ABSTRACT
Background: The current gold standard and the first line of treatment for non-melanoma skin cancer is surgical excision. Nevertheless, some patients are not good candidates for surgery when wound healing may be impaired.Methods: A 96-year-old male presented with 1.2 cm by 1.5 cm tumoral lesion with an ill-infiltrated border and central ulceration located on the mid right lower leg. Biopsy confirmed the diagnosis of squamous cell carcinoma (SCC) in situ. The primary lesion was treated centrally to peripherally with multiple intralesional injections of 1.5 mL 5-Fluorouracil (5-FU) (50 mg/mL). The lesion was also treated with a single layer application of 80% Trichloroacetic acid (topical solution). One additional and final treatment of only 80% TCA was performed after three weeks.Results: There was a complete regression of the SCC three weeks after the second treatment.Conclusions: We demonstrate a case of SCC successfully treated with intralesional 5-FU and topical Trichloroacetic acid. Additionally, the SCC in situ was successfully cleared in two treatment sessions with the lowest cumulative dose of 5-FU reported. Intralesional injections of 5-FU and subsequent topical Trichloroacetic acid may be an effective option for patients with SCC who are not eligible for cutaneous surgery.
Subject(s)
Antimetabolites, Antineoplastic/therapeutic use , Carcinoma, Squamous Cell/drug therapy , Caustics/therapeutic use , Fluorouracil/therapeutic use , Skin Neoplasms/drug therapy , Trichloroacetic Acid/therapeutic use , Administration, Topical , Aged, 80 and over , Carcinoma, Squamous Cell/pathology , Drug Therapy, Combination , Humans , Injections, Intralesional , Male , Skin Neoplasms/pathology , Treatment OutcomeABSTRACT
BACKGROUND: Acne vulgaris is a chronic, multifactorial inflammatory skin disease involving the pilosebaceous unit. The prevalence of acne is high during adolescence and is known to persist into adulthood; however, the characteristics of adult acne have not been well established. In the adult population, acne has been associated with psychosocial repercussions impacting the quality of life of those who suffer it, especially in female patients. METHODS: This study assessed the demographic and clinical characteristics of 1,384 patients between the ages of 25 and 60 years from 21 countries in Latin America and the Iberian Peninsula, with the purpose of identifying parameters for the severity of the disease, its links to demographic, biological, social, and environmental factors, and potential triggers. RESULTS: Gender differences in severity and location of the lesions were identified. In a univariate analysis, the male gender, use of cosmetics, age of onset of adolescence, and signs of hyperandrogenism were associated with acne severity. CONCLUSIONS: The characteristics of adult acne may vary from those of adolescent acne, although the disease presentations are generally similar. Further research is needed to establish similarities and differences in manifestations of adult acne versus adolescent acne.
Subject(s)
Acne Vulgaris/epidemiology , Cosmetics/adverse effects , Hyperandrogenism/epidemiology , Quality of Life , Acne Vulgaris/diagnosis , Acne Vulgaris/etiology , Acne Vulgaris/psychology , Adult , Age Factors , Age of Onset , Female , Humans , Hyperandrogenism/complications , Hyperandrogenism/diagnosis , Latin America/epidemiology , Male , Prevalence , Prospective Studies , Risk Factors , Severity of Illness Index , Sex Factors , SkinABSTRACT
Acne is a common disease among patients with Latin American ancestry. Its presentation is very similar to that in all skin types, but nodulocystic acne is more frequent in patients with oily and darker skin than in white Caucasians. Acne sequelae in patients with Latin American ancestry and with darker skin include postinflammatory hyperpigmentation (PIH) and atrophic and hypertrophic scars or keloids, with PIH being the most common complication affecting the quality of life of patients. Lately, more attention has been paid to rosacea in patients with darker skin. It has been seen that some of the patients, especially women, diagnosed with adult acne and who did not respond to treatment, were actually patients with rosacea. It is important to recognize the clinical characteristics of this disease in patients with darker skin in whom erythema and telangiectasia are difficult to observe. Here, we present the most relevant clinical characteristics of both diseases, as well as their treatment in patients with darker skin with Latin American ancestry. J Drugs Dermatol. 2019;18(3 Suppl):s124-126.
Subject(s)
Acne Vulgaris/therapy , Dermatologic Agents/therapeutic use , Hispanic or Latino , Rosacea/therapy , Acne Vulgaris/complications , Acne Vulgaris/diagnosis , Acne Vulgaris/ethnology , Administration, Cutaneous , Administration, Oral , Cicatrix, Hypertrophic/ethnology , Cicatrix, Hypertrophic/etiology , Cicatrix, Hypertrophic/prevention & control , Cosmeceuticals/therapeutic use , Cryosurgery , Dermabrasion/methods , Female , Humans , Hyperpigmentation/etiology , Hyperpigmentation/prevention & control , Laser Therapy/methods , Male , Quality of Life , Rosacea/complications , Rosacea/diagnosis , Rosacea/ethnology , Sex Factors , Skin Pigmentation/drug effects , Skin Pigmentation/physiology , Sunlight/adverse effects , Sunscreening Agents/administration & dosage , United StatesABSTRACT
Acne is a chronic, immune-mediated, inflammatory disease with high prevalence among adolescents. By compromising face, thorax and back, with the risk of permanent scars, it has a negative impact on the quality of life. Effective, safe and early treatment is the key to remission, while decreasing the risk of physical and/or emotional sequelae. The Iberian-Latin American Group of Acne Studies joined professionals with expertise and developed a practical therapeutic algorithm, adapted to the reality of Latin American countries, Spain and Portugal. This article intends to disseminate it with an updated review on a rational, safe and effective acne treatment.
Subject(s)
Acne Vulgaris/therapy , Algorithms , Consensus , Humans , Latin America , Portugal , SpainABSTRACT
Abstract: Acne is a chronic, immune-mediated, inflammatory disease with high prevalence among adolescents. By compromising face, thorax and back, with the risk of permanent scars, it has a negative impact on the quality of life. Effective, safe and early treatment is the key to remission, while decreasing the risk of physical and/or emotional sequelae. The Iberian-Latin American Group of Acne Studies joined professionals with expertise and developed a practical therapeutic algorithm, adapted to the reality of Latin American countries, Spain and Portugal. This article intends to disseminate it with an updated review on a rational, safe and effective acne treatment.
