Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
J Neurosurg Sci ; 65(3): 287-304, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33870665

ABSTRACT

INTRODUCTION: The aim of this study is to systematically review the literature on surgical revascularization techniques for flow-augmentation of the frontal areas and/or anterior cerebral artery (ACA) territory in children with Moyamoya vasculopathy (MMV), to elucidate the current surgical practice and describe the outcome associated to the different techniques. EVIDENCE ACQUISITION: The systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. MEDLINE, Web of Science and EMBASE were searched up to April 2020. Published techniques were systematically analyzed according to level of evidence, revascularization technique, opening of the interhemispheric fissure (IF), uni- or bilateral revascularization, clinical, neurocognitive, angiographic, perfusion and hemodynamic outcome. EVIDENCE SYNTHESIS: Twenty-five studies were enrolled, including 829 patients: among these, 13 patients underwent direct revascularization of ACA territories, 570 indirect revascularization and 246 patients combined revascularization. One study reached a level of evidence II (grade of recommendation B), 8 studies were level III (grade B) and 16 studies were level IV (grade C). The surgical techniques proposed in the enrolled papers were systematically described. CONCLUSIONS: Combined techniques (grade of recommendation B) and indirect techniques (grade of recommendation C) are considered effective for revascularizing the frontal areas and/or anterior cerebral artery (ACA) territory in children with MMV. While performing the revascularization, surgical risks can be reduced by avoiding the exposure of the superior sagittal sinus and opening of IF (recommendation grade C). There is not sufficient evidence to define which type of surgical technique should be preferred. Future studies are needed for a longitudinal assessment of comparable outcomes and to determine which revascularization technique for the frontal areas and/or ACA territory is optimal for this highly specific pediatric population.


Subject(s)
Cerebral Revascularization , Moyamoya Disease , Anterior Cerebral Artery/surgery , Child , Humans , Moyamoya Disease/surgery , Treatment Outcome , Vascular Surgical Procedures
2.
Invest Radiol ; 54(1): 32-38, 2019 01.
Article in English | MEDLINE | ID: mdl-30157099

ABSTRACT

OBJECTIVES: The objective of this study was to compare the diagnostic performance and confidence of conventional, optimized, and ultrashort time to echo (UTE) magnetic resonance (MR) protocols for detection of simulated lumbar spondylolysis in human cadavers. In addition, we sought to demonstrate the feasibility of the UTE technique in subjects with and without spondylolysis. MATERIALS AND METHODS: Four human lumbar spine specimens with 46 individual pars interarticularis were randomly left intact (n = 26) or received experimental osteotomy (n = 20) using a microsurgical saw to simulate spondylolysis. The specimens were imaged using a computed tomography (CT) scan along with 3 "Tiers" of MR protocols at 3 T: Tier 1, conventional lumbar MR protocol; Tier 2, optimized conventional protocol consisting of a sagittal oblique spoiled gradient recall echo and axial oblique T1 and short tau inversion recovery sequences; and Tier 3, a sagittal UTE MR sequence. Two blinded readers evaluated the images using a 4-point scale (1 = spondylolysis certainly absent, 2 = probably absent, 3 = probably present, 4 = certainly present) at each individual pars. For each imaging protocol, diagnostic performance (sensitivity, specificity, and area under the receiver operating characteristic curve, using the surgical osteotomy as the reference) and confidence were assessed and compared using the McNemar test. Furthermore, 2 human subjects were imaged with the conventional and UTE MR protocols to demonstrate feasibility in vivo. RESULTS: Diagnostic performance was moderate for Tiers 1 and 2, with a moderate sensitivity (0.70 to 0.75) and high (1.00) specificity. In contrast, CT and Tier 3 UTE MR imaging had both high sensitivity (1.00) and specificity (1.00). The sensitivities of CT or Tier 3 were statistically greater than Tier 1 sensitivity (P = 0.041) and neared statistical significance when compared with Tier 2 sensitivity (P = 0.074). Area under the receiver operating characteristic curve was also significantly greater for CT and Tier 3 (each area = 1.00), compared with the areas for Tier 1 (0.89, P = 0.037) or Tier 2 (0.873, P = 0.024). Diagnostic confidences of CT or Tier 3 were much greater than other Tiers: Both Tiers 1 and 2 had a large percentage of uncertain (>60%, P < 0.001) or wrong interpretations (>10%, P < 0.001), unlike CT or Tier 3 (0% uncertain or wrong interpretations). Preliminary in vivo UTE images clearly depicted intact and fractured pars. CONCLUSIONS: Our study demonstrated that the detection of pars fractures using a single sagittal UTE MR sequence is superior in performance and confidence to conventional and optimized MR protocols at 3 T, whereas matching those from CT evaluation. Furthermore, we demonstrated the feasibility of in vivo application of the UTE sequence in subjects with and without spondylolysis.


Subject(s)
Magnetic Resonance Imaging/methods , Spondylolysis/diagnostic imaging , Tomography, X-Ray Computed/methods , Cadaver , Female , Humans , Lumbar Vertebrae/diagnostic imaging , Male , Middle Aged , ROC Curve , Reproducibility of Results , Sensitivity and Specificity
SELECTION OF CITATIONS
SEARCH DETAIL
...