ABSTRACT
PURPOSE OF INVESTIGATION: The purpose of the present study was to identify the clinical and pathologic features of ovarian cancers in patients who have a family history of breast or ovarian cancer but who do not have a mutation in the BRCA1 or BRCA2 gene. METHODS: 303 patients with ovarian cancer were reviewed for clinical features and for cancer family histories. After the exclusion of 51 patients known to carry BRCA1 or BRCA2 mutations, 24 patients with familial cancer were compared with 228 patients with non-familial cancer. RESULTS: Patients with familial cancer were more likely to have grade 2 tumors, Stage II disease and to present between ages 51 and 60 than were non-familial controls. Ten of 24 patients in the familial group presented between ages 51 and 60 with a grade 2 tumor compared to 3.0 expected (p = 0.001). CONCLUSIONS: Families of women who present with grade 2 ovarian cancer between the ages of 51 and 60 may have an unidentified ovarian cancer susceptibility gene.
Subject(s)
Genetic Predisposition to Disease , Ovarian Neoplasms/epidemiology , Ovarian Neoplasms/genetics , Adult , Case-Control Studies , Female , Genes, BRCA1 , Genes, BRCA2 , Humans , Middle Aged , Mutation , Neoplasm Staging , Ovarian Neoplasms/etiology , Ovarian Neoplasms/pathology , Poland/epidemiologyABSTRACT
The aim of this work was to compare the outcome of the questionnaire survey of low back pain with data on related sickness absenteeism. The questionnaire was responded by 585 (88.8%) employees. Of these number 288 (49.2%) respondents complained of low back pain. Sick leaves were given to 48 (16.7%) persons who had reported low back pains in the questionnaire and to 25 (8.4%) employees of 297 who had not reported the pain and also to 4 (5.4%) persons of 57 who had not responded to the questionnaire. Among those who had not complained of low back pain and were given sick leaves, mostly short ones, there were mainly men and blue collar workers. On the basis of our survey it seems that the analysis of sickness absenteeism due to low back pain does not completely reflect the prevalence of this disease, and that epidemiological studies of the prevalence should also take into consideration relevant sickness absenteeism.
