Subject(s)
Amiodarone/adverse effects , Anti-Arrhythmia Agents/adverse effects , Facial Dermatoses/chemically induced , Hyperpigmentation/chemically induced , Vasodilator Agents/adverse effects , Aged , Amiodarone/administration & dosage , Anti-Arrhythmia Agents/administration & dosage , Biopsy , Diagnosis, Differential , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Humans , Hyperpigmentation/diagnosis , Hyperpigmentation/pathology , Male , Skin/pathology , Time Factors , Vasodilator Agents/administration & dosageABSTRACT
The use of different low dose ultrasound systems is an innovative and effective alternative strategy of treatment in wound bed preparation of different chronic wounds. The handling of the ultrasonic systems is easy to learn, their use is safe and little additional equipment is required. Induction of the so called cavitation phenomenon seems to be a major effect which permits selective debridement and reduction of microorganism colonisation. While the suggestion is that granulation tissue is promoted and wound healing accelerated, there are few well documented evidence-based data. Additional randomized controlled trials are needed before the therapeutic efficacy of ultrasound in this clinical setting can be evaluated.
Subject(s)
Leg Ulcer/therapy , Ultrasonic Therapy , Wound Infection/therapy , Wounds and Injuries/therapy , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Chronic Disease , Clinical Trials as Topic , Combined Modality Therapy , Debridement , Granulation Tissue , Humans , Leg Ulcer/drug therapy , Placebos , Randomized Controlled Trials as Topic , Time Factors , Transducers , Ultrasonic Therapy/instrumentation , Ultrasonic Therapy/methods , Wound Healing , Wound Infection/drug therapy , Wound Infection/microbiology , Wounds and Injuries/drug therapy , Wounds and Injuries/microbiologySubject(s)
Carrier Proteins/metabolism , Hydrogen-Ion Concentration , Liver/metabolism , Animals , Biological Transport , Cells, Cultured , Ions , Kinetics , Models, Biological , RatsABSTRACT
In patients with lupus nephropathy (LN), previous studies have shown that creatinine clearance (CCr) overestimates true glomerular filtration rate as measured by inulin clearance (CIn), and that among patients the degree of overestimation is highly variable. We sought to determine whether the discrepancy between CCr and CIn remains constant over time (months, years) in each individual patient, and therefore whether serial measurements of CCr reliably reflect the direction and magnitude of change in CIn. Twenty-five patients with LN underwent simultaneous determinations of CCr and CIn performed two to four (mean 3.3) times over three years. In a given patient, it was found that the ratio of CCr/CIn changed substantially over time (mean SD 0.16 with 95% confidence interval of 0.12 to 0.20). Thus, in about 32% of cases the ratio of CCr/CIn will vary more than +/- 16% from a previously measured value of CCr/CIn. Patients with both high and low values of CIn showed similar variability in CCR/CIn over time. Variability in CCr/CIn was found regardless of whether CIn was increasing, decreasing, or constant over time. In nearly one-half of all measurements of CCr, the corresponding change in CIn was directionally discordant. Iothalamate and technetium-DTPA renal clearances correlated highly with CIn (R2 = 0.99). We conclude that the discrepancy between CCr and CIn can vary greatly over time in an individual patient. Consequently, serial CCr does not accurately measure the direction or magnitude of change in glomerular filtration rate in lupus nephropathy.
