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1.
Heart failure affects innate immune memory.
Flemming, Alexandra.
Nat Rev Immunol ; 24(7): 456, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38862637

Subject(s)
Heart Failure , Immunity, Innate , Immunologic Memory , Immunity, Innate/immunology , Immunologic Memory/immunology , Humans , Animals , Heart Failure/immunology , Mice , Trained Immunity
2.
Engineered γδ T cells show promise in bone tumours.
Flemming, Alexandra.
Nat Rev Immunol ; 24(7): 458, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38862639

Subject(s)
Bone Neoplasms , Receptors, Antigen, T-Cell, gamma-delta , Humans , Receptors, Antigen, T-Cell, gamma-delta/immunology , Receptors, Antigen, T-Cell, gamma-delta/metabolism , Bone Neoplasms/immunology , Animals , Immunotherapy, Adoptive/methods , T-Lymphocytes/immunology , Mice
3.
How the brain regulates inflammation.
Flemming, Alexandra.
Nat Rev Immunol ; 24(6): 378, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38745003

Subject(s)
Brain , Inflammation , Animals , Humans , Brain/immunology , Brain/metabolism , Inflammation/immunology
4.
Connecting vitamin D, the microbiome and anticancer immunity.
Flemming, Alexandra.
Nat Rev Immunol ; 24(6): 378, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38745002

Subject(s)
Neoplasms , Vitamin D , Humans , Vitamin D/immunology , Vitamin D/metabolism , Neoplasms/immunology , Neoplasms/microbiology , Animals , Microbiota/immunology , Gastrointestinal Microbiome/immunology
5.
Time of day determines cancer immunotherapy response.
Flemming, Alexandra.
Nat Rev Immunol ; 24(6): 378, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38745004

Subject(s)
Immunotherapy , Neoplasms , Humans , Neoplasms/immunology , Neoplasms/therapy , Immunotherapy/methods , Time Factors , Animals
6.
Bacterial serotonin induces Treg cells in neonates.
Flemming, Alexandra.
Nat Rev Immunol ; 24(5): 306, 2024 May.
Article in English | MEDLINE | ID: mdl-38632490

Subject(s)
Serotonin , T-Lymphocytes, Regulatory , T-Lymphocytes, Regulatory/immunology , Serotonin/metabolism , Serotonin/immunology , Humans , Infant, Newborn , Animals , Mice
7.
Tumour cell consumption of taurine exhausts CD8+ T cells.
Flemming, Alexandra.
Nat Rev Immunol ; 24(5): 306, 2024 May.
Article in English | MEDLINE | ID: mdl-38632489

Subject(s)
CD8-Positive T-Lymphocytes , Taurine , CD8-Positive T-Lymphocytes/immunology , Humans , Animals , Neoplasms/immunology , Mice
8.
Neuronal TLR9 signalling crucial for memory formation.
Flemming, Alexandra.
Nat Rev Immunol ; 24(5): 306, 2024 May.
Article in English | MEDLINE | ID: mdl-38632491

Subject(s)
Immunologic Memory , Neurons , Signal Transduction , Toll-Like Receptor 9 , Toll-Like Receptor 9/metabolism , Toll-Like Receptor 9/immunology , Animals , Signal Transduction/immunology , Immunologic Memory/immunology , Neurons/metabolism , Neurons/immunology , Humans , Mice
9.
Regulation of innate-like activities of neonatal CD8+ T cells.
Flemming, Alexandra.
Nat Rev Immunol ; 24(4): 232, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38467805

Subject(s)
CD8-Positive T-Lymphocytes , Immunity, Innate , Infant, Newborn , Humans , Cell Differentiation
10.
CARD8 kills CD4+ T cells in response to HIV entry.
Flemming, Alexandra.
Nat Rev Immunol ; 24(4): 232, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38467803

Subject(s)
HIV Infections , HIV-1 , Humans , CD4-Positive T-Lymphocytes , HIV-1/physiology , Neoplasm Proteins , CARD Signaling Adaptor Proteins
11.
Why have T cell-inducing vaccines for HIV failed so far?
Flemming, Alexandra.
Nat Rev Immunol ; 24(2): 89, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38200271

Subject(s)
AIDS Vaccines , HIV Infections , Vaccines , Humans , CD8-Positive T-Lymphocytes , HIV Infections/prevention & control
12.
Sleep deprivation whips up cytokine storm.
Flemming, Alexandra.
Nat Rev Immunol ; 24(1): 2, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38082102

Subject(s)
Cytokine Release Syndrome , Sleep Deprivation , Humans , Cytokines
13.
Gut fungi have lasting effect on immune response to severe COVID-19.
Flemming, Alexandra.
Nat Rev Immunol ; 23(12): 786, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37938793

Subject(s)
COVID-19 , Gastrointestinal Microbiome , Humans , Fungi/physiology , Immunity
14.
Host IgM facilitates mating in Leishmania.
Flemming, Alexandra.
Nat Rev Immunol ; 23(12): 786, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37938794

Subject(s)
Leishmania , Humans , Immunoglobulin M , Host-Parasite Interactions
15.
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis.
Flemming, Alexandra.
Nat Rev Immunol ; 23(12): 786, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37938795

Subject(s)
Autoimmune Diseases of the Nervous System , Encephalitis , Hashimoto Disease , Humans , T-Lymphocytes , Receptors, N-Methyl-D-Aspartate , Autoimmune Diseases of the Nervous System/therapy , Autoantibodies
16.
The distinctive immune features of long COVID.
Flemming, Alexandra.
Nat Rev Immunol ; 23(11): 703, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37816952

Subject(s)
COVID-19 , Post-Acute COVID-19 Syndrome , Humans
17.
Combination of tumour-targeted TNF and chemotherapy shows promising results in glioblastoma.
Flemming, Alexandra.
Nat Rev Immunol ; 23(7): 413, 2023 07.
Article in English | MEDLINE | ID: mdl-37286815

Subject(s)
Glioblastoma , Humans , Glioblastoma/drug therapy
18.
Copper boosts pro-inflammatory state of macrophages.
Flemming, Alexandra.
Nat Rev Immunol ; 23(6): 344, 2023 06.
Article in English | MEDLINE | ID: mdl-37173540

Subject(s)
Copper , Macrophages , Humans , Cytokines
19.
Dectin-1 on colonic γδ T cells mediates vulnerability to psychosocial stress.
Flemming, Alexandra.
Nat Rev Immunol ; 23(5): 271, 2023 05.
Article in English | MEDLINE | ID: mdl-37024578

Subject(s)
Lectins, C-Type , Receptors, Antigen, T-Cell, gamma-delta , Humans , T-Lymphocytes , Stress, Psychological
20.
Fasting affects monocyte lifespan and migration.
Flemming, Alexandra.
Nat Rev Immunol ; 23(4): 203, 2023 04.
Article in English | MEDLINE | ID: mdl-36918664

Subject(s)
Longevity , Monocytes , Humans , Fasting , Cell Movement
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