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Dalton Trans ; 41(13): 3720-5, 2012 Apr 07.
Article in English | MEDLINE | ID: mdl-22327273

ABSTRACT

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.


Subject(s)
Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Heterocyclic Compounds/chemistry , Methane/analogs & derivatives , Organometallic Compounds/chemistry , Organometallic Compounds/pharmacology , Silver/chemistry , Cell Line, Tumor , Humans , Ligands , Methane/chemistry
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