Subject(s)
Cell Transformation, Neoplastic/pathology , Extracellular Matrix/physiology , Fibronectins/physiology , Neoplasm Metastasis/pathology , Neoplasms/pathology , Receptors, Fibronectin/physiology , Cell Adhesion/physiology , Cell Differentiation/physiology , Extracellular Matrix/ultrastructure , Humans , Neoplasm Invasiveness , Neoplasm Metastasis/physiopathology , Neoplasm Metastasis/ultrastructure , Neoplasms/etiology , Neoplasms/ultrastructureABSTRACT
The influence of silicon treatment on the levels of lipid parameters of blood serum and aortic wall was studied in rats. The concentrations of total cholesterol, phospholipids, triglycerides, HDL-cholesterol, LDL-cholesterol, and HDL-phospholipids were measured in sera of rats receiving per os a soluble, inorganic silicon compound--sodium metasilicate nonahydrate (Na2SiO3.9H2O)--dissolved in the drinking water. In the aortic tissue levels of total cholesterol, triglycerides and phospholipids were estimated. An increase in HDL-cholesterol and HDL-phospholipid concentrations, with a simultaneous decrease of LDL-cholesterol and triglyceride levels, was observed in the sera of the tested group. The levels of total cholesterol and phospholipids in the sera, as well as the concentrations of lipids in the aortic walls, showed no significant differences. The results obtained could provide evidence for the existence of an additional mechanism of silicon antiatheromatous action, concerning the modification of activity of enzymatic systems involved in lipids metabolism.
Subject(s)
Aorta/metabolism , Lipid Metabolism , Muscle, Smooth, Vascular/metabolism , Silicon/pharmacology , Animals , Aorta/drug effects , Cholesterol/blood , Cholesterol/metabolism , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Lipids/blood , Male , Muscle, Smooth, Vascular/drug effects , Phospholipids/blood , Phospholipids/metabolism , Rats , Rats, Inbred Strains , Reference Values , Triglycerides/blood , Triglycerides/metabolismABSTRACT
Tissue plasminogen activator (t-PA) is the main physiological activator of the fibrinolysis process present in nearly all organs, tissues and secretions. Its most important function is dissolving of intervascular fibrin deposits. T-PA is synthesized and secreted by the endothelium of blood vessels in response to various stimuli. Its enzymatic activity in plasma is controlled by rapidly acting inhibitors. Reduced generation of t-PA activity may be the cause of thrombotic changes in the vascular system. Studies are conducted presently on the use of t-PA in thrombolytic treatment.
Subject(s)
Fibrinolysis/physiology , Thrombolytic Therapy , Thrombosis/drug therapy , Tissue Plasminogen Activator/physiology , Endothelium, Vascular/drug effects , Endothelium, Vascular/enzymology , Endothelium, Vascular/metabolism , Fibrinolysis/drug effects , Humans , Thrombosis/etiology , Tissue Plasminogen Activator/deficiency , Tissue Plasminogen Activator/therapeutic useABSTRACT
Ultrasound waves play an important part in contemporary diagnosis and medical therapy. The effect of the ultrasounds used in medicine, on the course of the metabolic processes of the human organism exposed to the activity of ultrasounds is not known. An experiment was carried out to detect the early influence of ultrasonographic (USG) examination of the abdominal cavity on the concentration of the lipid system parameters in the blood serum of healthy subjects. A statistically significant decrease in the concentration of triglycerides and free fatty acids was noted 2 hours after USG examination. No change of concentration of total cholesterol and beta-lipoproteins was observed. The mechanisms of the interaction between ultrasounds and living matter are discussed.
