[Successful treatment for cryptococcal meningoencephalitis complicated by cerebral salt-wasting syndrome in a patient with chronic lymphocytic leukemia: A clinical case].

Cryptococcus neoformans is a common agent of fungal meningoencephalitis in immunocompromised patients. Cerebral salt-wasting syndrome is one of the rare causes of severe hyponatremia in patients with CNS diseases. The paper describes the first clinical case of a patient, whose onset of chronic lymphocytic leukemia was complicated by cryptococcal meningoencephalitis presenting with mental disorders and severe electrolytic imbalance. Antifungal treatment with amphotericin B and fluconazole could alleviate an infectious process and metabolic disturbances.

[The assessment of the interferon status of term newborns born to mothers with chronic nonspecific lung diseases]. / Otsenka sostoianiia interferonovogo statusa u donoshennykh novorozhdennykh, rodivshikhsia u materei s khronicheskimi nespetsificheskimi zabolevaniiami legkikh.

The study involved 34 full-term newborn babies born by mothers with chronic nonspecific diseases of the lungs and 10 newborns born by mothers with the physiological course of pregnancy and parturition, the examinations being carried out in the early neonatal period. A lower capacity for production of endogenous and gamma-interferons at delivery and on day 6 of life as well as a higher incidence of intrauterine and postnatal infections were observed in the newborns of the first group. This indicated the necessity to consider such babies as a group at risk of developing neonatal complications. The data of the study may be used for early diagnosis and prognosis of perinatal infections.

[Microbiological research on the secretion of the normal parotid glands and in acute and chronic non-mumps parotitis in children]. / Mikrobiologicheskie issledovaniia sekreta okoloushnykh sliunnykh zhelez v norme, pri ostrom i khronicheskom neépidemicheskom parotite u detei.

The qualitative and quantitative compositions of the microbial flora of the parotid gland were investigated in 42 children with nonepidemic parotiditis. The pathogenic properties of the microbial flora were the most pronounced in acute purulent and purulent necrotic parotiditis as compared to those in aggravation and remission of chronic parotiditis. In children with acute or chronic recurring parotiditis during its aggravation there was observed a significant increase in the number of the coccal organisms in the mixture of saliva and secretion of the parotid gland. Direct relationship between the aggravation activity and the number of the microbes was noted which testified to lowering of the protective functions of the oral cavity tissues. With an account of the presence of microorganisms in the clinically intact salivary glands it was concluded that the microbial factor was secondary in etiology of parotiditis. Quantitative estimation of bacteria in the mixture of saliva and parotid gland secretion is important for antibacterial therapy of the disease which is advisable when 1 ml of secretion of the affected glands contains 10(5) microorganisms. Their antibiotic sensitivity tests are obligatory.