ABSTRACT
The incidence of bone disorders, whether due to trauma or pathology, has been trending upward with the aging of the worldwide population. The currently available treatments for bone injuries are rather limited, involving mainly bone grafts and implants. A particularly promising approach for bone regeneration uses rapid prototyping (RP) technologies to produce 3D scaffolds with highly controlled structure and orientation, based on computer-aided design models or medical data. Herein, tricalcium phosphate (TCP)/alginate scaffolds were produced using RP and subsequently their physicochemical, mechanical and biological properties were characterized. The results showed that 60/40 of TCP and alginate formulation was able to match the compression and present a similar Young modulus to that of trabecular bone while presenting an adequate biocompatibility. Moreover, the biomineralization ability, roughness and macro and microporosity of scaffolds allowed cell anchoring and proliferation at their surface, as well as cell migration to its interior, processes that are fundamental for osteointegration and bone regeneration.
Subject(s)
Bone Regeneration/physiology , Osteoblasts/physiology , Tissue Scaffolds , Biocompatible Materials/pharmacology , Calcium/metabolism , Cell Line , Humans , Microscopy, Electron, Scanning , Phosphorus/metabolism , Spectroscopy, Fourier Transform Infrared , Surface PropertiesABSTRACT
Foram estudados os niveis sericos de acido folico em 30 mulheres com displasia uterina ou carcinoma in situ. Nao foram evidenciadas diferencas estatisticamente significativas quando comparadas aos de mulheres normais
Subject(s)
Humans , Female , Folic Acid , Uterine Diseases , Uterine Neoplasms , Carcinoma in SituABSTRACT
Testosterona foi determinada em amostras de homens normospermicos, oligospermicos e azoospermicos. Foi observado um descrecimo significante em amostras de azoospermicos e oligospermicos. Uma correlacao positiva foi encontrada entre os niveis de testosterona e a motilidade dos espermatozoides
Subject(s)
Humans , Male , Semen , Testosterone , OligospermiaABSTRACT
Cyclic adenosine monophosphate normally stimulates motility of spermatozoa. Its concentration in cervical mucus was studied by an isotopic competitive method in 15 normal women aged between 20 and 50 years. Values were very high, particularly in the periovulatory period, with a mean (+/-SD) value of 167.90 +/- 154.96 nmol/l. These are very high when compared with values in other biological fluids (blood serum and urine).
