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1.
Paediatr Respir Rev ; 35: 15-19, 2020 Sep.
Article in English | MEDLINE | ID: mdl-32600820

ABSTRACT

Since January 2020, there has been a worldwide pandemic of COVID-19, caused by a novel coronavirus-severe acute respiratory syndrome coronavirus 2. The United States has been particularly affected, with the largest number of confirmed cases in a single country in the world. Healthcare systems for adults as well as children have dealt with challenges. This article will reflect on the experiences of selected children's hospitals in Seattle, New York City, and New Orleans, three of the "hotspots" in the US and share common aspects and lessons learned from these experiences. This article discusses testing and cohorting of patients, personal protective equipment utilization, limiting workplace exposure, and information sharing.


Subject(s)
Coronavirus Infections/epidemiology , Hospitals, Pediatric , Information Dissemination , Patient Isolation , Personal Protective Equipment , Pneumonia, Viral/epidemiology , Betacoronavirus , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Coronavirus Infections/prevention & control , Coronavirus Infections/therapy , Hospitals, Urban , Humans , New Orleans , New York City , Pandemics/prevention & control , Pneumonia, Viral/diagnosis , Pneumonia, Viral/prevention & control , Pneumonia, Viral/therapy , SARS-CoV-2 , United States
2.
Fetal Pediatr Pathol ; 39(3): 263-268, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32401577

ABSTRACT

Background: Cardiac damage is frequently referred to in patients with SARS-CoV-2, is usually diagnosed by enzyme elevations, and is generally thought to be due to underlying coronary artery disease. There are references to cardiomyopathies accompanying coronavirus, but there has been no histologic confirmation.Case report: A previously healthy 17 year male old presented in full cardiac arrest to the emergency department after a 2 day history of headache, dizziness, nausea and vomiting. Autopsy demonstrated an enlarged flabby heart with eosinophilic myocarditis. There was no interstitial pneumonia or diffuse alveolar damage. Postmortem nasopharyngeal swabs detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) known to cause coronavirus disease 2019 (COVID-19). No other cause for the eosinophilic myocarditis was elucidated.Conclusion: Like other viruses, SARS-CoV-2 may be associated with fulminant myocarditis.


Subject(s)
Coronavirus Infections/mortality , Eosinophilia/mortality , Myocarditis/mortality , Myocarditis/virology , Pneumonia, Viral/mortality , Adolescent , Betacoronavirus , COVID-19 , Coronavirus Infections/complications , Eosinophilia/complications , Fatal Outcome , Heart Arrest/complications , Heart Arrest/virology , Humans , Male , Myocarditis/complications , Pandemics , Pneumonia, Viral/complications , SARS-CoV-2
3.
Acta Paediatr ; 96(3): 464-5, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17407482

ABSTRACT

UNLABELLED: A case of a 5-month-old infant with complete duplication of the right leg and ipsilateral renal agenesis is presented. There was also a duplicated scrotum, posterior urethral valves with hydronephrosis, abnormal pelvic bones, and a ventricular septal defect. Complete caudal duplication is exceedingly rare. Associated defects are common. Several aetiological theories have been proposed. Among them, an underlying polytopic (acro-renal) developmental field defect has been suggested. It best explains the specific findings in our patient. However, the aetiology of caudal duplication syndromes may be multifactorial. In the light of twinning theories, associated duplication of hindgut derivates should be suspected in similar cases. Further research is needed. The motor-skeletal functional outcome after leg duplication surgery is mostly favourable. CONCLUSION: A case of complete unilateral leg duplication with ipsilateral renal agenesis is presented. It appears to support the theory of a polytopic developmental field defect.


Subject(s)
Abnormalities, Multiple , Kidney/abnormalities , Leg/abnormalities , Heart Septal Defects, Ventricular/etiology , Humans , Hydronephrosis/etiology , Infant , Male , Pelvis/abnormalities , Thoracic Vertebrae/abnormalities , Vesico-Ureteral Reflux/etiology
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