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1.
HNO ; 61(9): 762-71, 2013 Sep.
Article in German | MEDLINE | ID: mdl-23979117

ABSTRACT

In most patients with vertigo, the first and clinically most important question posed to neurologists is whether it is a central or a peripheral syndrome. In more than 90 % of cases, this differentiation is made possible by systematically recording the patient history (asking about the type of vertigo, the duration, triggers and accompanying symptoms) and conducting a physical examination. Particularly in the case of acute vertigo disorders, a five-step procedure has proven useful: 1. A cover test to look for vertical divergence (skew deviation) as a central sign and component of the ocular tilt reaction (OTR); 2. Examination with and without Frenzel goggles to differentiate between peripheral vestibular spontaneous nystagmus and central fixation nystagmus; 3. Examination of smooth pursuit; 4. Examination of the gaze-holding function (particularly gaze-evoked nystagmus beating in the opposite direction to spontaneous nystagmus); 5. The head impulse test to look for a deficit in the vestibulo-ocular reflex (VOR). Considerable advances have been made in the pharmacotherapy of vertigo disorders during the last 10 years, including cortisone for the treatment of acute vestibular neuritis, betahistine as a high-dose long-term treatment for Menière's disease, carbamazepine to treat vestibular paroxysmia and aminopyridine for down- and upbeat nystagmus and episodic ataxia type 2.


Subject(s)
Brain Diseases/diagnosis , Diagnostic Techniques, Neurological , Medical History Taking/methods , Vertigo/diagnosis , Vestibular Function Tests/methods , Vision Disorders/diagnosis , Vision Tests/methods , Brain Diseases/complications , Diagnosis, Differential , Humans , Vertigo/etiology , Vision Disorders/complications
2.
Z Kardiol ; 93(2): 124-30, 2004 Feb.
Article in English | MEDLINE | ID: mdl-14963678

ABSTRACT

Calcific aortic stenosis is the main heart valve disease in the elderly, leading to massive focal calcification and thickening of the valve cusps. Matrix metalloproteinases (MMPs) are thought to contribute to this process. Therefore, the study assessed the expression of the gelatinases MMP-2 and MMP-9 and the endogenous tissue inhibitor of metalloproteinase (TIMP)-2 as well as the gelatinolytic activity in normal and stenotic valves. Human tricuspid aortic valves with and without calcific aortic stenosis were studied by immunohistochemistry for MMP-2, MMP-9 and TIMP-2. The gelatinolytic activity in native valve sections was assessed by gelatin in situ zymography with or without addition of the MMP activator p-aminophenymercuric acetate (APMA). Staining intensities for MMP-2 and TIMP-2 were elevated in stenotic valves as compared to controls. Minor staining of MMP-9 was present exclusively in stenotic valves. The morphologic distribution of gelatinolytic activity was comparable to the staining pattern of MMP-2, and since MMP-9 immunostaining demonstrated only a low number of positive cells, the observed gelatinolytic activity is likely due to MMP-2. Gelatinolytic activity was low in normal valves but significantly increased by the MMP activator APMA. In contrast, stenotic valves showed a strong basal gelatinolytic activity that could not be significantly enhanced by APMA suggesting that MMP-2 is present as a latent pro-enzyme in normal valves and activated in stenotic valves. Thus, MMP-2 might be involved in the matrix remodeling during calcific aortic stenosis.


Subject(s)
Aortic Valve Stenosis/pathology , Aortic Valve/pathology , Calcinosis/pathology , Matrix Metalloproteinase 2/analysis , Aortic Valve Stenosis/surgery , Calcinosis/surgery , Heart Valve Prosthesis Implantation , Humans , Immunoenzyme Techniques , Matrix Metalloproteinase 9/analysis , Reference Values , Tissue Inhibitor of Metalloproteinase-2/analysis
3.
Science ; 263(5150): 1161-2, 1994 Feb 25.
Article in English | MEDLINE | ID: mdl-17831632
4.
Science ; 252(5008): 981-4, 1991 May 17.
Article in English | MEDLINE | ID: mdl-17843236
5.
Science ; 238(4830): 1152-3, 1987 Nov 20.
Article in English | MEDLINE | ID: mdl-17839370
7.
Br J Sociol ; 27(1): 35-49, 1976 Mar.
Article in English | MEDLINE | ID: mdl-1268455
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