ABSTRACT
The Schizosaccharomyces pombe GTPase, Spg1 , activates the septation initiation network (SIN) protein kinase cascade to trigger septation. In the absence of functional Spg1 , cells fail cytokinesis and become multinucleate. In this study, we characterize a set of temperature-sensitive spg1 alleles isolated in the 1990s. We identify the mutations within each new and previously characterized allele, characterize the extent of relative growth defects, and assess their interaction with other SIN alleles.
ABSTRACT
Unhealthy weight gain and retention during pregnancy and postpartum is detrimental to mother and child. Although various barriers limit the capacity for perinatal health care providers (PHCPs) to offer healthy lifestyle counselling, they could guide women to appropriate online resources. This paper presents a project designed to provide online information to promote healthy lifestyles in the perinatal period. Focus groups or interviews were held with 116 perinatal women and 76 PHCPs to determine what online information perinatal women and PHCPs want, in what form, and how best it should be presented. The results indicated that women wanted smartphone applications (apps) linked to trustworthy websites containing short answers to everyday concerns; information on local support services; and personalised tools to assess their nutrition, fitness and weight. Suggestions for improvement in these lifestyle areas should be practical and tailored to the developmental stage of their child. PHCPs wanted evidence-based, practical information, presented in a simple, engaging, interactive form. The outcome was a clinically endorsed website and app that health professionals could recommend. Preliminary evaluation showed that 10.5% of pregnant women in Western Australia signed up to the app. Use of the app appeared to be equitable across urban and rural areas of low to middle socioeconomic status.
Subject(s)
Consumer Health Information/standards , Health Behavior , Medical Informatics Applications , Perinatal Care/standards , Pregnant Women , Access to Information , Cell Phone/instrumentation , Cell Phone/statistics & numerical data , Consumer Health Information/methods , Consumer Health Information/statistics & numerical data , Female , Focus Groups , Health Personnel , Humans , Internet/statistics & numerical data , Interviews as Topic , Needs Assessment , Obesity/prevention & control , Organizational Case Studies , Perinatal Care/methods , Pregnancy , Social Support , Western Australia , WorkforceABSTRACT
This is a follow-up study of 28 young people aged between 7 and 17 meeting the Oxford criteria for the diagnosis of chronic fatigue syndrome treated in a specialist paediatric/psychiatric service. Retrospective case note analysis revealed a wide range and duration of symptoms together with high levels of school absenteeism prior to the diagnosis. The mean follow-up interval after discharge from the specialist service was 3 years and although most of the young people regarded themselves as fully recovered by this time, improvement was variable and about one third were still experiencing disabling symptoms. The illness had impacted on the education or career plans of all the young people to some extent with 15 experiencing difficulty returning to school. This article highlights the need for early recognition and diagnosis of chronic fatigue syndrome in young people and the importance of continuing paediatric support to reduce symptom persistence in the sensitive recovery period. Maintaining school attendance by close liaison between health and education services both before and after diagnosis and treatment is also vital if long-term morbidity is to be reduced.
Subject(s)
Absenteeism , Fatigue Syndrome, Chronic/epidemiology , Adolescent , Child , Demography , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/therapy , Female , Follow-Up Studies , Humans , Male , Psychotherapy , Retrospective Studies , Schools , Severity of Illness Index , Students/statistics & numerical dataABSTRACT
OBJECTIVE: To review the challenge of providing integrated mental health services from a policy and health management perspective. CONCLUSIONS: The provision of integrated mental health services involving specialist mental health services, general practitioners, psychiatric disability and rehabilitation services and public community health services is a major challenge in the Australian health care context and is increasingly an expectation of the community. Government, Divisions of General Practice and public community health policy and many Government, State and local initiatives have attempted to address this challenge. However, much remains to be done, including culture change within services and professions and the development of technology to support integrated service provision.
