Serum integrin-linked kinase (sILK) concentration and survival in non-small cell lung cancer: a pilot study

BACKGROUND: Integrin-linked kinase (ILK) is an intracellular signaling protein critically involved in cellular growth and motility. In non-small cell lung cancer (NSCLC), increased ILK expression has been associated with decreased recurrence-free and overall survival. Recently, ILK has also been detected in the serum of NSCLC patients. OBJECTIVE: To assess the prognostic impact of preoperative serum ILK (sILK) concentration on overall survival in surgically amenable NSCLC. PATIENTS AND METHODS: Preoperative sILK was quantified by ELISA in 50 newly diagnosed NSCLC patients. After surgery, patients were followed-up for a median interval of 2.5 years. RESULTS: Serum ILK concentrations ranged from 0 to 2.44 ng/ml. Mean sILK was around 2.3 times higher in the 16 patients who died as compared to the 34 patients who survived (1.04 vs. 0.45 ng/ml, p = 0.001). In univariate time-to-event analysis, increased sILK was associated with adverse survival [Hazard ratio (HR): 4.03, 95 % CI: 2.00-8.13, p < 0.001]. This association prevailed after multivariable adjustment for several clinical, demographic, and laboratory parameters (HR: 3.85, 95 % CI: 1.53-9.72, p = 0.004). CONCLUSIONS: Serum ILK shows potential as a novel strong and independent prognostic marker for postoperative survival in surgically amenable NSCLC (AU)

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Identificación de componentes del síndrome metabólico en pacientes mexicanos hospitalizados por síndrome isquémico coronario agudo: una herramienta para la prevención / Identification of components of metabolic syndrome in mexican patients hospitalized for acute ischemic coronary syndrome: A tool for prevention

Determinar la prevalencia de síndrome metabólico (SM) y sus componentes en pacientes con síndrome isquémico coronario agudo (SICA) en un hospital de tercer nivel. Métodos Participaron 65 pacientes que ingresaron a la unidad de cuidados intensivos coronarios con infarto agudo del miocardio o angina inestable. Se diagnóstico SM en base en los criterios del Adult Treatment Pannel (ATP-III). Resultados La prevalencia total de SM fue 84,6% (IC 95%:75,6 a 93,6), se presento más en mujeres, en personas con obesidad según índice de masa corporal (IMC) y con antecedentes familiares de diabetes y dislipidemia. Los fenotipos de predicción de SM fueron: IMC (OR=2,12, IC95%: 1,24, 3,17) y antecedentes personales de dislipidemia (OR=.026, IC95%: .003, .587).Conclusiones La prevalencia del SM en SICA es más elevada que la informada para otras poblaciones, hecho que resulta alarmante si este riesgo se mantiene en la población mexicana (AU)

Objective To determine the prevalence of metabolic syndrome (MS) and its risk factors in patients with Acute Ischemic Coronary Syndrome (AICS) in a tertiary hospital. Methods A total of 65 patients admitted to Cardiac Intensive Care Unit with myocardial infarction or unstable angina participated. MS was diagnosed in accordance to the Adult Treatment Panel III (ATPIII) criteria. Results The total prevalence of MS was 84.6% (95% CI: 75.6 to 93.6). MS was more frequent in women, persons with obesity according to the body mass index (BMI), family background diabetes, and dyslipidemia. Phenotype predictors of MS were: BMI (OR=2.12, 95% CI: 1.24, 3.17) and familiar history of dyslipidemia (OR=0.026, 95% CI: 0.003, 0.587).Conclusions The prevalence of MS with AICS is higher than that reported in other populations. This fact is alarming if this risk is maintained in the Mexican population(AU)