ABSTRACT
Radiotherapeutic efficacious of the compounds from major organs and tissues of Central Asian tortoise--the animal known for its unique radioresistance, has been checked up. Along with the so well-known compounds as the plasma ones, tortoise spleen extracts (TSE) and the ones from the liver of adult animals and embryos, extracts from kidneys and muscles have been shown to increase the survivability rate of irradiated rats and mice. The compound, that called "Tortezin" shows the highest blood cell cytosol effect. The specific activity and the output are 4 and 12 times higher, than the ones of TSE, respectively. Dose increase factor (DIF) reaches as far as 1.41. The compound possesses considerable immunostimulating activity. The detailed physico-chemical characteristics of the compound, quite sufficient for its identification has been made.
Subject(s)
Adjuvants, Immunologic , Hematinics , Radiation Injuries, Experimental/drug therapy , Radiation-Protective Agents , Tissue Extracts , Turtles , Adjuvants, Immunologic/therapeutic use , Animals , Blood Cells/metabolism , Bone Marrow Cells/metabolism , Bone Marrow Cells/radiation effects , Cytosol/metabolism , Female , Hematinics/therapeutic use , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Tolerance , Radiation-Protective Agents/therapeutic use , Rats , Rats, Wistar , Thymidine/metabolism , Tissue Extracts/therapeutic use , Turtles/blood , Turtles/physiologyABSTRACT
In the experiments with white rats it was found, that the inhalation of freon 114B2 at CL16, CL50, CL84 levels caused the changes in seasonal values of the energy activity in mitochondria. The action of the freon 114B2 caused disturbances in regulation of the mitochondria activity and desynchronization of seasonal rhythms of their energy activity.