Cuffed versus uncuffed endotracheal tubes for general anaesthesia in children aged eight years and under.

BACKGROUND: Since the introduction of endotracheal intubation in paediatrics, uncuffed endotracheal tubes (ETTs) have been the standard of care for children under eight years old, based on the presumption that complications, particularly postoperative stridor, are higher with cuffed ETTs. The major disadvantages of uncuffed ETTs cited for this shift in procedure include the difficulty in achieving tidal volumes due to leakage around an uncuffed ETT. To seal the airway adequately, uncuffed tubes may need to be exchanged for another tube with a larger diameter, which sometimes requires several attempts before the appropriate size is found. Uncuffed tubes also allow waste anaesthetic gases to escape, contributing significantly to operating room contamination and rendering the anaesthetic procedure more expensive. Our review summarizes the available data, to provide a current perspective on the use of cuffed versus uncuffed endotracheal tubes in children of eight years old or less. OBJECTIVES: To assess the risks and benefits of cuffed versus uncuffed endotracheal tubes during general anaesthesia in children up to eight years old. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, CINAHL, LILACS and Google Scholar databases from their inception until March 2017. We also searched databases of ongoing trials, and checked references and citations. We imposed no restriction by language. SELECTION CRITERIA: We included randomized and quasi-randomized controlled trials in which the effects of using cuffed and uncuffed tubes were investigated in children up to eight years old undergoing general anaesthesia. We excluded studies conducted solely in newborn babies. DATA COLLECTION AND ANALYSIS: We applied standard methodological procedures, as defined in the Methodological Expectations of Cochrane Intervention Reviews (MECIR). MAIN RESULTS: We included three trials (2804 children), comparing cuffed with uncuffed ETTs. We rated the risks of bias in all three trials as high. Outcome data were limited. The largest trial was supported by Microcuff GmbH, who provided the cuffed tubes used. The other two trials were small, and should be interpreted with caution. Based on the GRADE approach, we rated the quality of evidence as low to very low.Two trials comparing cuffed versus uncuffed ETTs found no difference between the groups for postextubation stridor (risk ratio (RR) 0.93, 95% confidence interval (CI) 0.65 to 1.33; 2734 children; quality of evidence very low). However, those two trials demonstrated a statistically significantly lower rate of endotracheal tube exchange in the cuffed ETT group (RR 0.07, 95% CI 0.05 to 0.10; 2734 children; quality of evidence very low).One trial with 70 participants found that costs per case were lower in the cuffed ETT group (mean difference (MD) EUR 19.0 lower; 95% CI 24.23 to 13.77 lower; quality of evidence low), since the higher cost of the cuffed tubes may be offset by the savings made with anaesthetic gases.No clear evidence emerged to suggest any difference between cuffed and uncuffed tubes for outcomes such as the need to treat postextubation stridor with tracheal re-intubation (RR 1.85, 95% CI 0.17 to 19.76; 115 children; 2 trials; quality of evidence very low), epinephrine (RR 0.70, 95% CI 0.38 to 1.28; 115 children; 2 trials; quality of evidence very low) or corticosteroid (RR 0.87, 95% CI 0.51 to 1.49; 102 children; 1 trial; quality of evidence very low), or need for intensive care unit (ICU) admission to treat postextubation stridor (RR 2.77, 95% CI 0.30 to 25.78; 102 children; 1 trial; quality of evidence very low).None of the trials included in this review evaluated the ability to deliver appropriate tidal volume. AUTHORS' CONCLUSIONS: Implications for practiceWe are unable to draw definitive conclusions about the comparative effects of cuffed or non-cuffed endotracheal tubes in children undergoing general anaesthesia. Our confidence is limited by risks of bias, imprecision and indirectness. The lower requirement for exchange of tubes with cuffed ETTs was very low-quality evidence, and the requirement for less medical gas used and consequent lower cost was low-quality evidence. In some cases, tracheal re-intubation is required to guarantee an open airway when adequate oxygenation is difficult after removal of the tube, for a variety of reasons including stridor, muscle weakness or obstruction. No data were available to permit evaluation of whether appropriate tidal volumes were delivered. Implications for researchLarge randomized controlled trials of high methodological quality should be conducted to help clarify the risks and benefits of cuffed ETTs for children. Such trials should investigate the capacity to deliver appropriate tidal volume. Future trials should also address cost effectiveness and respiratory complications. Such studies should correlate the age of the child with the duration of intubation, and with possible complications. Studies should also be conducted in newborn babies. Future research should be conducted to compare the effects of the different types or brands of cuffed tubes used worldwide. Finally, trials should be designed to perform more accurate assessments and to diagnose the complications encountered with cuffed compared to uncuffed ETTs.

Correlation between pre-pregnancy body mass index and maternal visceral adiposity with fetal biometry during the second trimester.

OBJECTIVE: To determine the correlation between pre-pregnancy body mass index (BMI) and maternal visceral adiposity with fetal biometry during the second trimester. METHODS: A cross-sectional observational study was conducted among pregnant women who received prenatal care at a center in Recife, Brazil, between October 3, 2011, and September 27, 2013. Pre-pregnancy BMI was determined at the first prenatal care visit. Maternal visceral adiposity and fetal biometry were measured at the same ultrasonography session. The associations between maternal and fetal variables were evaluated using the Pearson correlation coefficient (R). The Student t test was used to test the null hypothesis of adjusted correlation coefficients. RESULTS: Overall, 740 women were included. No correlation was found between pre-pregnancy BMI and any of the fetal biometric variables assessed. By contrast, maternal visceral adiposity positively correlated with fetal abdominal circumference (R=0.529), estimated fetal weight (R=0.524), head circumference (R=0.521), femur length (R=0.521), and biparietal diameter (R=0.524; P<0.001 for all fetal variables). These findings remained statistically significant after controlling for pregnancy length. CONCLUSION: Maternal visceral adiposity, but not pre-pregnancy BMI, positively correlated with fetal biometry during the second trimester.

Maternal pelvic dimensions and neonatal size: Implications for growth plasticity in early life as adaptation.

Patterns of fetal growth predict non-communicable disease risk in adult life, but fetal growth variability appears to have a relatively weak association with maternal nutritional dynamics during pregnancy. This challenges the interpretation of fetal growth variability as 'adaptation'. We hypothesized that associations of maternal size and nutritional status with neonatal size are mediated by the dimensions of the maternal pelvis. We analysed data on maternal height, body mass index (BMI) and pelvic dimensions (conjugate, inter-spinous and inter-cristal diameters) and neonatal gestational age, weight, length, thorax girth and head girth (n = 224). Multiple regression analysis was used to identify independent maternal predictors of neonatal size, and the mediating role of neonatal head girth in these associations. Pelvic dimensions displaced maternal BMI as a predictor of birth weight, explaining 11.6% of the variance. Maternal conjugate and inter-spinous diameters predicted neonatal length, thorax girth and head girth, whereas inter-cristal diameter only predicted neonatal length. Associations of pelvic dimensions with birth length, but not birth weight, were mediated by neonatal head girth. Pelvic dimensions predicted neonatal size better than maternal BMI, and these associations were mostly independent of maternal height. Sensitivity of fetal growth to pelvic dimensions reduces the risk of cephalo-pelvic disproportion, potentially a strong selective pressure during secular trends in height. Selection on fetal adaptation to relatively inflexible components of maternal phenotype, rather than directly to external ecological conditions, may help explain high levels of growth plasticity during late fetal life and early infancy.

Longitudinal variance of visceral fat thickness in pregnant adolescents.

This study aims to investigate the longitudinal change in visceral fat thickness (VFT) during normal pregnancy. A prospective cohort study with 75 primiparous adolescents was carried out in Petrolina, Brazil. VFT was evaluated by ultrasound between 12-20 weeks gestation and immediately after delivery. We noted a statistically significant increase in VFT; 1.3 cm ± 1.0. No correlation was found between VFT and maternal anthropometric variables. VFT increases about 30% from the first to the second half of pregnancy in primiparous adolescents.

Smaller pelvic size in pregnant adolescents contributes to lower birth weight.

Adolescent pregnancy is associated with low birth weight. This has been explained by socioeconomic or emotional factors. However, an adolescent's pelvis may not be completely developed and this can contribute to impairing fetal growth. Our aim was to compare the relationship between pelvic size and birth weight among adolescents and adult mothers. A cross-sectional study was carried out at Instituto de Medicina Infantil Professor Fernando Figueira (IMIP), Brazil. We studied 125 healthy adolescents and 207 healthy adult women, all of whom were primiparous with a singleton term and low-risk pregnancy. The conjugate, intercristal and interspinous diameters were assessed by the Collins pelvimeter. The effect of pelvic size on the birth weight was evaluated using principal component analysis and multiple linear regression model. The mean pelvic size was smaller in adolescent mothers compared to adult ones (35.1 cm vs. 37.5 cm; p<0.001; t-test). After adjusting for other confounding variables, the predicted birth weights corresponding to these mean values of pelvic size were: 3020±27 g for adolescent mothers and 3145±26 g for adult mothers and showed a significant difference (p<0.001). We concluded that a pelvis that is less than fully developed in adolescents, as assessed by pelvic size, may contribute to lower birth weight in adolescent mothers.

Resultado de pesquisa sobre a frequência de aleitamento materno exclusivo varia de acordo com a forma de abordagem na entrevista / Results of research into the frequency of exclusive breastfeeding vary depending on the approach taken in the interview

OBJETIVO: Comparar a frequência do aleitamento materno exclusivo segundo duas metodologias de abordagem na entrevista. MÉTODOS: Estudo transversal em amostra de 309 mães de crianças de 0 a 6 meses, com idade mediana de 11 dias, atendidas no Instituto de Medicina Integral Prof. Fernando Figueira entre novembro e dezembro de 2009. Foram testadas duas abordagens na entrevista: na primeira, questionou-se se a mãe ofereceu outros alimentos nas 24 horas anteriores à entrevista; em seguida, se em algum momento da vida da criança foram oferecidos outros alimentos. Utilizou-se o teste de homogeneidade marginal, adotando nível de significância de 5 por cento. RESULTADOS: De acordo com o recordatório de 24 horas, a frequência do aleitamento materno exclusivo correspondeu a 78,0 por cento. Em relação ao recordatório mais abrangente, foi de 59,2 por cento (p < 0,001). CONCLUSÕES: A frequência do aleitamento materno exclusivo é superestimada no recordatório de 24 horas, quando comparada à obtida com recordatório mais abrangente.

OBJECTIVE: To compare the frequency of exclusive breastfeeding using two different interview approaches. METHODS: This was a cross-sectional study of 309 mothers of children aged 0 to 6 months, with a median age of 11 days. Mothers were interviewed at the Instituto de Medicina Integral Prof. Fernando Figueira during November and December of 2009. Two approaches to the interview were tested: firstly, the mother was asked if complementary foods had been given during the preceding 24 hours. Secondly, they were asked if at any point during the child’s life any other foods had been given. The marginal homogeneity test was applied and the significance level was 5 percent. RESULTS: According to the 24-hour recall, the frequency of exclusive breastfeeding was 78.0 percent. According to the wider-ranging recall period, the frequency was 59.2 percent (p < 0.001). CONCLUSIONS: The frequency of the exclusive breastfeeding is overestimated using the 24-hour recall compared with the whole-life recall.

Results of research into the frequency of exclusive breastfeeding vary depending on the approach taken in the interview.

OBJECTIVE: To compare the frequency of exclusive breastfeeding using two different interview approaches. METHODS: This was a cross-sectional study of 309 mothers of children aged 0 to 6 months, with a median age of 11 days. Mothers were interviewed at the Instituto de Medicina Integral Prof. Fernando Figueira during November and December of 2009. Two approaches to the interview were tested: firstly, the mother was asked if complementary foods had been given during the preceding 24 hours. Secondly, they were asked if at any point during the child's life any other foods had been given. The marginal homogeneity test was applied and the significance level was 5%. RESULTS: According to the 24-hour recall, the frequency of exclusive breastfeeding was 78.0%. According to the wider-ranging recall period, the frequency was 59.2% (p < 0.001). CONCLUSIONS: The frequency of the exclusive breastfeeding is overestimated using the 24-hour recall compared with the whole-life recall.

Predictors of long-term anti-retroviral therapy effectiveness among Brazilian HIV-1-infected children in a hybrid scenario: what really matters?

The study objective was to evaluate the effectiveness and durability of highly active anti-retroviral therapy (HAART) in perinatally HIV-1-infected children and adolescents and its predictors. A historical cohort study was done at IMIP's Hospital in Recife, Brazil. The study included 195 subjects, 102 (52.3%) had successful response to HAART with a mean time of any HAART use of 4.9 [standard deviation (SD) 2.5; min. 0.7, max. 9.9] years. The time to failure of first HAART was negatively associated with male sex [relative hazard (RH) = 0.5, p = 0.021) and living out of metropolitan area (RH = 0.4, p = 0.009), and associated with Centres for Diseases Control and Prevention (CDC) immunological Stage 1 (RH = 2.9, p = 0.003) and patients who were adherent (RH = 2.2, p = 0.003). HAART success rate and mean time durability was similar to developed country data. However, the main predictors of success were: female sex, living in a metropolitan area, CDC1 immunological category and adherence.