[Dependence of the intensity of the immune response on the characteristics of the formation of a Salmonella typhi antigen depot on erythrocytes]. / Zavisimost' vysoty immunnogo otveta ot osobennostei formirovanniia depo antigenov Salmonella typhi na éritrotsitakh.

Experiments on inbred mice, opposite in the capacity of their erythrocytes for the sorption of S. typhi antigens, have revealed that the intensity of immune response to the antigens depends on the functional potency of immunocompetent cells and the conditions of their priming. The optimal manifestations of the conditions for lymphocyte priming depends on the character of the antigen fixation by erythrocytes and antigen supply from the depot into the blood stream.

[Changes in the sorption of the antigens of the causative agent of typhoid on erythrocytes in the dynamic immune response]. / Izmenenie sorbtsii antigenov vozbuditelia briushnogo tifa na éritrotsitakh v dinamike immunnogo otveta.

The study of the adsorption capacity of erythrocytes in 4 strains of mice was made. According to the results of the determination of the background capacity of erythrocytes, the strains of mice, opposite with respect to the sorption of S. typhi Vi- and O-antigens, were selected. After the immunization of these mice with the killed culture of S. typhi, the process of the sorption of the antigen on erythrocytes showed a characteristic kinetics. The course of immune response was characterized by specific changes in the adsorption capacity of erythrocytes in all strains of mice: the increase of this capacity on week 1 was followed by its sharp drop on weeks 3-4 and its subsequent restoration to the initial level by weeks 7-8. The non-specific stimulation of the host had no essential influence on the kinetics of the fixation of S. typhi antigens on erythrocytes. Experiments with the passive immunization of the animals revealed that different receptors take part in the process of the sorption of Vi-antigen on erythrocytes, some of these receptors being related to antibodies.

[Adsorption of Vi antigen on human erythrocytes]. / Adsorbtsiia Vi-antigena na eritrotsitakh cheloveka.

The accumulation of Vi-antigen in the human body was studied with the use of such characteristic as the specific adsorption capacity of red blood cells. This parameter was shown to depend on the phenotype in the ABO blood group system. In cases of typhoid fever an increase in the adsorption capacity of red blood cells was observed at the acute period of the disease. These changes were particularly manifest in patients belonging to groups O and A. The authors suggest that the adsorption of the antigen on red blood cells has a definite kinetics related to the dynamics of the infectious process.

[Genetic aspects of the effect of Vi antigen deposition in the human body. II. The relationship of ABO system phenotypic classification to erythrocyte sorption capacity]. / Geneticheskie aspekty éffekta deponirovaniia Vi-antigena v organizme cheloveka. Soobshchenie II. Sviaz' fenotipicheskoi prined-lezhnosti po sisteme ABO s sorbtsionnoi sposobnost'iu éritrotsitov.

The ability of erythrocytes to absorb Vi-antigen at optimal (Sopt) and minimal (Smin) sensitizing doses in 52 patients suffering from enteric fever and 61 healthy individuals was studied. Smin has been found to be independent of ABO phenotype of both ill and healthy individuals. At the same time Sopt is considerably reduced in patients having A blood group as compared to healthy individuals. Relationship between antigen binding rigidity with erythrocyte receptors and individual blood groups has been determined.

[Immunoglobulins and their specific activity in cholera]. / Immunoglobuliny i ikh spetsificheskaia aktivnost' pri zabolevanii kholeroi

The authors studied the quantitative content of nonspecific immunoglobulins and antibodies of the IgG-, IgA-, and IgM-classes to the O-antigen of the cholera vibrio. There proved to be no marked dynamics of the quantitative immunoglobulins indices of various classes established at periods from the 3rd and the 18th day from the beginning of the disease in persons who sustained cholera. In persons who sustained cholera in the nonendemic focus of the disease serum antibodies were represented chiefly by the IgM-antibodies. The formation of IgA-antibodies in the persons examined differed from the regularities detected for the IgG- and IgM-classes and were characterized by rapidity and short duration. No correlation was found between the immunoglobulin levels of various classes and the serum antibody levels in case of cholera affection.

[Genetic aspects of the effect of Vi-antigen deposition in the human body. I. Hereditary cause of the effect of Vi-antigen deposition on erythrocytes]. / Geneticheskie aspekty éffekta deponirovaniia Vi-antigens v organizme cheloveka. Soobshchenie I. Nasledstvennaia obuslovlennost' éffekta deponirovaniia Vi-antigena na éritrotsitakh.

Investigation of the minimal and the optimal capasity of the Vi-antigen sorption in erythrocytes was carried out in partners of 11 pairs of monozygotic and 8 pairs of dizygotic twins. It is shown that the capacity of erythrocytes to sorb Vi-antigen in minimal concentrations (Smin) is under relatively rigid genetic control (G = 0.84), while the capacity of its sorption in optimal doses (Sopt) is to a much greater extent subjected to paratypic effects (G = 0.40). It is assumed that Smin is controlled by the system of the "main" gene, while Sopt is determined multifactorially, which affords the possibilities of creating adequate conditions for the vaccination of a concrete individual.

[Differences in certain immunological indices among persons who have had cholera and among Vibrio carriers]. / Razlichiia v nekotorykh immunologicheskikh pokazateliakh u lits, perenesshikh kholeru, i vibriononositelei

Blood sera of persons, who sustained cholera of different degree of severity, and of vibrio-carriers, and also chromatographic fractions obtained in separation of the mentioned sera on DEAE-cellulose were investigated in the reaction of agglutination and the indirect hemagglutination test. Immunological response in the vibrio carriers was realized by the microglobulin, and in the convalescents--by the macroglobulin type. There was also revealed an association between the severity of the course of cholera and the prevalence in the blood serum of one or another type of specific antibodies: in severe forms of the disease the antibodies of the IgM-class were detected with the greatest frequency, and microglobulin antibodies--in vibrio carriers. The detected differences in the immunological status of those who sustained cholera and of vibrio-carriers could be used as an additional differential sign in the diagnosis of the mentioned conditions.