ABSTRACT
High level of polyamine oxidase activity is detected in sera of depressed as well as in schizophrenic patients. ECT treatment of depressed and schizophrenic patients reduced significantly the level of polyamine oxidase activity in their sera. After ECT treatment, clinically improved depressed and schizophrenic subjects were found to have sera polyamine oxidase activity not significantly differ from that of normal subjects. Possible biochemical mechanisms, which link polyamine oxidase activity, schizophrenia, depression and ECT effect are discussed here.
Subject(s)
Depression/enzymology , Electroconvulsive Therapy , Oxidoreductases Acting on CH-NH Group Donors/blood , Schizophrenia/enzymology , Depression/blood , Depression/therapy , Humans , Schizophrenia/blood , Schizophrenia/therapy , Polyamine OxidaseABSTRACT
Spermidine oxidase activity in human serum is distributed over a relatively wide range, with a highly significant difference between normal and schizophrenic subjects. The enzyme activity showed no age- or sex-related differences. It is largely inhibited by quinacrine and chloroquine.
