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1.
NPJ Prim Care Respir Med ; 30(1): 22, 2020 05 15.
Article in English | MEDLINE | ID: mdl-32415077

ABSTRACT

American and European societies' (ATS/ERS) criteria for spirometry are often not met in primary care. Yet, it is unknown if quality is sufficient for daily clinical use. We evaluated quality of spirometry in primary care based on clinical usefulness, meeting ATS/ERS criteria and agreement on diagnosis between general practitioners (GPs) and pulmonologists. GPs included ten consecutive spirometry tests and detailed history questionnaires of patients who underwent spirometry as part of usual care. GPs and two pulmonologists assessed the spirometry tests and questionnaires on clinical usefulness and formulated a diagnosis. In total, 149 participants covering 15 GPs were included. Low agreements were found on diagnosis between GPs and pulmonologists 1 (κ = 0.39) and 2 (κ = 0.44). GPs and pulmonologists rated >88% of the tests as clinically useful, although 13% met ATS/ERS criteria. This real-life study demonstrated that clinical usefulness of routine primary care spirometry tests was high, although agreement on diagnosis was low.


Subject(s)
Lung Diseases/diagnosis , Primary Health Care/methods , Quality of Health Care/standards , Spirometry/standards , Asthma/diagnosis , Asthma/physiopathology , Female , Humans , Lung Diseases/physiopathology , Male , Middle Aged , Observer Variation , Primary Health Care/standards , Pulmonary Disease, Chronic Obstructive/diagnosis , Pulmonary Disease, Chronic Obstructive/physiopathology , Pulmonologists/standards , Pulmonologists/statistics & numerical data , Quality of Health Care/statistics & numerical data , Spirometry/methods , Surveys and Questionnaires
2.
Eur J Clin Nutr ; 72(4): 557-563, 2018 04.
Article in English | MEDLINE | ID: mdl-29459789

ABSTRACT

BACKGROUND/OBJECTIVES: Human breast milk is generally regarded as the best nutrition for infants in their first months of life. Whether breastfeeding has a protective effect on food allergy is a point of debate and the subject of this study. SUBJECTS/METHODS: This retrospective study was conducted in 649 children who underwent a double-blind placebo-controlled food challenge (DBPCFC) as part of routine care in a tertiary care clinic. Food allergy was defined as having at least one positive DBPCFC to any food. The association between both "any" breastfeeding (yes/no) and its duration in months with food allergy was studied by logistic regression analysis with correction for confounding variables. RESULTS: The prevalence of food allergy was 58.9% (n = 382). Of all subjects, 75.8% (n = 492) was breastfed and 24.2% (n = 157) bottle-fed. There was no significant association between food allergy and breastfeeding versus bottle-feeding after correction for the confounding effect of increased breastfeeding by atopic parents and a history of asthma in the child (OR = 1.24, 95% CI = 0.85-1.79, p = 0.27). However, in breastfed children, every additional month of breastfeeding lowered the risk for food allergy by ~4% (OR = 0.96, 95% CI = 0.93-0.99, p = 0.02). No confounders were identified in this association. CONCLUSION: These results show for the first time that in children investigated for possible food allergy, every additional month of breastfeeding is associated with a lower risk of developing clinical food allergy as diagnosed by DBPCFC. However, overall, there was no association between the prevalence of food allergy and breastfeeding versus bottle-feeding in this tertiary care population.


Subject(s)
Breast Feeding/statistics & numerical data , Food Hypersensitivity/epidemiology , Adolescent , Adult , Child , Child, Preschool , Double-Blind Method , Female , Humans , Immunologic Tests , Infant , Male , Retrospective Studies , Young Adult
3.
Allergy ; 73(7): 1532-1540, 2018 Jul.
Article in English | MEDLINE | ID: mdl-29380392

ABSTRACT

BACKGROUND: There is currently considerable uncertainty regarding what the predictors of the severity of diagnostic or accidental food allergic reactions are, and to what extent the severity of such reactions can be predicted. OBJECTIVE: To identify predictors for the severity of diagnostic and accidental food allergic reactions and to quantify their impact. METHODS: The study population consisted of children with a double-blind, placebo-controlled food challenge (DBPCFC)-confirmed food allergy to milk, egg, peanut, cashew nut, and/or hazelnut. The data were analyzed using multiple linear regression analysis. Missing values were imputed using multiple imputation techniques. Two scoring systems were used to determine the severity of the reactions. RESULTS: A total of 734 children were included. Independent predictors for the severity of the DBPCFC reaction were age (B = 0.04, P = .001), skin prick test ratio (B = 0.30, P < .001), eliciting dose (B = -0.09, P < .001), level of specific immunoglobulin E (B = 0.15, P < .001), reaction time during the DBPCFC (B = -0.01, P = .004), and severity of accidental reaction (B = 0.08, P = .015). The total explained variance of this model was 23.5%, and the eliciting dose only contributed 4.4% to the model. Independent predictors for more severe accidental reactions with an explained variance of 7.3% were age (B = 0.03, P = .014), milk as causative food (B = 0.77, P < .001), cashew as causative food (B = 0.54, P < .001), history of atopic dermatitis (B = -0.47, P = .006), and severity of DBPCFC reaction (B = 0.12, P = .003). CONCLUSIONS: The severity of DBPCFCs and accidental reactions to food remains largely unpredictable. Clinicians should not use the eliciting dose obtained from a graded food challenge for the purposes of making risk-related management decisions.


Subject(s)
Allergens/immunology , Food Hypersensitivity/diagnosis , Food Hypersensitivity/immunology , Food/adverse effects , Adolescent , Child , Child, Preschool , Comorbidity , Female , Humans , Immunoglobulin E/blood , Immunoglobulin E/immunology , Infant , Male , Prognosis , Sensitivity and Specificity , Severity of Illness Index , Skin Tests
4.
Pediatr Allergy Immunol ; 28(3): 238-244, 2017 05.
Article in English | MEDLINE | ID: mdl-27992679

ABSTRACT

BACKGROUND: Successful treatment of anaphylaxis in the community relies on early and correct use of epinephrine auto-injectors (EAI). In the Netherlands, pharmacists supply EAIs to patients and have a crucial role in instructing patients in how and when to use EAI. However, there are currently no data in Europe on the quality of such instruction provided by pharmacists. Therefore, the aims of this study were to investigate the knowledge, attitudes, and beliefs regarding food allergy among pharmacists in the Netherlands and to investigate the quality of EAI instructions and demonstrations to patients by pharmacists. METHODS: Pharmacists were asked to complete an online questionnaire. Quality of instructions and demonstration accuracy were assessed in mystery guest visits to randomly selected pharmacies. For the statistical analysis, descriptive methods were used. RESULTS: In total, 25 of 115 questionnaires were completed. Only two (8%) respondents gave correct answers concerning the proper EAI demonstration. Twenty-one (84%) respondents thought that the provision of instructions was the responsibility of pharmacists. In total, ten pharmacies were included in simulated patient visits. Five of them (50%) demonstrated the EAI. None of them demonstrated the EAI use correctly. CONCLUSION: Food-allergic patients at high risk for anaphylaxis who receive their EAI from a community pharmacy are often not instructed on how to use an EAI or receive incorrect instructions. Pharmacists show considerable gaps in knowledge about food allergy and its management. These data suggest that opportunities exist to improve the quality of care provided by pharmacies to high-risk food-allergic patients.


Subject(s)
Anaphylaxis/drug therapy , Epinephrine/administration & dosage , Food Hypersensitivity/drug therapy , Health Knowledge, Attitudes, Practice , Patient Education as Topic/methods , Pharmacists/statistics & numerical data , Adult , Aged , Female , Humans , Male , Middle Aged , Netherlands , Self Administration , Surveys and Questionnaires
5.
Pediatr Allergy Immunol ; 27(8): 812-817, 2016 12.
Article in English | MEDLINE | ID: mdl-27495003

ABSTRACT

BACKGROUND: Previous studies showed that health-related quality of life (HRQL) significantly improved after the food challenge, with greater improvements in HRQL after a negative outcome than after a positive outcome. It is currently unknown whether this also occurs in patients undergoing DBPCFCs with cashew nut in the context of a clinical trial. METHODS: Quality of life was studied in children enrolled in a cashew nut study using Food Allergy Quality of Life Questionnaires (FAQLQs). Children, teenagers and parents of the children completed the questionnaires before the challenge test and 6 months after the DBPCFC with cashew nut. The difference in the change in HRQL between the children with a positive and negative DBPCFC outcome was studied by Mann-Whitney U-test. RESULTS: In total, 112 children (67 boys, median age of 9 years) were included. The children, teenagers and parents of the children completed 143 sets of questionnaires in total. There were no significant differences in baseline total and domain scores compared to the follow-up scores in the FAQLQ-CF, FAQLQ-TF and FAQLQ-PF. In children, the delta FAIM score in the negative DBPCFC tested group was significantly better than the delta FAIM score in the positive challenged group (p = 0.026). There were no significant differences in the changes in the scores of the FAQLQ-CF and FAQLQ-PF in the children with a positive challenge outcome, compared to the children with a negative challenge result. However, there was a significant difference in the change in score between the latter groups in the domain 'accidental exposure' of the FAQLQ-TF (p = 0.049). CONCLUSION: This study showed no difference in the change in HRQL scores after a DBPCFC with cashew nut in children participating in a clinical trial. The utility of HRQL as an outcome for clinical trials in food allergy may be limited if participant baseline HRQL is relatively unimpaired.


Subject(s)
Allergens/immunology , Nut Hypersensitivity/diagnosis , Quality of Life , Adolescent , Anacardium/immunology , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Immunization , Male , Parents , Surveys and Questionnaires
7.
Eur Ann Allergy Clin Immunol ; 48(3): 82-7, 2016 May.
Article in English | MEDLINE | ID: mdl-27152603

ABSTRACT

Food allergy is a health problem with significant negative impact in Quality of Life (QoL). We aimed to translate into Portuguese and culturally adapt to our population the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF). Cross-cultural translation was performed according to guidelines. Linguistic validation consisted in 3 steps: forward translation, backward translation and comprehensibility testing. A consensual version was obtained and tested in parents of food allergic children by cognitive debriefing. Twelve questionnaires were fulfilled, all completed in ≤ 15 min. No comments, doubts or suggestions were posed, except for 2 parents regarding a question about the number of food their children had to avoid. Two gave special positive feedback about the utility of FAQLQ-PF. Changes have been included after this pre-test in accordance to doubts and suggestions of participants, and the Portuguese version is now able to be used in clinics and research.


Subject(s)
Food Hypersensitivity , Humans , Parents , Quality of Life , Surveys and Questionnaires
8.
Allergy ; 71(11): 1585-1593, 2016 11.
Article in English | MEDLINE | ID: mdl-27089859

ABSTRACT

BACKGROUND: Presently, no validated data exist on symptom severity and disease-specific quality-of-life (QoL) for patients with mastocytosis. Simultaneously, clinical trials and drug application processes increasingly mandate reporting patients' perspectives on symptoms and QoL. We report on the development and validation of the mastocytosis quality-of-life questionnaire (MQLQ) and the mastocytosis symptom assessment form (MSAF). METHODS: Both outcome measures were developed in a standardized stepwise method, starting with the identification of items in focus groups (n = 12), item reduction and subsequent cross-sectional validation in a 63% female cohort of 164 adult patients with indolent systemic mastocytosis. RESULTS: The MSAF reveals that fatigue is the severest mastocytosis symptom while the MQLQ indicates that fear of anaphylaxis mostly impacts QoL. Cross-sectional validity was assessed by correlating both individual domains and the total scores of the MQLQ and MSAF with independent measures of mastocytosis. The total scores of both the MQLQ (P < 0.001; Spearman's r: 0.568) and the MSAF (P < 0.001; Spearman's r: 0.559) correlated significantly with the consensus on physician-scored mediator symptoms. The MQLQ domains displayed a high internal consistency (Cronbach's alpha: 0.841-0.958) and the domains 'bones', 'skin symptoms' and 'anaphylaxis' differed significantly between patients with and without osteoporosis, urticaria pigmentosa or anaphylaxis, respectively (P < 0.001). CONCLUSIONS: The MQLQ is the first disease-specific QoL questionnaire for mastocytosis and is complemented by the MSAF, a short and convenient symptom scoring form. Both patient-reported outcome measures are valid, reliable and discriminate between patients with different disease characteristics, making them useful instruments for clinical research.


Subject(s)
Mastocytosis, Systemic/diagnosis , Mastocytosis, Systemic/epidemiology , Quality of Life , Cross-Sectional Studies , Female , Humans , Male , Self Report , Severity of Illness Index , Surveys and Questionnaires , Symptom Assessment
9.
Allergy ; 71(7): 1069-73, 2016 07.
Article in English | MEDLINE | ID: mdl-27121602

ABSTRACT

The time during which children are observed following a double-blind, placebo-controlled food challenge (DBPCFC) varies in clinical practice. There are little data on late reactions (LRs) following DBPCFCs. Therefore, we determined the prevalence, severity and clinical characteristics of late reactions in food-allergic children and adolescents after DBPCFC, and ascertained which factors are associated with, and may predict, LRs. Logistic regression analyses were performed to investigate which factors were associated with LRs and to develop the association and prediction models. A total of 1142 children underwent DBPCFCs (child-test combinations). Of these 1142 child-test combinations, 400 reported LRs following the DBPCFC. LRs in food-allergic children after DBPCFC are poorly predictable and are generally not severe. All LRs, including those on the placebo day, are more frequently reported in younger children. Children who do not experience severe immediate reactions may be safely discharged home 2 h after a DBPCFC.


Subject(s)
Allergens/immunology , Food Hypersensitivity/diagnosis , Food Hypersensitivity/immunology , Food/adverse effects , Allergens/administration & dosage , Child , Child, Preschool , Comorbidity , Female , Food Hypersensitivity/epidemiology , Humans , Immunoglobulin E/blood , Immunoglobulin E/immunology , Infant , Male , Prevalence , Prognosis , Severity of Illness Index , Symptom Assessment , Time Factors
10.
Pediatr Allergy Immunol ; 27(1): 28-34, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26269417

ABSTRACT

BACKGROUND: Food-allergic patients at high risk of potential fatal anaphylaxis should carry an epinephrine auto-injector (EAI) at all times. This treatment may be perceived as burdensome and this may affect compliance and health-related quality of life (HRQL). The aims of the study were (1) to determine the burden of treatment (BoT) of an EAI, (2) to examine the relationship between this burden and compliance, and (3) to analyze which factors contribute to the BoT of the EAI as perceived by food-allergic adolescents and their parents. METHODS: Dutch food-allergic adolescents prescribed an EAI, and their parents completed a questionnaire package (n = 55). Relationships between BoT and HRQL, illness severity and perception, and anxiety measures were investigated. RESULTS: Food-allergic adolescents and their parents were (extremely) positive about the EAI (54.5%; 72.7%, respectively) (=low BoT). The BoT measure showed a significantly greater burden in food-allergic adolescents prescribed an EAI who reported not carrying the EAI at all times than adolescents who reported they did. The BoT scores of both adolescents and their parents were not associated with HRQL, illness severity and perception, or trait anxiety. CONCLUSIONS: The majority of food-allergic adolescents and their parents were positive about the EAI (=low BoT). However, the BoT was significantly associated with self-reported compliance with carrying the EAI. The BoT was higher in food-allergic adolescents prescribed an EAI who reported not carrying the EAI at all times. The BoT measure seems to be a useful tool to study compliance with carrying an EAI. The BoT of an EAI is not associated with HRQL. The BoT measures a distinct concept related to compliance behavior.


Subject(s)
Adolescent Behavior , Anti-Allergic Agents/administration & dosage , Cost of Illness , Epinephrine/administration & dosage , Food Hypersensitivity/drug therapy , Health Knowledge, Attitudes, Practice , Medication Adherence , Self Administration , Adolescent , Age Factors , Anxiety/psychology , Female , Food Hypersensitivity/diagnosis , Food Hypersensitivity/psychology , Humans , Injections , Male , Middle Aged , Netherlands , Parents/psychology , Perception , Quality of Life , Severity of Illness Index , Surveys and Questionnaires , Treatment Outcome
11.
Article in English | MEDLINE | ID: mdl-26472961

ABSTRACT

BACKGROUND: The knowledge of general practitioner(s) (GPs) regarding food allergy and anaphylaxis and practices in the prescription of epinephrine auto-injector(s) (EAIs) among GPs has previously only been studied using questionnaires and hypothetical cases. Therefore, there are currently no data as to whether or not GPs prescribe EAIs to high risk food-allergic patients presenting to primary care practices. The aim of this study was therefore to describe and evaluate practice in EAI prescription by GPs to food-allergic patients in The Netherlands. METHODS: Patients aged 12-23 years who consulted their GP for allergic symptoms were identified in a primary care database. Patients were classified as probably or unlikely to be food-allergic. A risk factor assessment was done to identify probably food-allergic patients at high risk for anaphylaxis to assess the need for an EAI. RESULTS: One hundred forty-eight out of 1015 patients consulted their GP for allergic symptoms due to food. Eighty patients were excluded from analysis because of incomplete records. Thirty-four patients were classified as probably food-allergic. Twenty-seven of them were considered high risk patients and candidates for an EAI. Importantly, only 10 of them had actually been prescribed an EAI by their GP. CONCLUSIONS: This study shows that high risk food-allergic patients that visit their GPs are often not prescribed an EAI. Thus, previously identified low rates of EAI ownership may be partly due to GPs not prescribing this medication to patients for whom it would be appropriate to do so. These data suggest that there is a need for improvement of the quality of care for high risk food-allergic patients in primary care.

12.
Article in English | MEDLINE | ID: mdl-26310041

ABSTRACT

INTRODUCTION: Specific food allergy quality of life questionnaires have been developed within the context of the EuroPrevall project. We aimed to adapt and validate the Food Allergy Quality of Life Questionnaire-Adult Form (FAQLQ-AF) in the Spanish language. METHODS: The original English questionnaire was translated and culturally adapted into Spanish following World Health Organization guidelines. The final Spanish version of the FAQLQ-AF (S-FAQLQ-AF) was approved by the original authors. Consecutive patients ( 18 years old) who fulfilled the following criteria were recruited: 1) diagnosis of food allergy defined as immediate allergic symptoms and a positive prick test or IgE against the culprit food(s) and 2) physician-assessed ability to complete the questionnaires. Patients completed the S-FAQLQ-AF and a Spanish version of the SF-12 questionnaire. Reliability was assessed 10 to 14 days after completion of the first questionnaire. RESULTS: Eighty-two consecutive outpatients were recruited and cross-sectional validity was.assessed based on the correlation between the S-FAQLQ-AF and the Food Allergy Independent Measure (FAIM) in this population (rho = 0.83, P < .0001). The S-FAQLQ-AF showed excellent internal consistency (Cronbach α, 0.95). S-FAQLQ-AF domains also had excellent internal consistency: α = 0.93 for allergen avoidance-dietary restrictions; α = 0.83 for emotional impact; α = 0.85 for risk of accidental exposure, and α = 0.66 for food allergy related health. Limited correlation was found between the S-FAQLQ-AF and the SF-12. CONCLUSION: The S-FAQLQ-AF is a valid, short, easy-to-use, and reliable instrument that discriminates between patients with different atopic phenotypes and is suitable for assessing the impact of IgE-mediated food allergy on patient quality of life.


Subject(s)
Food Hypersensitivity/psychology , Quality of Life , Surveys and Questionnaires , Adult , Cross-Sectional Studies , Humans , Language , Young Adult
13.
Allergy ; 70(11): 1406-12, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26138410

ABSTRACT

BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual analogue scale (VAS). RESULTS: Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges with these downregulated apple lines produced significantly less intense maximal symptoms to the first dose (Vmax1) than with Elstar (Vmax1 Elstar 3.0 mm vs 0.0 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043), as well as significantly less intense mean symptoms per dose (meanV/d) than with Elstar (meanV/d Elstar 2.2 mm vs 0.2 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043). Only one subject (5%) remained symptom-free when challenged with the Elstar apple, whereas 43% did so with e-DR1 and 63% with e-DR2. CONCLUSION: These data show that mRNA silencing of Mal d 1 results in a marked reduction of Mal d 1 gene expression in the fruit and reduction of symptoms when these apples are ingested by allergic subjects. Approximately half of the subjects developed no symptoms whatsoever, and virtually all subjects wished to consume the apple again in the future.


Subject(s)
Antigens, Plant/genetics , Antigens, Plant/immunology , Food Hypersensitivity/immunology , Gene Silencing , Malus/adverse effects , Malus/genetics , Plant Proteins/genetics , Plant Proteins/immunology , Adult , Down-Regulation , Female , Food Hypersensitivity/diagnosis , Food Hypersensitivity/prevention & control , Gene Expression , Humans , Male , Plants, Genetically Modified , Young Adult
14.
Chem Immunol Allergy ; 101: 235-52, 2015.
Article in English | MEDLINE | ID: mdl-26022884

ABSTRACT

The majority of research on food allergy has been bio-medical in orientation, focusing on issues such as the molecular structure of allergens, or aimed at methods of diagnosis. In the last decade, there has been a growing interest in the development of questionnaires that measure the impact of food allergy on health-related quality of life (HRQL). These studies have provided insight into the everyday burden of living with food allergy and have suggested ways that HRQL can be improved. The EuroPrevall project (europrevall@bbsrc.ac.uk) has given great impetus to research in the area of HRQL. In addition to clinical research on the prevalence, mechanisms and causes of food allergy, research output in the area of psycho-social impact has included HRQL measures for all age groups and examination of the socio-economic impact of food allergy. In this chapter, we review the literature on the impact of food allergy on children, teens and their parents; the majority of this data was generated over the life of the EuroPrevall project. We then examine both quantitative and qualitative research findings to provide an in-depth picture of the impact of food allergy on the concerns and everyday lives of children, teens, adults and parents. Research on factors that are related to and impact HRQL is also discussed. There is a strong emphasis throughout the chapter on developmental considerations of food allergy, spanning from infants to adults. We conclude by discussing methodological issues in relation to the measurement of HRQL in relation to food allergy. We offer some recommendations for future research and practice on HRQL so that HRQL measures can reach their full potential in research, practice and policy, with the help of the findings in this review. Overall, the findings suggest that food allergy has a strong impact on HRQL in terms of social, dietary, and psychological factors. 'Rules' and restrictions ostensibly apply to food, but because food is such an integral part of everyday life, these restrictions extend far beyond 'mealtimes'. Therefore, social events are experienced differently and have a different meaning for those living with food allergy, giving rise to feelings of exclusion and difference when compared to those without allergy. Children, teens, and parents need to cope with normal developmental changes as well as with the food allergy, placing them under increased psycho-social stress and leading to adverse effects on HRQL and coping. To address and attempt to alleviate such stressors, both quantitative and qualitative research suggests that targeting uncertainty should be a major goal for health professionals working with children, teens and families with a food allergy. Remarkable similarities in response to food allergy across countries suggest that policies and programmes that address quality of life issues may be relevant to many different populations. An in-depth understanding of the relationship between a diagnosis of food allergy and HRQL, as well as the factors that impact it, will ultimately lead to the promotion of earlier, more effective preventive strategies and interventions that are focused on maximising optimal health development and quality of life.


Subject(s)
Food Hypersensitivity/psychology , Quality of Life , Adolescent , Adult , Child , Humans , Parents/psychology , Stress, Psychological , Surveys and Questionnaires , Young Adult
15.
Allergy ; 70(4): 461-4, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25620092

ABSTRACT

The aim of this study was to assess the genetic association of Filaggrin loss-of-function (FLG LOF) genetic variants with food allergy, and to investigate the added value of this test in diagnosing food allergy. Clinical reactivity to foods was diagnosed by the gold standard, the double-blind, placebo-controlled food challenge. Of 155 children, 33 (21.3%) children had at least one FLG LOF variant, and of these, 29 (87.9%) were clinically reactive to at least one food, compared to 73 of 122 children (59.8%) carrying wild-type alleles. The odds ratio for having at least one FLG LOF variant and clinical reactivity to at least one food was 4.9 (CI = 1.6-14.7, P = 0.005), corresponding to a relative risk of 1.5, compared to carriers of wild-type alleles. Prediction of food allergy improved when FLG LOF variants were included in the model. Therefore, genetic markers may be useful as an addition to clinical assessment in the diagnosis of food allergy.


Subject(s)
Food Hypersensitivity/genetics , Food Hypersensitivity/immunology , Genetic Association Studies , Genetic Predisposition to Disease , Genetic Variation , Intermediate Filament Proteins/genetics , Alleles , Child , Child, Preschool , Female , Filaggrin Proteins , Food Hypersensitivity/diagnosis , Food Hypersensitivity/epidemiology , Gene Frequency , Genotype , Humans , Immunoglobulin E/blood , Immunoglobulin E/immunology , Male , Mutation , Odds Ratio , Prevalence , ROC Curve
16.
Allergy ; 70(6): 616-24, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25627424

ABSTRACT

BACKGROUND: Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may contribute to HRQL in food-allergic patients. Therefore, the aim of this study was to identify factors which may predict HRQL of food-allergic patients and also to investigate the specific impact of having experienced anaphylaxis and being prescribed an EAI on HRQL. METHODS: A total of 648 European food-allergic patients (404 adults, 244 children) completed an age-specific questionnaire package including descriptive questions. Multivariable regression analyses were performed to develop models for predicting HRQL of these patients. RESULTS: For adults, the prediction model accounted for 62% of the variance in HRQL and included perceived disease severity, type of symptoms, having a fish or milk allergy, and gender. For children, the prediction model accounted for 28% of the variance in HRQL and included perceived disease severity, having a peanut or soy allergy, and country of origin. For both adults and children, neither experiencing anaphylaxis nor being prescribed an epinephrine auto-injector (EAI) contributed to impairment of HRQL. CONCLUSIONS: In this study, food allergy-related HRQL may be predicted to a greater extent in adults than in children. Allergy to certain foods may cause greater HRQL impairment than others. Country of origin may affect HRQL, at least in children. Experiencing anaphylaxis or being prescribed an EAI has no impact on HRQL in either adults or children.


Subject(s)
Food Hypersensitivity/psychology , Health Status , Quality of Life , Adolescent , Adult , Anaphylaxis/drug therapy , Anaphylaxis/etiology , Child , Epinephrine/therapeutic use , Europe , Female , Food Hypersensitivity/complications , Food Hypersensitivity/drug therapy , France , Greece , Humans , Iceland , Ireland , Italy , Linear Models , Male , Middle Aged , Multivariate Analysis , Netherlands , Poland , Risk Factors , Severity of Illness Index , Spain , Surveys and Questionnaires , Sympathomimetics/therapeutic use , Young Adult
17.
J. investig. allergol. clin. immunol ; 25(4): 270-275, 2015. tab
Article in English | IBECS | ID: ibc-138422

ABSTRACT

Introducción: Se evalúa el impacto de la alergia alimentaria sobre la calidad de vida, mediante cuestionarios específicos integrado en el proyecto EuroPrevall. Validar y adaptar a lengua castellana el cuestionario FAQLQ-AF. Material y métodos: La traducción y adaptación cultural del cuestionario original se realizó siguiendo recomendaciones de la OMS. Los autores del cuestionario original aceptaron la versión en lengua castellana del FAQLQ-AF (S-FAQLQ-AF). Los pacientes fueron incluidos siguiendo los siguientes criterios: (1) Síntomas alérgicos tras ingesta de un alimento y prick test positivos o IgE frente al alimento implicado, (2) Un médico evaluó la capacidad de los pacientes para completar los cuestionarios (S-FAQLQ-AF y el genérico SF-12). Para explorar la fiabilidad de las respuestas entre 10 y 14 días después de rellenar el primer cuestionario, los pacientes rellenaban de nuevo el S-FAQLQ-AF con preguntas en distinto orden. Resultados: Ochenta y dos pacientes (≥18 años) fueron incluidos. La validez de constructo fue evaluada a partir de la correlación entre el S-FAQLQ-AF y el FAIM (Medida Independiente de la Alergia a Alimentos (rho =0.83, p<.0001). El cuestionario S-FAQLQ-AF (Cronbach-alpha =0.95) y sus diferentes dominios mostraron excelente consistencia interna: Evitación de alérgenos (alpha=0.93); impacto emocional (alpha=0.83), riesgo de exposición accidental (alpha=0.85) y salud relacionada con alergia alimentaria (alpha=0.66). No se halló correlación entre el S-FAQLQ-AF y el cuestionario SF-12. Conclusión: La versión Española del cuestionario de adultos FAQLQ-AF es una herramienta válida, fiable, fácil de usar, rápida de completar y sensible al cambio, discriminando pacientes con diferentes fenotipos atópicos, para evaluar el impacto de la alergia alimentaria en la calidad de vida (AU)


Introduction: Specific food allergy quality of life questionnaires have been developed within the context of the EuroPrevall project. We aimed to adapt and validate the Food Allergy Quality of Life Questionnaire-Adult Form (FAQLQ-AF) in the Spanish language. Methods: The original English questionnaire was translated and culturally adapted into Spanish following World Health Organization guidelines. The final Spanish version of the FAQLQ-AF (S-FAQLQ-AF) was approved by the original authors. Consecutive patients (≥18 years old) who fulfilled the following criteria were recruited: 1) diagnosis of food allergy defined as immediate allergic symptoms and a positive prick test or IgE against the culprit food(s) and 2) physician-assessed ability to complete the questionnaires. Patients completed the S-FAQLQ-AF and a Spanish version of the SF-12 questionnaire. Reliability was assessed 10 to 14 days after completion of the first questionnaire. Results: Eighty-two consecutive outpatients were recruited and cross-sectional validity was assessed based on the correlation between the S-FAQLQ-AF and the Food Allergy Independent Measure (FAIM) in this population (rho=0.83, P<.0001). The S-FAQLQ-AF showed excellent internal consistency (Cronbach alpha, 0.95). S-FAQLQ-AF domains also had excellent internal consistency: alpha=0.93 for allergen avoidance-dietary restrictions; alpha=0.83 for emotional impact; alpha=0.85 for risk of accidental exposure, and alpha=0.66 for food allergy related health. Limited correlation was found between the S-FAQLQ-AF and the SF-12. Conclusion: The S-FAQLQ-AF is a valid, short, easy-to-use, and reliable instrument that discriminates between patients with different atopic phenotypes and is suitable for assessing the impact of IgE-mediated food allergy on patient quality of life (AU)


Subject(s)
Humans , Male , Food Hypersensitivity/epidemiology , Skin Tests , In Vitro Techniques , Hypersensitivity/etiology , Immunization , Pollen/immunology , Food Hypersensitivity/immunology , Immunoassay , Retrospective Studies , Hypersensitivity, Immediate , 28599 , Surveys and Questionnaires
18.
Allergy ; 69(7): 834-44, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24836207

ABSTRACT

This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future treatments, as well as estimating the general burden of food allergy. The aim of this systematic review was therefore to identify which disease-specific, validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy. From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments available in a wider range of European languages.


Subject(s)
Food Hypersensitivity/complications , Food Hypersensitivity/psychology , Psychometrics/methods , Quality of Life , Surveys and Questionnaires , Adolescent , Adult , Child , Female , Humans , Immunoglobulin E , Male
19.
Allergy ; 69(7): 845-53, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24785644

ABSTRACT

Instruments have been developed and validated for the measurement of health-related quality of life in patients with food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group. It draws on a systematic review of the literature on quality of life instruments for food allergy and the Appraisal of Guidelines for Research & Evaluation (AGREE II) guideline development process. Guidance is provided on the use of such instruments in research, and the current limitations of their use in clinical practice are described. Gaps in current knowledge as well as areas of future interest are also discussed. This document is relevant to healthcare workers dealing with food-allergic patients, scientists engaging in food allergy research and policy makers involved in regulatory aspects concerning food allergy and safety.


Subject(s)
Food Hypersensitivity/complications , Food Hypersensitivity/psychology , Quality of Life , Surveys and Questionnaires , Humans
20.
Clin Exp Allergy ; 43(9): 1067-70, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23957342

ABSTRACT

BACKGROUND: Diagnostic and accidental food allergic reactions may be modified by the matrix containing the allergenic food. Previous studies of double-blind, placebo-controlled food challenges (DBPCFCs) with peanut found an effect of the fat content of the challenge matrix on the severity of the challenge reactions. OBJECTIVE: The aim of this study was to examine whether the fat content of the food matrix is related to eliciting dose and reaction severity in DBPCFCs with heated hen's egg. METHODS: Sensitized egg allergic children (n = 59) undergoing DBPCFCs with egg as a routine diagnostic procedure in our tertiary care centre were evaluated retrospectively. Three different recipes were used for the food matrix: vanilla pudding, pancake and minced meat, containing 22.8%, 31.9% and 52.7% fat (weighted average), respectively. The eliciting dose (i.e. the highest cumulative dose to which the child reacted) was analyzed by Kaplan-Meier log-rank statistic and by Cox regression. Reaction severity was quantified by using an index (range 1-12) and was analysed by multiple linear regression analysis. RESULTS: The overall influence of type of recipe on eliciting dose was not significant (P = 0.12). The rate of response to minced meat (with the highest fat content) was not significantly different from pudding [HR = 0.61 (0.26-1.45, P = 0.26) or pancake (HR = 1.41 (0.50-3.99), P = 0.52] after adjustment for confounders. The type of recipe did not influence the severity of the challenge reaction. The severity of the challenge reaction for minced meat compared to pudding and pancake was 1.06 (0.52-2.16), P = 0.87 and 0.81 (0.32-2.01), P = 0.64, respectively, after correction for confounders. CONCLUSION AND CLINICAL RELEVANCE: In contrast to similar research with peanut, no significant influence of the fat content of the matrix was found on the eliciting dose or severity of the reaction in 59 DBPCFCs with hen's egg. Matrix fat content differences comparable to those reported here may not be an important co-determinant of reaction severity for all allergenic foods.


Subject(s)
Allergens/immunology , Dietary Fats/adverse effects , Food Hypersensitivity/diagnosis , Food , Child, Preschool , Dose-Response Relationship, Immunologic , Eggs/adverse effects , Female , Humans , Infant , Male , Retrospective Studies , Severity of Illness Index
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