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1.
J Chem Neuroanat ; 132: 102316, 2023 10.
Article in English | MEDLINE | ID: mdl-37481172

ABSTRACT

Schizophrenia is a neurodevelopmental disorder characterized by a loss of dendritic spines in the medial prefrontal cortex (mPFC). Multiple subclinical and clinical studies have evidenced the ability of antipsychotics to improve neuroplasticity. In this study, it was evaluated the effect of the atypical antipsychotic aripiprazole (ARI) on the behavioral and mPFC neuronal disturbances of rats with neonatal ventral hippocampus lesion (nVHL), which is a heuristic developmental model relevant to the study of schizophrenia. ARI attenuated open field hyperlocomotion in the rats with nVHL. Also, ARI ameliorated structural neuroplasticity disturbances of the mPFC layer 3 pyramidal cells, but not in the layer 5 neurons. These effects can be associated with the ARI capability of increasing brain-derived neurotrophic factor (BDNF) levels. Moreover, in the animals with nVHL, ARI attenuated the immunoreactivity for some oxidative stress-related molecules such as the nitric oxide synthase 2 (NOS-2), 3-nitrotyrosine (3-NT), and cyclooxygenase 2 (COX-2), as well as the reactive astrogliosis in the mPFC. These results contribute to current knowledge about the neurotrophic, anti-inflammatory, and antioxidant properties of antipsychotics which may be contributing to their clinical effects and envision promising therapeutic targets for the treatment of schizophrenia.


Subject(s)
Antipsychotic Agents , Animals , Rats , Antipsychotic Agents/pharmacology , Aripiprazole/pharmacology , Aripiprazole/therapeutic use , Animals, Newborn , Hippocampus , Prefrontal Cortex
2.
Synapse ; 75(2): e22185, 2020 02.
Article in English | MEDLINE | ID: mdl-32779216

ABSTRACT

Aging is a complex process that can lead to neurodegeneration and, consequently, several pathologies, including dementia. Physiological aging leads to changes in several body organs, including those of the central nervous system (CNS). Morphological changes in the CNS and particularly the brain result in motor and cognitive deficits affecting learning and memory and the circadian cycle. Characterizing neural modifications is critical to designing new therapies to target aging and associated pathologies. In this review, we compared aging to the changes occurring within the brain and particularly the limbic system. Then, we focused on key natural compounds, apamin, cerebrolysin, Curcuma longa, resveratrol, and N-PEP-12, which have shown neurotrophic effects particularly in the limbic system. Finally, we drew our conclusions delineating future perspectives for the development of novel natural therapeutics to ameliorate aging-related processes.


Subject(s)
Aging/drug effects , Limbic System/drug effects , Neurons/drug effects , Neuroprotective Agents/pharmacology , Nootropic Agents/pharmacology , Aging/metabolism , Amino Acids/pharmacology , Animals , Apamin/pharmacology , Curcuma , Limbic System/metabolism , Neuronal Plasticity/drug effects , Neurons/metabolism , Plant Extracts/pharmacology , Rats , Resveratrol/pharmacology
3.
Synapse ; 74(11): e22177, 2020 11.
Article in English | MEDLINE | ID: mdl-32531811

ABSTRACT

Recent reports on brain aging suggest that oxidative stress and inflammatory processes contribute to aging. Interestingly, sodium phenylbutyrate (PBA) is an inhibitor of histone deacetylase, which has anti-inflammatory properties. Several reports have suggested the effect of PBA on learning and memory processes, however there are no studies of the effect of this inhibitor of histone deacetylase on aging. Consequently, in the present study, the effect of PBA was studied in 18-month-old mice. The animals were administered PBA for 2 months after locomotor activity treatment and Morris water maze tests were performed. The Golgi-Cox staining technique and immunohistochemistry for glial fibrillary acidic protein (GFAP) and synaptophysin were performed for the morphological procedures. The administration of PBA improves learning and memory according to the Morris water maze test compared to vehicle-treated animals, which had unchanged locomotor activity. Using Golgi-Cox staining, dendritic length and the number of dendritic spines were measured in limbic regions, such as the nucleus accumbens (NAcc), prefrontal cortex (PFC) layer 3, and the CA1 of the dorsal hippocampus. In addition, PBA increased the number of dendritic spines in the PFC, NAcc, and CA1 subregions of the hippocampus with an increase in dendritic length only in the CA1 region. Moreover, PBA reduced the levels of the GFAP and increased the levels of synaptophysin in the studied regions. Thus, PBA can be a useful pharmacological tool to prevent or delay synaptic plasticity damage and cognitive impairment caused by age.


Subject(s)
Aging/drug effects , Hippocampus/drug effects , Neuroprotective Agents/pharmacology , Nucleus Accumbens/drug effects , Phenylbutyrates/pharmacology , Prefrontal Cortex/drug effects , Aging/metabolism , Aging/pathology , Animals , Dendritic Spines/drug effects , Dendritic Spines/physiology , Glial Fibrillary Acidic Protein/metabolism , Hippocampus/growth & development , Hippocampus/metabolism , Maze Learning , Mice , Neuronal Plasticity , Nucleus Accumbens/growth & development , Nucleus Accumbens/metabolism , Prefrontal Cortex/growth & development , Prefrontal Cortex/metabolism , Synaptophysin/metabolism
4.
Pathophysiology ; 24(4): 267-274, 2017 Dec.
Article in English | MEDLINE | ID: mdl-28712861

ABSTRACT

The aim of this study was to investigate the utility of the Golgi-Cox method to characterize the distribution and morphological changes of the hepatic stellate cells (HSCs) in CCl4 liver damaged rats. Six-week-old male Wistar rats were injected with CCl4 for ten weeks. The livers were processed with the Golgi-Cox method, reticuline, and Massons Trichrome stains, and analyzed under light microscopy. Histological evaluation of livers was made through the METAVIR score. In normal livers, the HSCs show stellate form with abundant thin cytoplasmic processes, distributed into hepatic lobule, mainly in zone 1. In addition, an intricate and broad network of fibers with radial distribution from the central vein to the periphery of the hepatic lobule was observed. In CCl4 damaged livers, with METAVIR score I and II, HSCs showed a moderate increase in the soma size, in the cytoplasmic processes and in density, distributed in zone 2 and 3; changes associated with a decrease in network fibers. In livers with METAVIR score III and IV, the morphology changes of the HSCs consisted of a significant increase in the soma size, cut and fraying appearance of the emerging cytoplasmic processes, and a decrease in HSCs density, distributed mainly in zone 3, with a significant depletion of network fibers. Results show that Golgi-Cox stain is able to impregnate the HSCs and could be an additional tool to study the morphological changes of the HSCs in the different experimental pathological conditions of the liver.

5.
Synapse ; 70(5): 198-205, 2016 May.
Article in English | MEDLINE | ID: mdl-26789133

ABSTRACT

Vascular dementia is a devastating disorder not only for the patient, but also for the family because this neurocognitive disorder breaks the patient's independence, and leads to family care of the patient with a high cost for the family. This complex disorder alters memory, learning, judgment, emotional control and social behavior and affects 4% of the elderly world population. The high blood pressure or arterial hypertension is a major risk factor for cerebrovascular disease, which in most cases leads to vascular dementia. Interestingly, this neurocognitive disorder starts after long lasting hypertension, which is associated with reduced cerebral blood flow or hypoperfusion, and complete or incomplete ischemia with cortical thickness. Animal models have been generated to elucidate the pathophysiology of this disorder. It is known that dendritic complexity determines the receptive synaptic contacts, and the loss of dendritic spine and arbor stability are strongly associated with dementia in humans. This review evaluates relevant data of human and animal models that have investigated the link between long-lasting arterial hypertension and neural morphological changes in the context of vascular dementia. We examined the effect of chronic arterial hypertension and aged in vascular dementia. Neural dendritic morphology in the prefrontal cortex and the dorsal hippocampus and nucleus accumbens after chronic hypertension was diskussed in the animal models of hypertension. Chronic hypertension reduced the dendritic length and spine density in aged rats.


Subject(s)
Dementia, Vascular/pathology , Dendrites/pathology , Hypertension/pathology , Animals , Dementia, Vascular/etiology , Dendrites/metabolism , Hippocampus/blood supply , Hippocampus/metabolism , Hippocampus/pathology , Humans , Hypertension/complications , Prefrontal Cortex/blood supply , Prefrontal Cortex/metabolism , Prefrontal Cortex/pathology
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