1.
Acta Paediatr
; 83(1): 84-7, 1994 Jan.
Article
in English
| MEDLINE
| ID: mdl-8193480
ABSTRACT
A two-year-old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications.
Subject(s)
Blood Coagulation Disorders/etiology , Factor V/antagonists & inhibitors , Fibrin Tissue Adhesive/adverse effects , Heart Septal Defects, Ventricular/surgery , Postoperative Complications , Anastomosis, Surgical/methods , Animals , Cattle , Child, Preschool , Humans , Male , Pulmonary Artery/surgery , Subclavian Artery/surgery
2.
Wien Klin Wochenschr
; 104(4): 101-4, 1992.
Article
in German
| MEDLINE
| ID: mdl-1570710
Subject(s)
Blood Coagulation Tests , Fibrin Tissue Adhesive/administration & dosage , Heart Defects, Congenital/surgery , Heart Ventricles/abnormalities , Pulmonary Artery/abnormalities , Thrombin/antagonists & inhibitors , Child , Female , Fibrin Tissue Adhesive/adverse effects , Fibrinogen/metabolism , Follow-Up Studies , Heart Defects, Congenital/blood , Heart Ventricles/surgery , Humans , Pulmonary Artery/surgery , Thrombin/metabolism
3.
Phys Med Biol
; 30(2): 175-6, 1985 Feb.
Article
in English
| MEDLINE
| ID: mdl-3920685
4.
Phys Med Biol
; 26(4): 711-4, 1981 Jul.
Article
in English
| MEDLINE
| ID: mdl-6789345