[Polyamines in microorganisms sensitive and resistant to antibiotics]. / Poliaminy u mikroorganizmov, chuvstvitel'nykh i ustoichivykh k antibiotikam

Intracellular contents of polyamine dancyl derivatives were determined by the method of thin-layer chromatography in Coli and typhoid fever bacteria sensitive to antibiotics and their variants resistant to streptomycin, levomycetin, chlortetracyline and neomycin. Increased levels of spermidine and putrescin in the antibiotic resistant cultures were found. The increased levels of the polyamines correlated with changes in the content of nucleic acids. It is supposed that the increase in the content of the polyamines in the antibiotic resistant bacteria was the result of accumulation of nucleic acids by them.

[Humoral indices of immunologic reactivity in the evaluation of the state of patients with cholecystitis before and after surgery]. / Gumoral'nye pokazateli immunologicheskoi reaktivnosti v otsenke sostoianiia bol'nykh kholetsistitom do i posle operatsii

As a result of studies of the complement and serum lysozyme titra, as well as its bactericide index in 250 patients with cholecystitis, it was found that inflammatory lesions of the bile outflow system were accompanied with a considerable reduction of humoral indices of natural immunity, the degree of this decrease being dependent on a gravity of the disease clinical course and a duration of the inflammatory process. Prompt normalization of the immune response factors postoperatively indicated the favourable outcome. Persistant inhibition of the humoral factors activity in most patients preceded the development of clinical signs of complications.

[Theoretically probable assessment of the effectiveness of individualized combined antibiotic therapy of patients with suppurative inflammatory processes]. / Teoretiko-veroiatnostnaia otsenka éffektivnosti individualizovannoi kombinirovannoi antibiotikoterapii bol'nykh s gnoino-vospalitel'nymi protsessami

Efficiency of individual combined antibiotic therapy of patients was estimated in comparison to the use of single antibiotics of their fixed combinations without any special control group. Since the essence of the study was practically in successive appliance of the 2 methods of therapy to the same group of the patients, it was possible to carry out theoretically probable estimation of the final result as a summation effect of both methods and to define the probable result of the 2 nd method. The study of the results of the treatment of the patients with purulent-inflammatory processes showed significant advantages of the individual combined antibiotic therapy.