Subject(s)
Carbon , Membranes, Artificial , Chemical Phenomena , Chemistry, Physical , UltrafiltrationABSTRACT
Studies of the survival of weakly histoincompatible skin grafts in which the Langerhans' cells (LC)5 have been replaced with major histocompatibility complex (MHC)-compatible or incompatible LC, as well as studies of the fate of cultured endocrine allografts in MHC-compatible and incompatible mice and rats, indicate that allografts are only recognized as foreign if they possess donor macrophages (or cells of this family), or if antigen presenting cells MHC-compatible with the graft can be provided by the host.
Subject(s)
Major Histocompatibility Complex , Transplantation Immunology , Animals , Animals, Newborn/immunology , Chimera , Endocrine Glands/transplantation , Female , Graft Survival , H-Y Antigen/immunology , Heart Transplantation , Histocompatibility Antigens/immunology , Langerhans Cells/immunology , Male , Mice , Organ Culture Techniques , Rats , Sex Factors , Skin/immunology , Skin TransplantationSubject(s)
Leukocytes/immunology , Major Histocompatibility Complex , Parathyroid Glands/transplantation , Skin Transplantation , Animals , Female , Graft Survival , Immune Tolerance , Islets of Langerhans/immunology , Islets of Langerhans Transplantation , Mice , Mice, Inbred C57BL , Parathyroid Glands/immunology , Skin/immunologyABSTRACT
Studies on the survival of histocompatibility-Y antigen (H-Y)-incompatible and skin-specific antigen (Skn)-incompatible skin grafts in mice, as well as those concerned with the survival of cultured parathyroid allografts in rats, indicate that grafts provoke a strong immune response only if they include donor macrophages (or Langerhans cells) or if major histocompatibility complex-compatible macrophages are available to react with cells bearing the foreign antigens.
Subject(s)
Major Histocompatibility Complex , Transplantation Immunology , Animals , Animals, Newborn , Female , Immune Tolerance , Lymphocyte Transfusion , Male , Mice , Mice, Inbred Strains , Skin Transplantation , Transplantation, HomologousABSTRACT
Studies on the fate of Skn-incompatible grafts indicate that both the immune response to and the potency of these antigens are influenced by the MHC. Evidence is also presented that strains CBA, C3H, and A possess different Skn antigens.
