[Increase in NK-activity using superlow doses of the immunomodulator cycloferon]. / Povyshenie EK-aktivnosti s pomoshch'iu sverkhmalykh doz immunomoduliatora tsikloferona.

A possibility of rising the antitumor activity of natural killers using various doses of the immunomodulator cycloferon was evaluated. A direct correlation has been revealed between the killer activity and the cycloferon dose. However, on a decrease in cycloferon concentrations by several orders, as compared with commonly accepted doses, this correlation changed for inverse. A possible mechanism of this effect is discussed in addition to practical significance of the obtained results.

[The natural cytotoxicity and morphofunctional status of the surface of mononuclear cells of the blood in neurodermatitis in children]. / Estestvennaia tsitotoksichnost' i morfofunktsional'noe sostoianie poverkhnosti mononuklearov krovi pri neirodermite u detei.

Essential changes in the mononuclear glycocalix structure and function and a reduction of the blood natural cytotoxicity have been detected in children suffering from neurodermatitis. These shifts depended on the disease pattern and did not recover in clinical remission.

[Autotransfusion of UV-irradiated blood and the morphofunctional status of mononuclear cells in neurodermitis patients]. / Autotransfuziia UF-obluchennoi krovi i morfofunktsional'noe sostoianie poverkhnosti mononuklearov krovi bol'nykh neirodermitom.

Structural changes in the blood mononuclear glycocalyx has been revealed in children suffering from neurodermatitis. These shifts correlated with the cellular ability to respond to mitogenic stimulation. Treatment by UV-irradiated blood autotransfusions normalized the structure and function of mononuclears whereas routine therapy has been ineffective.

[Structural-functional characteristics of the surface of the blood mononucleocytes in children suffering from chronic dermatoses. I. The correction of the glycocalyx structure by UV irradiation of the blood and in the course of treatment with an autotransfusion of UV-irradiated blood]. / Strukturno-funktsional'nye osobennsoti poverkhnosti mononuklearov krovi detei, stradaiushchikh khronicheskimi dermatozami. I. Korrektsiia struktury glikokaliksa pri UF-obluchenii krovi i v kurse lecheniia autotransfuziei UF-obluchennoi krovi.

In children suffering from chronic dermatoses (psoriasis and neurodermatitis), the glycocalix of blood mononuclears displays an Alcian blue dye sorption by 23-25% less than that in healthy children. The UV irradiation of their blood (254 nm), in addition to a course of UV-irradiated blood autotransfusion, resulted in an elevated sorption capacity of the mononuclear glycocalix up to the normal. A possible involvement of these changes in immunocompetent cell glycocalix in the pathogenesis of chronic dermatoses is discussed, as well as the significance of glycocalix normalization in the medicinal effect of UV-irradiated blood autotransfusion.