[Risk factors for obstructive sleep apnea in socio-demographic groups of the population of Chuvashia]. / Faktory riska sindroma obstruktivnogo apnoe sna v sotsial'no-demograficheskikh gruppakh naseleniya Chuvashii.

OBJECTIVE: To study risk factors (RF) of obstructive sleep apnea syndrome (OSAS) in the socio-demographic groups of the population of Chuvashia. MATERIALS AND METHODS: An anonymous survey included 2161 residents of Chuvashia (1007 men, 1154 women), aged from 18 to 70 years, average 36.5±13.8 years). Of all included people, 1547 (71.6%) lived in urban settlements, 614 (28.4%) in rural settlements. Exclusion criteria were those under the age of 18 and over 70. Body mass index (BMI) of more than 35 kg/m2, neck circumference of more than 43 cm for men or more than 37 cm for women, snoring, fatigue/drowsiness during the day, respiratory arrest in sleep and high blood pressure (BP) were considered as SOAS RF. The likelihood of OSAS was determined by the Lausanne NoSAS (Neck circumference, Obesity, Snoring, Age, Sex) test. RESULTS: RF OSAS were present in 63.4% of respondents. 2.4% of respondents had a BMI of more than 35 kg/m2, 162% had a large neck circumference. Snoring was detected in 24.4%, fatigue/drowsiness during the day in 42.2%, respiratory arrest in sleep in 8.1%, increased BP in 19.7%. In men, compared with women, the number of respondents with a high BMI, snoring, and respiratory failure in a dream was significantly larger; women with a large neck size and complaints of fatigue/drowsiness prevailed. The rural residents had more RF OSAS, including higher BMI, large neck circumference and snoring. The probability of OSAS according to the NoSAS score was 13.65%, including 21.35% of men and 6.93% of women, 11.38% of urban- and 19.38% of rural residents. Multivariate regression analysis showed that the OSAS prediction model included gender, age, BMI, the RF sum of four questions from the questionnaire, neck circumference and level of education with a probability of 99.99%. CONCLUSION: RF OSAS are widespread in the population of Chuvashia, which requires intensification of preventive measures to minimize them and the development of somnological service in the Republic.

[Sleep disorders as one of the indicators of postpartum depression]. / Rasstroistva sna kak odin iz pokazatelei poslerodovoi depressii.

Postpartum depression in ICD-10 refers to mild mental and behavioral disorders associated with physiological disorders of the postpartum period F53.0. Diagnosis is based on criteria, one of which is sleep disorders. The objective of the review is to characterize the postpartum sleep disorders and to reflect their predictor value in the development of postpartum depression. Presomnic, intrasomnic and postsomnic disorders with negative consequences for both the mother and her child were found in sleep disorders of women with postpartum depression. Depression with sleep disorders significantly affect the quality of life of the mother and infant. Sleep disorders are one of the predictors of postpartum depression. Improving of sleep quality is an effective way to prevent the effects of postpartum depression.

[Sensitivity and specificity of the cerebral blood flow reactions to acupuncture in the newborn infants presenting with hypoxic ischemic encephalopathy].

OBJECTIVE: To evaluate the effects of acupuncture integrated into the standard therapy, the condition of cerebral blood flow, and other syndromes associated with cerebral ischemia in the newborn infants. MATERIAL AND METHODS. A total of 131 pairs of puerperae and newborns with hypoxic ischemic encephalopathy were divided into four treatment groups. 34 children of the first group were given standard therapy (control), in the second group comprised of 33 mothers and children the standard treatment was supplemented by acupuncture, the third group included only 32 mothers given the acupuncture treatment alone, and the fourth group contained only 32 newborn infants treated by acupuncture. Each course of acupuncture treatment consisted of five sessions. Sensitivity and specificity of cerebral blood flow reactions were determined based on the results of the ROC-analysis and the area under the curve before and after the treatment. RESULTS: The treatment with the use of acupuncture greatly improved the cerebrospinal hemodynamics (p < 0.05). Other symptoms, viz. sleep disorders, vegetative reactivity and excitability were significantly reduced. The ROC analysis confirmed the effectiveness of acupuncture as a tool for the treatment of the impaired cerebral blood flow in the newborn babies. The high level of sensitivity (84.4-94.8%) associated with good specificity makes it possible to distinguish between the true positive and true negative cases. CONCLUSION: Acupuncture integrated into the treatment of "mother-baby" pairs presenting with hypoxic ischemic encephalopathy can be used to improve the initially low level of cerebral blood flow in neonates presenting with this condition.

[Prognostication of immunological reactivity and the choice of the variant of reflexotherapy for a newborn infant].

AIM: The objective of the present study was to determine the classification differences in immunological reactivity and to identify its predictors in the newborn infants. MATERIAL AND METHODS: The study involved 115 full-term newborn infants presenting with grade 3 prenatal hypoxic ischemic encephalopathy in the late neonatal period. The features of immunological reactivity under the influence of acupuncture were examined. Statistical processing was carried out by means of discriminant analysis. RESULTS: The assessment and prediction of the effectiveness of acupuncture in the neonates suffering from cerebral ischemia are based on the index of immunological reactivity and the leukocyte index of intoxication, as well as on the ratio of monocytes to band neutrophils content. For generation of the group classifier of immunological predictors in a newborn infant and development of indications for reflex therapy, nine parameters of interest were measured. The group specificity of the child was determined by three variables, viz. leukocyte index of intoxication, monocyte and band neutrophil counts with values of the Fisher's exact test (F) and reliability (Wilks Lambda 0.90894; approximation F (3.144) = 4.809; p < 0.0032). The partial Wilks Lambda values showed that the greatest contribution was provided by the leukocyte index of intoxication and monocytes. Prediction accuracy of the classification matrix in the standard treatment group reached 30.8% and 91.7% respectively when reflex therapy was included in the combined rehabilitation treatment. Overall, classification accuracy amounted to 70.3%. The presence of distinctive changes in the subgroups preconditioned a personalized approach to the prescription of reflex therapy to the newborn infants and the choice of the treatment modality on an individual basis (parent, child, or both) in the "mother-newborn" system. The variant of treatment was determined by comparing the values of the results of the formulas. The newborns were referred to the subgroup with the highest value of the classification function. The predictors made it possible to reliably distinguished the second (p = 0.032) and the third (p = 0.022) subgroups from the first one, with some degree of overlapping between the edge zones of centroids of the second and third subgroups (p = 0.073). Therefore, the sensitivity of classification in the individual subgroups was lower than in the group model and was estimated at 34.4, 71.9, and 65.6% for the first, second and third groups, respectively. CONCLUSION: The mathematical models can discriminatebetween the immunological characteristics and predict them in individual newborn infants; also, they can be helpful for preventing the disruption of their adaptation process.

[The role of phototherapy in the rehabilitation of newborn babies and infants].

This review is devoted to the problems pertaining to the rational application of phototherapy in the rehabilitation of newborn babies and infants. The analysis of the classical and present-day literature sources provided materials for the development of the rationale for the use of colour-puncture therapy. The data included in this review indicate that phototherapy has positive effect on the immune and rehabilitative processes in the newborns following surgical interventions and in the breast-fed infants suffering hypoxic ischemic encephalopathy. Phototherapy is equally beneficial when the newborn babies need to be treated for cutaneous and nervous disorders or undergo a surgical operation. Moreover, it can be applied to manage endocrine disorders and diseases of the vegetative nervous system. The photo-induced changes in the skin influence the concentration of biologically active compounds in the systemic circulation. It is believed that colour-puncture therapy makes it possible to selectively affect biologically active points in the channel-meridian system of the newborn babies and infants.

[The use of the contact periodic-pulse laser and microwave scalpels in liver surgery]. / Primenenie kontaktnogo impul'sno-periodicheskogo lazernogo i mikrovolnovogo skal'pelei v khirurgii pecheni.

In use of the laser (CPPLS) and microwave (MWS) scalpels, the reliability of arrest of bleeding and bile leakage has been proved not only at studies on the intact liver but on the models of jaundice with impaired coagulative blood properties as well. After hepatic resection by means of CPPLS and MWS, the impairement in its functional state lasts for a short time. In use of CPPLS, disturbance in tissue blood flow is less than in use of MWS. Healing of the wounds inflicted by CPPLS and MWS occurs in absence of pronounced exudative and inflammatory reactions. In a wound inflicted by a laser scalpel, the necrotic layer is not pronounced. It is expedient to use the CPPLS and MWS in patients with hepatic masses in technically difficult cholecystectomy as they contribute to decrease in intraoperative blood loss and prevention of the development of complications after the operation.

[Use of thermo-acoustic contact laser scalpel in surgery of the liver (an experimental study)]. / Primenenie termoakusticheskogo kontaktnogo lazernogo skal'pelia v khirurgii pecheni (Eksperimental'noe issledovanie).

Various parameters (from 15 to 40 W) of the thermo-acoustic contact YAG: Nd-laser scalpel were tested in experiments on 70 rabbits to choose the optimal operating regimens in resection of the liver. A power of 25-30 W proved to be effective. The reliability of hemo- and cholestasis was studied by means of hydro-pressure, reparation processes were studied by histological, electron microscopic, and radioautographic examination in periods of 3 hours to 30 days. The results of the study bear evidence that the use of the thermo-acoustic contact solid-body laser scalpel makes it possible to increase the rate of cutting with minimal injury to the peripheral areas of the hepatic tissue, significantly increases the reliability of hemostasis, produces fine homogeneous coagulation for the whole length, and facilitates a favourable course of the reparative processes. Besides, the contact method of laser division is controllable with regard to the depth of the beam effect and increases the surgeon's tactile sense.

[Hygienic regulation of static electric field generated by devices with electron-ray tube]. / Gigienicheskaia reglamentatsiia staticheskogo élektricheskogo polia, sozdavaemogo priborami s élektronno-luchevoi trubkoi.

When detecting and hygienically assessing the static electric field generated by the devices with a half-tone storage tube it is necessary to take account of the impact of a number of characteristics of field intensity ranging on the obtained results. Taking into consideration the above characteristics during the research permits to lower error in the derived values and approximate them to the characteristics affecting the organisms of those using devices with a half-tone storage tube.

[The effect of carnosine on indicators of free radical lipid oxidation during acute stress in rats]. / Vliianie karnozina na pokazateli svobodnoradikal'nogo okisleniia lipidov pri ostrom stresse u krys.

The effect of carnosine intraperitoneal injection in rats (in doses 0.2, 2.0 or 20 mg/kg) on the vegetative parameters (arterial blood pressure, Hildebrandt index), the content of free radical oxidation (FRO) products and superoxide dismutase activity in serum and brain homogenates and brain lipid composition under normal condition and after different stress forms have been investigated. The carnosine injection in dose 20 mg/kg preserves and increase in arterial pressure and Hildebrandt index at all steps of stress development. The phase non-unidirectional changes in studied biochemical parameters have been revealed depending on the level of stress development in animals under control. The unidirectional and dose-dependent changes of phospholipid content and the level of brain lipids, decrease of FRO products in tissue and brain cholesterol, the increase of the superoxide dismutase activity of serum and brain homogenates have been found in intact and stressed animals after carnosine injection. A comparison of carnosine pharmacokinetics with concentration dependences of the antioxidative effect under in vitro and in vivo experiments comes to conclusion concerning the carnosine indirect adaptogenic action.

Distribution of HB antigen carriers in the population of Budapest according to age, sex, subtypes and occupation.

The authors investigated serum samples of 5000 inhabitants (age 0 to 85 years) in a crowded industrial area, by means of the counterimmunoelectrophoretic method. They evaluate their results in relation of age, sex and occupation and presented literary data about the subtypes of the carriers in Budapest. They compared them with data of Hungarian and several other authors respectively. Some possible reasons of the differences are discussed and the importance of the non-parental transmission is emphasized.

Distribution of HB antigen carriers in the population of Budapest aged 0 to 85 years.

The authors investigated serum samples of 5,000 inhabitants aged 0-85 years in a crowded industrial area, by means of the counterimmunoelectrophoretic method. They evaluate their results in relation to age, sex and occupation. They compare them with data of Hungarian and several other authors. Some possible reasons of the differences are discussed and the importance of non-parenteral transmission is emphasized.