ABSTRACT
Reactivities of the monoclonal antibodies (mAbs) of the 9th Human Leukocyte Differentiation Antigen Workshop, in order to define specific antigenic expression of the primary cutaneous B-cell lymphomas (PC-BCL), were analyzed by immunohistology on human tonsil and on PC-BCL, such as follicular centre B-cell lymphomas (FCL), marginal zone lymphomas (MZL) and diffuse large B-cells lymphomas leg-type (DLBL-LT). We identified some subgroups of mAbs that were exclusively or preferentially positive in one lymphoma cell type: the PC-FCL subgroup of mAbs includes PD1/CD279, GCET-1, hFCRL1/CD307a, FCRL2/CD307b, CXCR5/CD185, B7-DC/CD273, MRC/CD200, CD130, CXCR4/CD184, Siglec-5/14, CD150, on the other hand subgroup of mAbs in PC-MZL includes BTLA/CD272, BLIMP-1, hCD38. No specific subgroup of mAbs was found to label PC-DLBCL. This study may be useful to better define specific antigen profile of different PC-BCL entities leading to a correct diagnosis.
Subject(s)
Antibodies, Monoclonal/immunology , Antigens, Differentiation, B-Lymphocyte/immunology , Biomarkers, Tumor , Lymphoma, B-Cell/diagnosis , Lymphoma, B-Cell/immunology , Skin Neoplasms/diagnosis , Skin Neoplasms/immunology , Biomarkers, Tumor/analysis , Biomarkers, Tumor/immunology , Humans , Immunophenotyping , Lymphoma, B-Cell/pathology , Palatine Tonsil/cytology , Palatine Tonsil/immunology , Skin Neoplasms/pathologyABSTRACT
The case of a 48-year old woman with a lymph node localization of gastrinoma is reported. The preoperative workup (US-scan, TC-scan and NMR) made it possible to detect and localize the lesion. A conservative surgical approach was decided according to the latest literature reports which showed a favourable course in patients with lymph node gastrinoma. Surgical resection has been accomplished. The patient's hormone level was normal at one-year follow-up.
Subject(s)
Gastrinoma/diagnosis , Lymph Nodes , Pancreatic Neoplasms/diagnosis , Female , Gastrinoma/diagnostic imaging , Gastrinoma/surgery , Humans , Magnetic Resonance Imaging , Middle Aged , Pancreatic Neoplasms/diagnostic imaging , Pancreatic Neoplasms/surgery , Tomography, X-Ray Computed , UltrasonographyABSTRACT
The authors report a case of gastro-intestinal bleeding due to arteriovenous malformation of the right colon: the angiodysplasia (AVMs-Moore's type 1). The investigations usually adopted in case of G.I. bleeding (x-Ray-examinations and endoscopy) are often unable to define the diagnosis. In this report the diagnostic importance of selective angiography in patients with lower intestinal blood loss is emphasized.
