at final pathology.

Increased 25(OH)D3 level in redheaded people: Could redheadedness be an adaptation to temperate climate?

About 1-2% of European population are redheaded, meaning they synthesize more pheomelanin than eumelanin, the main melanin pigment in humans. Several mutations could be responsible for this phenotype. It has been suggested that corresponding mutations spread in Europe due to a founder effect shaped either by a relaxation of selection for dark, UV-protective phenotypes or by sexual selection in favour of rare phenotypes. In our study, we investigated the levels of vitamin D precursor 25(OH)D3 (calcidiol) and folic acid in the blood serum of 73 redheaded and 130 non-redheaded individuals. In redheaded individuals, we found higher 25(OH)D3 concentrations and approximately the same folic acid concentrations as in non-redheaded subjects. 25(OH)D3 concentrations correlated with the intensity of hair redness measured by two spectrophotometric methods and estimated by participants themselves and by independent observers. In non-redheaded individuals, 25(OH)D3 levels covaried with the amount of sun exposure and intensity of suntan while in redheaded individuals, this was not the case. It suggests that increased 25(OH)D3 levels in redheaded individuals are due to differences in physiology rather than in behaviour. We also found that folic acid levels increased with age and the intensity of baldness and decreased with the frequency of visiting tanning salons. Our results suggest that the redheaded phenotype could be an evolutionary adaptation for sufficient photosynthesis of provitamin D in conditions of low intensity of UVB radiation in central and northern parts of Europe.

Unstented laparoscopic pyeloplasty in young children (1-5 years old): a comparison with a repair using double-J stent or transanastomotic externalized stent.

OBJECTIVE: To evaluate feasibility of unstented laparoscopic pyeloplasty in young children to prevent pyelonephritis and second anaesthesia. PATIENTS AND METHODS: During 2006-2013, 70 children (1-5 years old) underwent laparoscopic pyeloplasty for high grade hydronephrosis. Unstented repair was indicated in 34 children (GroupL1), double-J stent was placed in 21 patients (Group L2) and uretero-pyelostomy stent (Cook) in 15 patients (Group L3). Stenting was preferred in large thin-walled pelvis, thin ureter, kidney malrotation, and unfavourable course of crossing vessels. The outcome was compared with age-matched group of 52 children who had open surgery during 1996-2006 (Groups O1, O3). RESULTS: Operation times were significantly shorter in Groups L1 and L2 than in Group L3; the times were shorter in open repairs. Three patients with crossing vessels from Group L1 had urine leakage and one had obstruction (11.4%). In Group L2, one patient had obstruction, one incorrect placement of the stent, and one girl had serious pyelonephritis (14.3%). In Group L3, displacement of uretero-pyelostomy occurred in one patient (6.7%). There is no statistical difference between laparoscopic groups and between laparoscopic and open groups. CONCLUSION: Unstented laparoscopic pyeloplasty is a safe procedure in selected young children with favourable anatomical conditions preventing additional anaesthesia and stent-related complications.