ABSTRACT
The method of magnetic neutron capture therapy (MNTC) of cancer can be described as a combination of two methods: the targeted delivery of drugs using magnetic carriers and the proper neutron capture therapy which consists in tumor irradiation with thermal neutrons following the delivery of 10B compounds to the tumor site. Two-component ultradispersed particles containing Fe and C were tested as magnetic adsorbents of boron phenylalanine and borax. The quantities of absorbed borax proved sufficient for high concentration of boron atoms at the tumor site. The kinetics of boron release to saline substantiates the application of Fe-B (10%) ultradispersed particles for efficient MNTC. Both particle types have high magnetization and magnetic homogeneity, can form stable magnetic suspensions, and have low toxicity.
Subject(s)
Boron Compounds/toxicity , Boron Neutron Capture Therapy , Nanostructures/toxicity , Neoplasms/radiotherapy , Neutrons/therapeutic use , Animals , Boron Compounds/chemical synthesis , Boron Neutron Capture Therapy/adverse effects , Boron Neutron Capture Therapy/methods , Humans , Male , Mice , Mice, Inbred BALB C , Nanostructures/chemistry , Neoplasms/pathologyABSTRACT
A highly dispersed ferromagnetic powder obtained by a plasmochemical method (particle size was 100-500 A) was treated by means of an ultrasonic disperser: suspension was added to the trisodium phosphate homogenized and neutralized sputum (0.3 mg of the initial powder per 1 ml of sputum) of patients with various forms of pulmonary tuberculosis. The sputum was then incubated at slight stirring for 40 min and centrifuged; the precipitate was used to prepare smears which were stained with auramine; mycobacteria were detected by luminescence microscopy. The ferromagnetic suspension was found to increase luminescence microscopy sensitivity to 85.4%. The efficacy of the method was 30.8% more than that in the cultivation of infectious material in solid nutrient media.
Subject(s)
Mycobacterium tuberculosis/isolation & purification , Sputum/microbiology , Tuberculosis, Pulmonary/microbiology , Humans , Iron , Microscopy, Fluorescence/methods , PowdersABSTRACT
It has been demonstrated in cats that magnet-susceptible microspheres and liposomes containing neuromuscular blocking agents (dipyronium, pyrocurinum and diadonium) caused a deeper inhibition of the neuromuscular transmission in the limb placed in the magnetic field than in the control limb located beyond the field. The microparticles containing a short-acting neuromuscular blocking agent diadonium appeared to have the highest selectivity of action. The present method allows a pronounced neuromuscular block in a target area to be achieved without noticeable effect on PCO2 of the exhaled air.
Subject(s)
Drug Carriers , Microspheres , Animals , Cats , Electrolytes , Liposomes , Magnetics , Neuromuscular Blocking Agents/administration & dosageABSTRACT
The effect of tubocurarine enclosed in phosphatidylcholine and cholesterol liposomes on EEG of cats and rats was studied. Five to 15 minutes after its intravenous administration EEGs showed polyspike complexes as well as "peak-wave" complexes. Similar EEG changes were recorded on intracerebroventricular injection of tubocurarine solution. The absence of EEG changes after the injection is related to its poor permeability through the blood-brain barrier. The results obtained suggest that encapsulation of tubocurarine into liposomes facilitates its penetration through the blood-brain barrier.
Subject(s)
Brain/drug effects , Electroencephalography , Tubocurarine/pharmacology , Animals , Blood-Brain Barrier/drug effects , Brain/physiology , Cats , Drug Carriers , Injections, Intravenous , Injections, Intraventricular , Liposomes , Male , Seizures/chemically induced , Seizures/physiopathology , Tubocurarine/administration & dosageABSTRACT
The experiments on cats have shown that liposomes containing ferrocolloid and neuromuscular blocking agents (diadonium or dipyronium) cause selective muscle relaxation in the animal limb placed into the magnetic field, compared to the control limb kept outside the field. This effect was not related to the action of the magnetic field per se on neuromuscular transmission or the potency of neuromuscular blocking agents not contained in liposomes, but was induced by the accumulation of magnet-controlled liposomes in the target limb. The use of magnet-controlled liposomes for diadonium and dipyronium transport to one of the animal limbs decreases their unfavourable effect on respiratory muscle function.
