The spectrum of glomerular disease between the years 2003 and 2015 in Columbia: A review of 12,613 cases.

BACKGROUND: The prevalence of glomerular disease (GD) varies according to the different socio-demographic characteristics of each population. For the first time we present the prevalence of the different forms of GD among patients from several different areas of Columbia. METHODS: Data from 12,613 renal biopsies studied at our University Hospital between 2003 and 2015 was reviewed. Pathology results were classified according to a list of renal diseases proposed by various authors. RESULTS: Focal segmental glomerulosclerosis was present in 22%, IgA disease in 21%, Lupus nephritis in 17%, membranous glomerulonephritis in 13% and thin basal membrane disease in 9%. CONCLUSIONS: This study confirms that focal segmental glomerulosclerosis and IgA disease are the most prevalent GDs found in Columbian patients. This is the first study to analyze GDs in a Columbian population and we recommend that a national registry system be created to collect comprehensive information from future research.

The spectrum of glomerular disease between the years 2003 and 2015 in Columbia: a review of 12.613 cases / El espectro de enfermedades glomerulares entre los años 2003 y 2015 en Colombia: una revisión de 12.613 casos

Background. The prevalence of glomerular disease (GD) varies according to the different socio-demographic characteristics of each population. For the first time we present the prevalence of the different forms of GD among patients from several different areas of Columbia. Methods. Data from 12,613 renal biopsies studied at our University Hospital between 2003 and 2015 was reviewed. Pathology results were classified according to a list of renal diseases proposed by various authors. Results. Focal segmental glomerulosclerosis was present in 22%, IgA disease in 21%, Lupus nephritis in 17%, membranous glomerulonephritis in 13% and thin basal membrane disease in 9%. Conclusions. This study confirms that focal segmental glomerulosclerosis and IgA disease are the most prevalent GDs found in Columbian patients. This is the first study to analyze GDs in a Columbian population and we recommend that a national registry system be created to collect comprehensive information from future research (AU)

Antecedentes. La prevalencia de las enfermedades glomerulares varía según las características sociodemográficas de cada población. Por primera vez presentamos la prevalencia de las diferentes formas de enfermedad glomerular (EG) entre pacientes de varias regiones de Colombia. Método. Se revisaron los datos de 12.613 biopsias renales estudiadas en nuestro hospital universitario entre los años 2003 y 2015. Se clasificaron los resultados anatomopatológicos según una lista de enfermedades renales propuesta por varios autores. Resultados. Se encontró glomeruloesclerosis focal y segmentaria en el 22%, enfermedad IgA en el 21%, nefritis lupoide en el 17%, glomerulonefritis membranosa en el 13% y enfermedad de la membrana basal delgada en el 9%. Conclusiones. Nuestro estudio confirma que la glomeruloesclerosis focal y segmentaria y la enfermedad IgA son los más prevalentes entre pacientes colombianos. Esto es el primer estudio que ha analizado EG en la población colombiana, y recomendamos la creación de un registro nacional para recopilar y completar información de investigaciones futuras (AU)

Hemolytic uremic syndrome due to gemcitabine in a young woman with cholangiocarcinoma. / Síndrome hemolítico-urêmica causada por gencitabina em uma paciente jovem com colangiocarcinoma.

Gemcitabine is a medication used to treat various types of malignant neoplasms. Its association with hemolytic uremic syndrome (HUS) has been described in few cases, although these cases have resulted in mortality rates of at least 50%. We report on the case of a 25-year-old patient with cholangiocarcinoma in remission who developed microangiopathic hemolytic anemia with acute anuric renal failure after receiving 5 cycles of gemcitabine chemotherapy; this condition was consistent with HUS caused by the side effects of this drug. The administration of gemcitabine was stopped, and hemodialysis, blood transfusions, plasma exchanges, steroids, doxycycline, and rituximab were used to treat the patient. A favorable outcome was achieved; in particular, hemolysis was controlled, and renal function was completely recovered.

Síndrome hemolítico-urêmica causada por gencitabina em uma paciente jovem com colangiocarcinoma / Hemolytic uremic syndrome due to gemcitabine in a young woman with cholangiocarcinoma

Resumo A gencitabina é um fármaco utilizado no tratamento de vários tipos de neoplasias malignas. Há poucas descrições de associação entre a droga e a síndrome hemolítico-urêmica (SHU), apesar de os pacientes em questão terem ido a óbito em pelo menos 50% dos casos. O presente artigo relata o caso de uma paciente com 25 anos de idade em remissão diagnosticada com colangiocarcinoma que apresentou anemia hemolítica microangiopática acompanhada de insuficiência renal aguda anúrica após cinco ciclos de quimioterapia com gencitabina; as manifestações eram condizentes com SHU causada pelos efeitos colaterais do medicamento. A administração de gencitabina foi interrompida, e a paciente foi tratada com hemodiálise, transfusões de sangue, trocas de plasma, corticosteroides, doxiciclina e rituximabe. Foi atingido um desfecho favorável; mais especificamente, a hemólise foi controlada e a função renal foi plenamente restabelecida.

Abstract Gemcitabine is a medication used to treat various types of malignant neoplasms. Its association with hemolytic uremic syndrome (HUS) has been described in few cases, although these cases have resulted in mortality rates of at least 50%. We report on the case of a 25-year-old patient with cholangiocarcinoma in remission who developed microangiopathic hemolytic anemia with acute anuric renal failure after receiving 5 cycles of gemcitabine chemotherapy; this condition was consistent with HUS caused by the side effects of this drug. The administration of gemcitabine was stopped, and hemodialysis, blood transfusions, plasma exchanges, steroids, doxycycline, and rituximab were used to treat the patient. A favorable outcome was achieved; in particular, hemolysis was controlled, and renal function was completely recovered.