1.
J Med Chem
; 18(3): 245-50, 1975 Mar.
Article
in English
| MEDLINE
| ID: mdl-1133813
ABSTRACT
Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach.
Subject(s)
Antiviral Agents/chemical synthesis , Quinolines/chemical synthesis , Animals , Antiviral Agents/therapeutic use , Coxsackievirus Infections/drug therapy , Herpes Simplex/drug therapy , Hydrazones/chemical synthesis , Hydrazones/therapeutic use , Kinetics , Mice , Orthomyxoviridae Infections/drug therapy , Quinolines/therapeutic use , Structure-Activity Relationship
2.
Proc Soc Exp Biol Med
; 141(2): 475-8, 1972 Nov.
Article
in English
| MEDLINE
| ID: mdl-4344266
Subject(s)
Antiviral Agents/pharmacology , Indoles/pharmacology , Picornaviridae/drug effects , Administration, Intranasal , Administration, Oral , Aerosols , Antiviral Agents/administration & dosage , Carbon Isotopes , Dose-Response Relationship, Drug , Enterovirus/drug effects , HeLa Cells , Indoles/administration & dosage , Interferon Inducers/pharmacology , Mengovirus/drug effects , Poliovirus/drug effects , Protein Binding , Rhinovirus/drug effects , Vaccinia virus/drug effects , Virus Replication/drug effects
3.
Antimicrob Agents Chemother (Bethesda)
; 8: 194-200, 1968.
Article
in English
| MEDLINE
| ID: mdl-5753824
