Subject(s)
Humans , Female , Adult , Allergens/adverse effects , Anemia, Hemolytic/diagnosis , Antineoplastic Agents/adverse effects , Carboplatin/adverse effects , Carcinoma, Papillary/drug therapy , Desensitization, Immunologic/methods , Drug Hypersensitivity/diagnosis , Drug-Related Side Effects and Adverse Reactions/diagnosis , Ovarian Neoplasms/drug therapy , Plasma Exchange/methods , Anemia, Hemolytic/etiology , Antineoplastic Agents/therapeutic use , Carboplatin/therapeutic use , Desensitization, Immunologic/adverse effects , Drug-Related Side Effects and Adverse Reactions/therapySubject(s)
Allergens/adverse effects , Anemia, Hemolytic/diagnosis , Antineoplastic Agents/adverse effects , Carboplatin/adverse effects , Carcinoma, Papillary/drug therapy , Desensitization, Immunologic/methods , Drug Hypersensitivity/diagnosis , Drug-Related Side Effects and Adverse Reactions/diagnosis , Ovarian Neoplasms/drug therapy , Plasma Exchange/methods , Adult , Anemia, Hemolytic/etiology , Anemia, Hemolytic/therapy , Antineoplastic Agents/therapeutic use , Carboplatin/therapeutic use , Desensitization, Immunologic/adverse effects , Drug Hypersensitivity/complications , Drug Hypersensitivity/therapy , Drug-Related Side Effects and Adverse Reactions/therapy , Female , Humans , Hypersensitivity, ImmediateABSTRACT
Summary: Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.
Subject(s)
Allergens/immunology , Clindamycin/immunology , Hypersensitivity, Delayed/diagnosis , Immunoassay/methods , Skin Tests/methods , Skin/pathology , T-Lymphocytes/immunology , Adolescent , Cell Transformation, Neoplastic , Drug Hypersensitivity/diagnosis , Female , Humans , Lymphocyte Activation , Male , Middle AgedSubject(s)
Humans , Female , Middle Aged , Urticaria/complications , Urticaria/diagnosis , Urticaria/therapy , Food Hypersensitivity/complications , Food Hypersensitivity/diagnosis , Food Hypersensitivity/drug therapy , Wheat Hypersensitivity/complications , Wheat Hypersensitivity/diagnosis , Wheat Hypersensitivity/drug therapy , Eriogonum/adverse effects , Triticum/adverse effects , Wheat Hypersensitivity/immunology , Wheat Hypersensitivity/prevention & control , Wheat Hypersensitivity/physiopathologyABSTRACT
Drug-related rash with eosinophilia and systemic symptoms (DRESS) syndrome, or drug-induced hypersensitivity syndrome (DIHS), is a life-threatening multiorgan systemic reaction characterized by rash, fever, lymphadenopathy, hepatitis, and leukocytosis with eosinophilia. Aromatic anticonvulsant drugs and allopurinol have been reported to be the most frequent eliciting agents. Our search of the literature revealed only 2 cases induced by piperacillin and 1 case by ceftriaxone.We present 2 cases of DRESS syndrome induced by the beta-lactam drugs ceftriaxone and piperacillin-tazobactam. An allergological workup including skin prick test, intradermal tests, patch tests, and lymphocyte transformation test (LTT) was performed. LTT was shown to be a useful technique in both cases to help to identify the drugs involved.
Subject(s)
Anticonvulsants/adverse effects , Ceftriaxone/adverse effects , Drug Hypersensitivity/diagnosis , beta-Lactams/adverse effects , Adrenal Cortex Hormones/administration & dosage , Adult , Anticonvulsants/administration & dosage , Anticonvulsants/pharmacology , Ceftriaxone/administration & dosage , Ceftriaxone/pharmacology , Cell Proliferation/drug effects , Cells, Cultured , Colitis, Ulcerative/drug therapy , Drug Hypersensitivity/drug therapy , Drug Hypersensitivity/immunology , Drug Hypersensitivity/physiopathology , Eosinophilia , Epilepsy/drug therapy , Exanthema , Female , Histamine Antagonists/administration & dosage , Humans , Lymphocyte Activation/drug effects , Male , Penicillanic Acid/administration & dosage , Penicillanic Acid/adverse effects , Penicillanic Acid/analogs & derivatives , Penicillanic Acid/pharmacology , Piperacillin/administration & dosage , Piperacillin/adverse effects , Piperacillin/pharmacology , Piperacillin, Tazobactam Drug Combination , beta-Lactams/administration & dosage , beta-Lactams/pharmacologySubject(s)
Dermatitis, Contact/etiology , Tattooing/adverse effects , Child , Humans , Male , Time FactorsABSTRACT
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