1.
Chem Commun (Camb)
; 58(57): 7912-7915, 2022 Jul 14.
Article
in English
| MEDLINE
| ID: mdl-35726903
ABSTRACT
Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance of administered multifunctional branched PEGylated nanomedicines. The temporal influence of pre-targeting on polymer interaction with tumour cells and tissue is explored using in vitro assays through to preclinical validation.
Subject(s)
Antibodies, Bispecific , Nanostructures , Neoplasms , Humans , Nanomedicine , Neoplasms/drug therapy , Polymers
2.
Chem Commun (Camb)
; 54(82): 11538-11541, 2018 Oct 11.
Article
in English
| MEDLINE
| ID: mdl-30182121
ABSTRACT
We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.