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1.
Aktuelle Urol ; 54(5): 405-413, 2023 09.
Article in German | MEDLINE | ID: mdl-37611602
2.
Aktuelle Urol ; 53(3): 279-288, 2022 06.
Article in German | MEDLINE | ID: mdl-35671971
3.
World J Urol ; 39(1): 11-25, 2021 Jan.
Article in English | MEDLINE | ID: mdl-31552467

ABSTRACT

PURPOSE: For patients with prostate cancer, validated and reliable instruments are essential for measuring patient-reported outcomes. The aim of this study was to validate the German version of the widely established Expanded Prostate Cancer Index Composite with 26 items (EPIC-26). METHODS: A German translation of the original questionnaire was tested in 3094 patients with localized or locally advanced (any T, any N and M0) prostate cancer with treatment intent (including radical prostatectomy, brachytherapy, active surveillance, watchful waiting). They completed the EPIC-26 questionnaire before treatment. A total of 521 of them also completed a questionnaire 12 months afterward. Internal consistency, sensitivity to change, and construct validity were assessed. RESULTS: The internal consistency of all domains was sufficient (Cronbach's alpha between 0.64 and 0.93). Item-to-scale correlation coefficients showed acceptable associations between items and their domain score (all > 0.30), with the lowest scores for "bloody stools" (r = 0.37) and "breast problems" (r = 0.32). Confirmatory and exploratory factor analysis confirmed the five-dimension structure of the EPIC-26 (comparative fit index 0.95). CONCLUSIONS: Psychometric evaluation suggests that the German version of the EPIC-26 is a well-constructed instrument for measuring patient-reported health-related symptoms in patients with prostate cancer.


Subject(s)
Patient Reported Outcome Measures , Prostatic Neoplasms/therapy , Psychometrics , Aged , Humans , Male , Middle Aged , Neoplasm Staging , Prostatic Neoplasms/pathology , Surveys and Questionnaires , Translations
4.
J Patient Rep Outcomes ; 4(1): 56, 2020 Jul 13.
Article in English | MEDLINE | ID: mdl-32661594

ABSTRACT

PURPOSE: To give an overview of the multicenter Prostate Cancer Outcomes (PCO) study, involving paper-based and web-based collection of patient-reported outcome measures (PROM) in patients undergoing local treatment for prostate cancer in certified centers in Germany. The PCO study is part of the larger Movember-funded TrueNTH Global Registry. The article reports on the study's design and provides a brief progress report after the first 2 years of data collection. METHODS: Prostate cancer centers (PCCs) certified according to German Cancer Society requirements were invited to participate in collecting patient-reported information on symptoms and function before and at least once (at 12 months) after treatment. The data were matched with disease and treatment information. This report describes progress in patient inclusion, response rate, and variations between centers relative to online/paper use, and also data quality, including recruitment variations relative to treatment in the first participating PCCs. RESULTS: PCC participation increased over time; 44 centers had transferred data for 3094 patients at the time of this report. Patient recruitment varied widely across centers. Recruitment was highest among patients undergoing radical prostatectomy. The completeness of the data was good, except for comorbidity information. CONCLUSIONS: The PCO study benefits from a quality improvement system first established over 10 years ago, requiring collection and harmonization of a predefined clinical dataset across centers. Nevertheless, establishing a PROM routine requires substantial effort on the part of providers and constant monitoring in order to achieve high-quality data. The findings reported here may be useful for guiding implementation in similar initiatives.

5.
Nat Ecol Evol ; 2(10): 1674, 2018 10.
Article in English | MEDLINE | ID: mdl-30120372

ABSTRACT

An earlier version of the Supplementary Information was mistakenly uploaded when this Perspective was published, and was live until 14 August 2018, when the correct version was uploaded.

6.
Nat Ecol Evol ; 2(9): 1352-1357, 2018 09.
Article in English | MEDLINE | ID: mdl-30104749

ABSTRACT

The release of classified documents in the past years have offered a rare glimpse into the opaque world of tax havens and their role in the global economy. Although the political, economic and social implications related to these financial secrecy jurisdictions are known, their role in supporting economic activities with potentially detrimental environmental consequences have until now been largely ignored. Here, we combine quantitative analysis with case descriptions to elaborate and quantify the connections between tax havens and the environment, both in global fisheries and the Brazilian Amazon. We show that while only 4% of all registered fishing vessels are currently flagged in a tax haven, 70% of the known vessels implicated in illegal, unreported and unregulated fishing are, or have been, flagged under a tax haven jurisdiction. We also find that between October 2000 and August 2011, 68% of all investigated foreign capital to nine focal companies in the soy and beef sectors in the Brazilian Amazon was transferred through one, or several, known tax havens. This represents as much as 90-100% of foreign capital for some companies investigated. We highlight key research challenges for the academic community that emerge from our findings and present a set of proposed actions for policy that would put tax havens on the global sustainability agenda.


Subject(s)
Agriculture , Conservation of Natural Resources , Taxes , Animals , Brazil
7.
BMC Cancer ; 17(1): 850, 2017 Dec 14.
Article in English | MEDLINE | ID: mdl-29241445

ABSTRACT

BACKGROUND: Over the last decades numerous initiatives have been set up that aim at translating the best available medical knowledge and treatment into clinical practice. The inherent complexity of the programs and discrepancies in the terminology used make it difficult to appreciate each of them distinctly and compare their specific strengths and weaknesses. To allow comparison and stimulate dialogue between different programs, we in this paper provide an overview of the German Cancer Society certification program for multidisciplinary cancer centers that was established in 2003. MAIN BODY: In the early 2000s the German Cancer Society assessed the available information on quality of cancer care in Germany and concluded that there was a definite need for a comprehensive, transparent and evidence-based system of quality assessment and control. This prompted the development and implementation of a voluntary cancer center certification program that was promoted by scientific societies, health-care providers, and patient advocacy groups and based on guidelines of the highest quality level (S3). The certification system structures the entire process of care from prevention to screening and multidisciplinary treatment of cancer and places multidisciplinary teams at the heart of this program. Within each network of providers, the quality of care is documented using tumor-specific quality indicators. The system started with breast cancer centers in 2003 and colorectal cancer centers in 2006. In 2017, certification systems are established for the majority of cancers. Here we describe the rationale behind the certification program, its history, the development of the certification requirements, the process of data collection, and the certification process as an example for the successful implementation of a voluntary but powerful system to ensure and improve quality of cancer care. CONCLUSION: Since 2003, over 1 million patients had their primary tumors treated in a certified center. There are now over 1200 sites for different tumor entities in four countries that have been certified in accordance with the program and transparently report their results from multidisciplinary treatment for a substantial proportion of cancers. This led to a fundamental change in the structure of cancer care in Germany and neighboring countries within one decade.


Subject(s)
Cancer Care Facilities/organization & administration , Neoplasms/therapy , Patient Care Team/organization & administration , Quality of Health Care/organization & administration , Societies, Medical/standards , Cancer Care Facilities/standards , Cancer Care Facilities/trends , Certification , Germany , Humans , Interdisciplinary Communication , Patient Care Team/trends , Practice Guidelines as Topic , Program Evaluation , Quality of Health Care/trends
8.
Sci Rep ; 7(1): 6246, 2017 07 24.
Article in English | MEDLINE | ID: mdl-28740120

ABSTRACT

Multinational corporations use highly complex structures of parents and subsidiaries to organize their operations and ownership. Offshore Financial Centers (OFCs) facilitate these structures through low taxation and lenient regulation, but are increasingly under scrutiny, for instance for enabling tax avoidance. Therefore, the identification of OFC jurisdictions has become a politicized and contested issue. We introduce a novel data-driven approach for identifying OFCs based on the global corporate ownership network, in which over 98 million firms (nodes) are connected through 71 million ownership relations. This granular firm-level network data uniquely allows identifying both sink-OFCs and conduit-OFCs. Sink-OFCs attract and retain foreign capital while conduit-OFCs are attractive intermediate destinations in the routing of international investments and enable the transfer of capital without taxation. We identify 24 sink-OFCs. In addition, a small set of five countries - the Netherlands, the United Kingdom, Ireland, Singapore and Switzerland - canalize the majority of corporate offshore investment as conduit-OFCs. Each conduit jurisdiction is specialized in a geographical area and there is significant specialization based on industrial sectors. Against the idea of OFCs as exotic small islands that cannot be regulated, we show that many sink and conduit-OFCs are highly developed countries.

9.
World J Urol ; 34(5): 665-72, 2016 May.
Article in English | MEDLINE | ID: mdl-26391484

ABSTRACT

PURPOSE: In 2008, the German Cancer Society certification program for prostate cancer centers (PCCs) was introduced, fostering multidisciplinary and interprofessional cooperation. Since then, 97 PCCs have been certified. This paper describes the PCC certification program, quality indicators (QI) that are reported during certification, as well as changes over time and correlates of QI fulfillment. METHODS: Observational data from 70,683 primary prostate cancer (PCa) cases treated between 2010 and 2013 in certified PCC sites are analyzed using descriptive and correlation analyses. RESULTS: Fulfillment of the requirements is high with over 80 % of the sites fulfilling the requirements for most of the presented QIs with defined target values. Fulfillment increased slightly over time, with significant improvements in conducting multidisciplinary tumor conferences (increasing proportion of cases presented pre- and post-treatment, increasing participation of specialists), psycho-oncologic care, social service counseling and research participation. Bivariate associations between hospital characteristics and QIs observed were most distinct for time since first certification. CONCLUSIONS: Results suggest that the PCC certification program presented contributes to establishing multidisciplinary teams over time and assures the provision of high-quality PCa care. However, differences in fulfillment of the requirements exist with regard to hospital characteristics beyond the scope of the certification system.


Subject(s)
Cancer Care Facilities/standards , Certification , Prostatic Neoplasms , Quality Indicators, Health Care , Germany , Humans , Male , Prostatic Neoplasms/therapy , Societies, Medical
11.
Urol Int ; 84(4): 461-6, 2010.
Article in English | MEDLINE | ID: mdl-20224266

ABSTRACT

The incidence of prostate cancer and the resultant mortality rates in Japanese men are lower compared with the rates for Caucasians; however, the Gleason score at diagnosis is higher in Japanese men compared with Caucasians. Loss of 13q is one of the most common chromosomal alterations in prostate cancer. To elucidate the difference in the rate of loss of 13q between Japanese and Caucasian men, we examined the allelic imbalance (AI) on chromosome 13q in 32 Japanese and 39 German prostate cancer patients with a fluorescent polymerase chain reaction technique using 12 microsatellite markers. Benign and malignant histology was identified by a single pathologist and laser capture microdissection was used to gather cancer cells. Although there were no statistical differences in patient background characteristics, the frequency of AI at 13q14 (D13S1253) and at 13q21 (D13S166) was significantly higher in Japanese patients compared with German patients (p = 0.0128 and p = 0.0078, respectively). The frequency of AI at 13q14 was significantly higher in tumors with high Gleason scores (GS) compared with tumors with low GS (p = 0.0478). The present observations suggest that the frequency of genetic alterations at 13q14 may underlie differences in the biological behavior of prostate cancer between Japanese and Caucasian populations.


Subject(s)
Adenocarcinoma/genetics , Asian People/genetics , Chromosomes, Human, Pair 13 , Prostatic Neoplasms/genetics , White People/genetics , Adenocarcinoma/ethnology , Adenocarcinoma/pathology , Aged , Allelic Imbalance , Chi-Square Distribution , Genotype , Germany/epidemiology , Humans , Japan/epidemiology , Loss of Heterozygosity , Male , Microsatellite Repeats , Middle Aged , Neoplasm Staging , Phenotype , Polymerase Chain Reaction , Prognosis , Prostatic Neoplasms/ethnology , Prostatic Neoplasms/pathology
12.
J Urol ; 172(5 Pt 1): 1970-2; discussion 1972, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15540768

ABSTRACT

PURPOSE: We review the long-term results of buccal mucosa onlay grafting for urethral reconstruction in hypospadias surgery in patients with followup of at least 5 years. MATERIALS AND METHODS: We retrospectively evaluated 132 patients who underwent buccal mucosa onlay graft for hypospadias repair, including 34 who underwent "salvage" grafting, during a 10-year period at our institution. In 49 cases with available followup longer than 5 years (average 6.2) complications were analyzed in detail. RESULTS: The overall complication rate was 24% (12 of 49 patients), with all but 3 complications occurring during the first postoperative year (3 fistulas, 1 stricture, 1 meatal stenosis, 2 graft contractures, 2 scars at oral harvesting site). The remaining 3 complications manifested during postoperative years 2 and 3, and encompassed 2 anastomotic strictures at the proximal anastomosis and 1 meatal stenosis. CONCLUSIONS: Buccal mucosa onlay grafts for urethral reconstruction in hypospadias repair seem to provide stable long-term results, with complications occurring primarily during the first 12 months postoperatively.


Subject(s)
Hypospadias/surgery , Mouth Mucosa/transplantation , Adolescent , Adult , Child , Child, Preschool , Follow-Up Studies , Humans , Male , Postoperative Complications/epidemiology , Retrospective Studies , Time Factors
13.
Urology ; 64(4): 648-50, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15491691

ABSTRACT

OBJECTIVES: To evaluate our patients who were treated with ventral buccal mucosa onlay grafts for open urethral stricture repair with a follow-up exceeding 5 years. Buccal mucosa onlay is widely used for urethral reconstruction; however, the long-term outcome of these patients remains unclear. METHODS: During the past 10 years, 67 patients underwent ventral buccal mucosa onlay graft surgery for urethral stricture repair. Of these, 32 were followed up for longer than 5 years (mean 6.9 years) for the occurrence and timing of any postoperative complications. All patients had undergone prior internal urethrotomy (mean 2.9 procedures), and the average length of the stricture was 4.3 cm (range 3 to 17). RESULTS: The overall complication rate was 25% (8 of 32). We observed one fistula, one graft infection/necrosis, two lower lip scars with transient impairment of lip motility, and four recurrent strictures (at the proximal anastomosis), all of which were treated successfully with internal urethrotomy. All but one recurrent stricture occurred during the first 12 postoperative months. CONCLUSIONS: Ventral buccal mucosa onlay grafting for urethral stricture repair provides stable long-term results with complications occurring primarily during the first 12 postoperative months.


Subject(s)
Mouth Mucosa/transplantation , Transplantation, Heterotopic , Urethral Stricture/surgery , Cicatrix/epidemiology , Cicatrix/etiology , Female , Follow-Up Studies , Humans , Male , Postoperative Complications/epidemiology , Recurrence , Retrospective Studies , Surgical Wound Infection/epidemiology , Surgical Wound Infection/etiology , Treatment Outcome , Urinary Fistula/epidemiology , Urinary Fistula/etiology
14.
BJU Int ; 94(6): 802-4, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15476512

ABSTRACT

OBJECTIVE: To evaluate the possibility of a perineal radical prostatectomy (PRP) under spinal anaesthesia, as although it is usually done under general anaesthesia, there is currently a need to minimize costs and morbidity. PATIENTS AND METHODS: Between January and December 2003, there were 337 PRPs at our institution, of which 47 were on patients under combined spinal/epidural (CSE) anaesthesia administered via a standard L3/4 or L4/5 approach. We analysed the feasibility of PRP under CSE and evaluated perioperative morbidity, including blood loss and hospital stay. RESULTS: All 47 procedures were done under CSE with no need for conversion to general anaesthesia. The mean (range) duration of PRP was 56 (43-112) min, the mean blood loss 270 mL, and the transurethral catheter was removed at 7 days in 40 and at 14 days in the remaining seven patients. There were no complications during surgery, e.g. rectal or ureteric lesions. The mean hospital stay was 8.2 days. CONCLUSION: PRP is safe under CSE anaesthesia; this may be helpful in minimizing morbidity and medical costs, as well as providing an alternative in patients in whom general anaesthesia is not recommended.


Subject(s)
Anesthesia, Spinal/methods , Prostatectomy/methods , Prostatic Neoplasms/surgery , Aged , Anesthesia, Epidural/methods , Blood Loss, Surgical , Feasibility Studies , Humans , Length of Stay , Male
15.
J Urol ; 172(1): 124-8, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15201751

ABSTRACT

PURPOSE: Although groups at several institutions have long experience with radical perineal prostatectomy (RPP), only few reports of larger series describe associated complications, mostly without reporting management options in detail. We analyzed specific perioperative and postoperative complications of the perineal approach and management strategies thereof. MATERIALS AND METHODS: The medical records of 630 patients who underwent RPP between January 1997 and May 2003 were retrospectively reviewed in regard to complications and their management. Median followup was 8 months (range 1 to 68). RESULTS: Major complications requiring open surgical intervention were noted in 11 patients (1.7%) for a total surgical revision rate of 2.4% (15 of 630). Two patients with persistent urinary fistula required fistula excision and closure. Two patients with a rectocutaneous fistula needed temporary diverting colostomy. Three patients with a combined urinary and fecal fistula were treated with protective colostomy, fistula excision and the interposition of a tunica vaginalis graft. No further morbidity was observed in these patients. In 7 patients a subvesical hematoma was drained surgically, including 3 mentioned in whom a hematoma expanded into the urethral anastomosis. Minor complications, which could be successfully managed conservatively or with endoscopic interventions only, developed in 124 patients for a total rate of 19.7%. In the long term 9% of the patients experienced postoperative de novo changes in stool habits after RPP but only 2.7% reported distressing anal sphincter incompetence. CONCLUSIONS: RPP is a safe and reproducible procedure with low major complication and reintervention rates even in a training center setting with many involved surgeons. A subvesical hematoma should be revised early since it can be the origin of subsequent major complications.


Subject(s)
Prostatectomy/adverse effects , Prostatic Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Anastomosis, Surgical , Hematoma/diagnostic imaging , Hematoma/etiology , Hematoma/surgery , Humans , Male , Middle Aged , Perineum , Retrospective Studies , Tomography, X-Ray Computed
16.
An. paul. med. cir ; 123(2): 41-4, abr.-jun. 1996. ilus
Article in Portuguese | LILACS | ID: lil-182947

ABSTRACT

Os autores discutem as opçöes para o tratamento cirúrgico da extrofia da bexiga, confrontando os procedimentos de reconstruçäo vesical com a derivaçäo urinária primária. Apresentam a seguir resumidamente a técnica operatória do pouch sigmóide-reto (Mainz Pouch II) e os resultados de 17 pacientes com extrofia de bexiga submetidos a esta cirurgia. Ausência de complicaçöes perioperatórias e índices de continência de 92,8 por cento foram obtidos como resultados


Subject(s)
Bladder Exstrophy/surgery , Surgical Procedures, Operative , Urinary Bladder/surgery , Urinary Diversion
17.
São Paulo; Atneneu; 1996. 411 p. ilus.
Monography in Portuguese | Coleciona SUS | ID: biblio-927091

Subject(s)
Male , Female , Humans , Urology
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