ABSTRACT
BACKGROUND: The present study attempted to provide information regarding non-muscle myosin II (MII) isoforms immunoreactivity in patients with head and neck squamous cell carcinoma (HNSCC) and analysis of the patients' clinical status after 5 years of monitoring. MATERIAL AND METHODS: A semiquantitative analysis of the immunoreactivity of the MII isoforms was performed in 54 surgical specimens and its correlation with clinical and pathological variables and prognosis was verified. Data were analyzed using chi-square, Mann-Whitney and Kruskal-Wallis tests. To evaluate the survival over the total monitoring time and any connection with the proteins studied, the Kaplan-Meier analysis was used. P values ≤0.05 were considered statistically significant. RESULTS: In the advanced stages of pathological tumor-node-metastasis, the expression of MIIB in adjacent non-neoplastic epithelial tissues tended to increase (p = 0.057). In tumoral zones there was an association of high expression among the three isoforms (MIIA/MIIB p=0,001, MIIB/MIIC p=0,006 and MIIA/MIIC p=0,012). Negative clinical evolution in patients was directly correlated to increased MIIC expression in the tumoral zone of invasion in HNSCC (p = 0.017). Based on clinical evolution after the monitoring period, patients with tumors expressing MIIC had poorer prognoses (p = 0.048). CONCLUSIONS: The present study suggests that MIIB expression in non-neoplastic adjacent epithelial tissues may indicate a potential for regional metastasis and that MIIC expression in the tumoral zone of invasion is predictive of negative evolution of the disease.
Subject(s)
Carcinoma, Squamous Cell , Head and Neck Neoplasms , Squamous Cell Carcinoma of Head and Neck , Biomarkers, Tumor , Humans , Myosin Type II , PrognosisABSTRACT
A taquicardia ventricular, geralmente, é consequência de anormalidades cardíacas. Aquelas cuja etiopatogenia näo pode ser definida pelos métodos diagnósticos atuais, Säo classificadas como idiopáticas. Gallavardin foi o primeiro, em 1922, a descrever a presença de taquicardias ventriculares, em pacientes jovens, sem cardiopatia aparente. Dentre as taquicardias ventriculares, este de de taquiarritmia tem incidência maior do que a esperada, podendo chegar a 10 por cento. O pequeno registro de ocorrênas deve-se a pouco frequente sintomatologia e ao insuficiente conhecimento médico deste distúrbio do ritmo cardíaco. O advento de métodos complementares de diagnóstico mais sofisticados permitiu melhor compreensäo destas arritmias, de seus mecanismos de produçäo, dos locais de origem e de seus fatores desencadeantes.
