[Changes in the indices of carbohydrate metabolism, of the lipoprotein spectrum and of the blood coagulation system in men with ischemic heart disease undergoing long-term propranolol treatment]. / Izmenenie nekotorykh pokazatelei uglevodnogo obmena, spektra lipoproteidov i sistemy svertyvaniia krovi u muzhchin s ishemicheskoi bolezn'iu serdtsa pri dlitel'nom lechenii propranololom.

The paper is concerned with evidence of the time course of blood sugar, lipoprotein spectrum and some values of the blood coagulation system in patients with CHD on prolonged propranolol therapy in comparison with their natural time course in a similar group of patients with CHD receiving no therapy. Propranolol therapy for 2 yrs. produced no changes in the lipoprotein spectrum and blood fibrinogen. The level of blood sugar on an empty stomach rose 6 and 12 mos after treatment and did not differ from the control one in 24 mos, and the coagulation index significantly exceeded the control one in 24 mos. The results obtained are suggestive of a necessity of control over the level of blood sugar and hemocoagulation during a prolonged and continuous intake of propranolol.

[The renin-aldosterone profile in hypertension]. / Renin-al'dosteronovyi profil' pri gipertonicheskoi bolezni.

Simultaneous study of renin activity and aldosterone concentration in the blood plasma of 180 out-patients with hypertensive disease has shown that persons with normal or increased reninemia predominate in the I stage of disease. Moderate positive correlation was observed between the level of aldosterone and renin activity; aldosterone-renin index at the stage of the disease remains unchanged. In stage II of hypertensive disease renin activity diminishes and the concentration of aldosterone in blood plasma rises, aldosteronerenin index is enhanced at the expense of aldosterone predominance, which is most often seen in the sub-group of patients with low reninemia. Aldosterone-renin index correlates positively with the duration of hypertensive disease.