ABSTRACT
OBJECTIVE: To evaluate the efficacy and safety profile of one 30-mg nimodipine oral tablet taken three times per day (one tablet with breakfast, one with lunch, and one with dinner) or one 150-mg cinnarizine verum oral capsule taken once each day with dinner for 12 weeks. STUDY DESIGN: Comparative in a double-blind, multinational pilot study. SETTING: Tertiary referral center. PATIENTS: A total of 221 patients met the study criteria; of that total, 181 adult patients completed the study, including 135 women and 46 men whose ages ranged from 20 to 80 years. INTERVENTIONS: Two calcium antagonists were used to treat vertigo (nimodipine, 89 patients; cinnarizine, 92 patients), and all patients were maintained on the same dosage regimen until they completed 12 weeks of treatment. Patients were evaluated at 2-and 4-week intervals; an additional evaluation was made at Week 14 to determine vertigo recurrence in the posttreatment period. MAIN OUTCOME MEASURES: The response was evaluated by using the vertigo severity index, a count of vertigo episodes in a given time period. Each episode is weighted according to its intensity. RESULTS: Nimodipine treatment decreased the incidence of moderate vertigo episodes by 78.8% and decreased severe vertigo episodes by 85.0%. Cinnarizine treatment decreased the incidence of moderate vertigo episodes by 65.8% and decreased severe vertigo episodes by 89.8%. Nimodipine and cinnarizine exhibited similar safety profiles. Only two patients withdrew from the study because of adverse events possibly related to the study drug. One patient withdrew from the cinnarizine group because of headache, and one patient withdrew from the nimodipine group because of lipothymia. CONCLUSION: These data confirm the marked efficacy of both nimodipine and cinnarizine in the treatment of vestibular vertigo.
Subject(s)
Calcium Channel Blockers/administration & dosage , Cinnarizine/therapeutic use , Nimodipine/therapeutic use , Vertigo/drug therapy , Adult , Aged , Aged, 80 and over , Calcium Channel Blockers/adverse effects , Calcium Channel Blockers/therapeutic use , Cinnarizine/administration & dosage , Cinnarizine/adverse effects , Drug Administration Schedule , Electronystagmography , Female , Humans , International Cooperation , Male , Middle Aged , Nimodipine/administration & dosage , Nimodipine/adverse effects , Pilot Projects , Recurrence , Severity of Illness Index , Vertigo/physiopathologyABSTRACT
El objetivo de este estudio fue evaluar la eficacia y seguridad de la nimodipina en pacientes con demencia degenerativa primaria tipo Alzheimer (PDD-AD) y demencia vascular debido a infartos múltiples (MID). Este fue el primer estudio abierto latinoamericano, multinacional multicéntrico, con un período de duración de 12 semanas. El seguimiento incluyó una evaluación basal y luego cada cuatro semanas, con una serie de pruebas tanto cognitivas (Mini Mental State Examination (MMSE) y Trail Marking Test (TMT-A), como escalas de comportamiento y funcionalidad (Sandoz Clinical Assesment Geriatric Scale (SSCAG) y Assessment of Geriatric Symtoms (RAGS-E)
Subject(s)
Humans , Male , Female , Middle Aged , Dementia, Multi-Infarct/therapy , Nimodipine/therapeutic use , Latin AmericaSubject(s)
Adult , Humans , Male , Female , Enoxacin/therapeutic use , Haemophilus Infections/transmission , Carrier StateABSTRACT
Se estudian 63 casos de rotura uterina (R.U.) ocurridos en el Hospital San Juan de Dios entre 1961 y 1985, analizándose una serie de parámetros. Resalta que este accidente sobrevino en un número significativo de primíparas. Uno de los factores predisponentes más importantes resultó ser el antecedente de cicatriz uterina, especialmente de operación cesárea, y la manifestación clínica más relevante, la hemorragia. Hubo una mortalidad materna de 12,7%, y perinatal de 24,0%. Se observó una tendencia al aumento de la incidencia de este accidente en los últimos años, al parecer en relación con la tendencia actual al incremento de la operación cesárea