Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate Use.

Autism Spectrum Disorders comprise conditions that may affect cognitive development, motor skills, social interaction, communication, and behavior. This set of functional deficits often results in lack of independence for the diagnosed individuals, and severe distress for patients, families, and caregivers. There is a mounting body of evidence indicating the effectiveness of pure cannabidiol (CBD) and CBD-enriched Cannabis sativa extract (CE) for the treatment of autistic symptoms in refractory epilepsy patients. There is also increasing data support for the hypothesis that non-epileptic autism shares underlying etiological mechanisms with epilepsy. Here we report an observational study with a cohort of 18 autistic patients undergoing treatment with compassionate use of standardized CBD-enriched CE (with a CBD to THC ratio of 75/1). Among the 15 patients who adhered to the treatment (10 non-epileptic and five epileptic) only one patient showed lack of improvement in autistic symptoms. Due to adverse effects, three patients discontinued CE use before 1 month. After 6-9 months of treatment, most patients, including epileptic and non-epileptic, showed some level of improvement in more than one of the eight symptom categories evaluated: Attention Deficit/Hyperactivity Disorder; Behavioral Disorders; Motor Deficits; Autonomy Deficits; Communication and Social Interaction Deficits; Cognitive Deficits; Sleep Disorders and Seizures, with very infrequent and mild adverse effects. The strongest improvements were reported for Seizures, Attention Deficit/Hyperactivity Disorder, Sleep Disorders, and Communication and Social Interaction Deficits. This was especially true for the 10 non-epileptic patients, nine of which presented improvement equal to or above 30% in at least one of the eight categories, six presented improvement of 30% or more in at least two categories and four presented improvement equal to or above 30% in at least four symptom categories. Ten out of the 15 patients were using other medicines, and nine of these were able to keep the improvements even after reducing or withdrawing other medications. The results reported here are very promising and indicate that CBD-enriched CE may ameliorate multiple ASD symptoms even in non-epileptic patients, with substantial increase in life quality for both ASD patients and caretakers.

[Autonomy as a central criterion in the concept of health promotion]. / Autonomia como categoria central no conceito de promoção de saúde.

This article presents the central concepts of the multiple case study "Health Promotion in Primary Care" conducted by Nescon-UFMG in 2005. Teams of the Family Health Program developed twelve health promotion experiences in different Brazilian regions. After a conceptual revision and field research, health promotion was defined as the process of improving the health of people independently of any previous disease or injury, helping them to increase control over their health. We also concluded that an increased autonomy, understood as the capacity and possibility of the persons to choose, is the central category and criterion for defining health promotion practices.

Autonomia como categoria central no conceito de promoção de saúde / Autonomy as a central criterion in the concept of health promotion

Este artigo expõe os conceitos centrais do estudo de múltiplos casos: "Promoção de Saúde na Atenção Básica". O estudo foi conduzido pelo Nescon-UFMG em 2005 em doze experiências de promoção da saúde realizadas por equipes do Programa de Saúde da Família (PSF) em diversas regiões do Brasil. Após revisão teórica e pesquisa de campo, a definição de promoção da saúde adotada foi a atuação para a melhoria da saúde, anterior e independente a qualquer patologia ou agravo, ampliando-se o controle das pessoas sobre a própria saúde. Também concluímos que a ampliação da autonomia, vista como ampliação das capacidades e possibilidades de escolha das pessoas, é a categoria central e o critério definidor da atuação em promoção de saúde.

This article presents the central concepts of the multiple case study "Health Promotion in Primary Care" conducted by Nescon-UFMG in 2005. Teams of the Family Health Program developed twelve health promotion experiences in different Brazilian regions. After a conceptual revision and field research, health promotion was defined as the process of improving the health of people independently of any previous disease or injury, helping them to increase control over their health. We also concluded that an increased autonomy, understood as the capacity and possibility of the persons to choose, is the central category and criterion for defining health promotion practices.