ABSTRACT
It was shown that a single injection of heparin (250 units/kg) 15 min and 24 h before irradiation potentiated a slight radioprotective effect of cystamine (dichlorohydrate, 170 mg/kg) which was registered after the administration thereof to mice 30 min before irradiation with an absolutely lethal dose at a dose rate of 0.0025 Gy/c.
Subject(s)
Cystamine/therapeutic use , Heparin/therapeutic use , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , Animals , Drug Synergism , Male , MiceABSTRACT
A single administration of dextransulfate (40 mg/kg, 1-3 days before irradiation), or a double injection of heparin (250 units/kg, 24 hr and 15 min before irradiation) potentiated a weak radioprotective effect of gas hypoxic mixture (GHM-10) on animals exposed to absolutely lethal doses.
Subject(s)
Dextrans/administration & dosage , Heparin/administration & dosage , Nitrogen/administration & dosage , Oxygen/administration & dosage , Radiation-Protective Agents/administration & dosage , Animals , Dextran Sulfate , Drug Evaluation, Preclinical , Drug Synergism , Drug Therapy, Combination , Gamma Rays , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/prevention & controlABSTRACT
It has been shown that a single intraperitoneal injection of dextran sulfate (molecular weight 500 000, 60 mg/kg) to (CBA X C57BL)F1 mice 1-3 days before irradiation in lethal doses, with the irradiation dosage amounting to 8.10(-3), 3.10(-3) and 8.10(-4) Gy/c, increases the animals' survival rate. The effect of dextran sulfate on the degree of postradiation changes in the blood leukocyte count and in the bone marrow karyocyte count depends on the interval between dextran sulfate injection and irradiation.