Subject(s)
Cardiac Resynchronization Therapy/methods , Cardiomyopathy, Dilated , Cardiovascular Agents/therapeutic use , Heart Failure , Cardiomyopathy, Dilated/complications , Cardiomyopathy, Dilated/diagnosis , Disease Progression , Echocardiography/methods , Electrocardiography/methods , Female , Gadolinium , Heart Failure/diagnosis , Heart Failure/etiology , Heart Failure/physiopathology , Heart Failure/therapy , Humans , Magnetic Resonance Imaging/methods , Middle Aged , Severity of Illness Index , Treatment OutcomeABSTRACT
The effect of Ritmilen and allapinin, a new Soviet antiarrhythmic drug, on hemodynamics and myocardial contractility were evaluated in 36 patients with various heart rhythm disorders during diagnostic coronary angiography. Ritmilen has been shown to have an essential cardiodepressive effect. An intravenous 150 mg dose of Ritmilen results in a depression of dp/dtmax, Veragut's index, ejection fraction, mean standard circular fibre shortening rate, and increase in left ventricular systolic and end diastolic pressure, total peripheral resistance and mean arterial blood pressure. Allapinin (30 mg) has no marked cardiodepressive effect, as compared to Ritmilen.
Subject(s)
Aconitine/analogs & derivatives , Anti-Arrhythmia Agents/therapeutic use , Arrhythmias, Cardiac/drug therapy , Disopyramide/therapeutic use , Hemodynamics/drug effects , Myocardial Contraction/drug effects , Adult , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/physiopathology , Depression, Chemical , Drug Evaluation , Female , Humans , Male , Middle AgedABSTRACT
Blood endogenous prostaglandins, E, F2 alpha, prostacyclin and thromboxane levels were measured in the ascending aorta and the coronary sinus of 32 patients (29 males and 3 females) with paroxysmal supraventricular arrhythmias (atrial fibrillation and supraventricular tachycardia) during the sinus rhythm and an arrhythmic paroxysm. Group 1 was made up by 22 patients with idiopathic cardiac rhythm disorders, and group 2 comprised 10 coronary patients with arrhythmias. A relationship was demonstrated between cardiac endogenous prostanoids balance and the clinical pattern of cardiac rhythm abnormality (duration and frequency of paroxysms) as well as changes in cardiac prostanoid rations associated with tachyarrhythmic paroxysms.
Subject(s)
Prostaglandins/blood , Tachycardia, Paroxysmal/blood , Tachycardia, Supraventricular/blood , 6-Ketoprostaglandin F1 alpha/blood , Adult , Chronic Disease , Coronary Disease/blood , Dinoprost , Female , Humans , Male , Middle Aged , Prostaglandins E/blood , Prostaglandins F/blood , Thromboxane B2/bloodSubject(s)
Arrhythmias, Cardiac/physiopathology , Myocardium/metabolism , Water-Electrolyte Balance , Adult , Arteries , Coronary Disease/physiopathology , Electrolytes/blood , Female , Heart Rate , Humans , Male , Middle Aged , VeinsABSTRACT
The authors studied the status and changes in the myocardial blood flow volume in 25 patients with supraventricular cardiac arrhythmias in the presence of coronary heart disease and without organic abnormalities on the part of the cardiovascular system. As regards the status of the sinus rhythm, the total myocardial blood flow in patients with idiopathic rhythm disturbances versus coronary heart disease showed no significant differences. In conditions of electrostimulation-induced tachyarrhythmia, patients with idiopathic arrhythmias exhibited a linear increase in the blood flow in the basin of both coronary arteries while in the coronary heart disease patients there were heterogeneous alterations of the myocardial blood flow with a general downward trend. In patients with the idiopathic form of continuous fibrillations with the comparable heart rate the values of the myocardial blood flow are significantly lower than in patients with idiopathic paroxysmal tachyarrhythmia. The decrease of the coronary blood flow observed in tachycardia is believed to result from an increased coronary vascular resistance which points to a reduction of the reserve capabilities of the coronary bed in relation to its dilatation.
