The inquisitorial censorship ofamatus lusitanus centuriae / La censura inquisitorial en las Centurias de Amatus Lusitanus

We analyse the inquisitorial censorship expressed in expurgations of some excerpts of the Centuriae of Medicinal Cures, authored by the Portuguese physician João Rodrigues de Castelo Branco (1511-1568), better known as Amatus Lusitanus. Our sources were the Centuriae II, III and IV (bound together, Florence, 1551) and the Centuria VII (Venice, 1566), both kept in the General Library of the University of Coimbra, Portugal. For the reconstitution of the texts we resorted to other editions available online and to the modern Portuguese translation, prepared from the Bordeaux edition of 1620. We conclude that most of the censored excerpts refer to affections of sexuality, gynaecology and obstetrics, the remaining being related to matters of strictly religious nature

En este artículo analizamos la censura inquisitorial expresada en expurgaciones de algunos extractos de Centurias de Curas Medicinales, escrito por el médico portugués João Rodrigues de Castelo Branco (1511-1568), más conocido como Amatus Lusitanus. Nuestras fuentes han sido las Centurias II, III y IV (atadas juntas, Florencia, 1551) y Centuria VII (Venecia, 1566), ambas conservadas en la Biblioteca General de la Universidad de Coimbra, Portugal. Para la reconstitución de los textos recurrimos a otras ediciones disponibles online y a la nueva traducción portuguesa, preparada a partir de la edición de Burdeos de 1620. Concluimos que la mayoría de los extractos censurados se refieren a afecciones de sexualidad, ginecología y obstetricia, el resto se relacionan con asuntos de naturaleza estrictamente religiosa

[Medical teaching at the Universidade de Coimbra in the sixteenth century]. / O ensino da medicina na Universidade de Coimbra no seculo XVI.

The article addresses the teaching of medicine at the Universidade de Coimbra in the sixteenth century, framing it within the Portuguese and European context and highlighting the contributions of the institution's key professors - Enrique de Cuellar, Tomás Veiga, Alfonso de Guevara, and João Bravo Chamisso - along with their main works. Following a historical overview, the study analyzes the reforms of Dom Manuel I and Dom João III, the role of anatomy in the renewal of medical studies, the relation with the Discoveries, the obstacles raised by the Inquisition, medical practice at hospitals, and, lastly, the decline of medical teaching. Although they did not teach at Coimbra, reference is made to the two greatest names in sixteenth-century Portuguese medicine: Amato Lusitano and Garcia da Orta.

O ensino da medicina na Universidade de Coimbra no seculo XVI / Medical teaching at the Universidade de Coimbra in the sixteenth century

Apresenta o ensino da medicina na Universidade de Coimbra no século XVI, enquadrando-o no contexto português e europeu e apontando o contributo dos principais professores - Enrique de Cuellar, Tomás Veiga, Alfonso de Guevara e João Bravo Chamisso - , assim como suas obras mais relevantes. Depois de expor a história prévia, são analisadas as reformas de dom Manuel I e de dom João III, o papel da anatomia na renovação dos estudos médicos, a relação com os Descobrimentos, as dificuldades levantadas pela Inquisição, a prática nos hospitais e, finalmente, o declínio do ensino da medicina. Apesar de não terem sido professores em Coimbra, faz-se referência aos dois maiores nomes da medicina portuguesa no século XVI, Amato Lusitano e Garcia da Orta.

The article addresses the teaching of medicine at the Universidade de Coimbra in the sixteenth century, framing it within the Portuguese and European context and highlighting the contributions of the institution's key professors - Enrique de Cuellar, Tomás Veiga, Alfonso de Guevara, and João Bravo Chamisso - along with their main works. Following a historical overview, the study analyzes the reforms of Dom Manuel I and Dom João III, the role of anatomy in the renewal of medical studies, the relation with the Discoveries, the obstacles raised by the Inquisition, medical practice at hospitals, and, lastly, the decline of medical teaching. Although they did not teach at Coimbra, reference is made to the two greatest names in sixteenth-century Portuguese medicine: Amato Lusitano and Garcia da Orta.

Density functional theory study of the oxoperoxo vanadium(V) complexes of glycolic acid. Structural correlations with NMR chemical shifts.

The DFT B3LYP/SBKJC method has been used to calculate the gas-phase optimized geometries of the glycolate oxoperoxo vanadium(V) complexes [V(2)O(2)(OO)(2)(gly)(2)](2-), [V(2)O(3)(OO)(gly)(2)](2-) and [VO(OO)(gly)(H(2)O)](-). The (51)V, (17)O, (13)C and (1)H chemical shifts have been calculated for the theoretical geometries in all-electron DFT calculations at the UDFT-IGLO-PW91 level and have been subsequently compared with the experimental chemical shifts in solution. In spite of being applied to the isolated molecules, the calculations allowed satisfactory reproduction of the multinuclear NMR solution chemical shifts of the complexes, suggesting that the theoretical structures are probably close to those in solution. The effects of structural changes on the (51)V and (17)O NMR chemical shifts have been analysed using the referred computational methodologies for one of the glycolate complexes and for several small molecules taken as models. These calculations showed that structural modifications far from the metal nucleus do not significantly affect the metal chemical shift. This finding explains why it is possible to establish reference scales that correlate the type of complex (type of metal centre associated with a certain type of ligand) with its typical region of metal chemical shifts. It has also been found that the V[double bond, length as m-dash]O bond length is the dominant geometrical parameter determining both delta(51)V and the oxo delta(17)O in this kind of complex.

Oxoperoxo vanadium(V) complexes of L-lactic acid: density functional theory study of structure and NMR chemical shifts.

Various combinations of density functionals and pseudopotentials with associated valence basis-sets are compared for reproducing the known solid-state structure of [V 2O 2(OO) 2 l-lact 2] (2-) cis . Gas-phase optimizations at the B3LYP/SBKJC level have been found to provide a structure that is close to that seen in the solid state by X-ray diffraction. Although this may result in part from error compensation, this optimized structure allowed satisfactory reproduction of solution multinuclear NMR chemical shifts of the complex in all-electron DFT-IGLO calculations (UDFT-IGLO-PW91 level), suggesting that it is probably close to that found in solution. This combination of approaches has subsequently been used to optimize the structures of the vanadium oxoperoxo complexes [V 2O 3(OO) l-lact 2] (2-) cis , [V 2O 3(OO) l-lact 2] (2-) trans , and [VO(OO)( l-lact)(H 2O)] (-) cis . The (1)H, (13)C, (51)V, and (17)O NMR chemical shifts for these complexes have been calculated and compared with the experimental solution chemical shifts. Excellent agreement is seen with the (13)C chemical shifts, while somewhat inferior agreement is found for (1)H shifts. The (51)V and (17)O chemical shifts of the dioxo vanadium centers are well reproduced, with differences between theoretical and experimental shifts ranging from 22.9 to 35.6 ppm and from 25.1 to 43.7 ppm, respectively. Inferior agreement is found for oxoperoxo vanadium centers, with differences varying from 137.3 to 175.0 ppm for (51)V shifts and from 148.7 to 167.0 ppm for (17)O(oxo) shifts. The larger errors are likely to be due to overestimated peroxo O-O distances. The chosen methodology is able to predict and analyze a number of interesting structural features for vanadium(V) oxoperoxocomplexes of alpha-hydroxycarboxylic acids.