ABSTRACT
BACKGROUND: The aim of this study was to investigate the distribution of the regional cerebral blood flow (rCBF) in occupational-related post-traumatic stress disorder (PTSD) subjects and to seek possible correlations between brain perfusion and self-rating scales (SRS) in order to cross-check their diagnostic value and to look for their neural correlates. METHOD: A total of 13 traumatized underground and long-distance train drivers developing (S) and 17 not developing (NS) PTSD who had experienced a 'person under train' accident or who had been assaulted at work underwent clinical assessment and 99mTc-HMPAO SPECT imaging during autobiographical trauma scripts. Statistical parametric mapping was applied to analyse rCBF changes in S as compared with NS and to search for correlations between rCBF and the administered SRS scores, modelling age, months to SPECT and the ratio 'grey matter/intra-cranial volume' as nuisance variables. RESULTS: Significantly higher activity was observed during trauma script in left posterior and anterior insula, posterior cingulate, inferior parietal lobule, precuneus, caudate and putamen in PTSD subjects as compared with the trauma-exposed control group. Impact of Event Scale and World Health Organisation (10) Well-Being Index scores highly correlated with tracer uptake to a great extent in the same regions in which rCBF differences between S and NS were found. CONCLUSIONS: These findings support the involvement of insular, cingulate and parietal cortices (as well as the basal ganglia) in the pathogenesis of PTSD and in the processing of related subjective well-being and distress.
Subject(s)
Cerebrovascular Circulation/physiology , Self Report , Stress Disorders, Post-Traumatic/diagnosis , Accidents/psychology , Adult , Case-Control Studies , Crime Victims/psychology , Female , Humans , Interview, Psychological , Male , Psychometrics , Railroads , Stress Disorders, Post-Traumatic/physiopathology , Stress Disorders, Post-Traumatic/psychology , Tomography, Emission-Computed, Single-PhotonABSTRACT
Se analizan los aspectos clínicos, el tratamiento quirúrgico y los resultados de 16 casos consecutivos de Megacolon tóxico como complicación de la rectocolitis ulcerosa, atendidos en la I Clínica Quirúrgica de la Universidad de Roma, en el período 1976-1987. La cirugía realizada fue la colectomía total con ileorecto-anastomosis en un solo tiempo, sin ileostomía de protección, en 14 pacientes y colectomía con ileostomía terminal e ileorectoanastomosis diferida, cinco meses más tarde, en 2 pacientes no tuvimos mortalidad operatoria, las complicaciones inmediatas fueron: dehiscencia parcial de la anastomosis en un caso, proctorragia en tres casos. Las tardías fueron: fistulización y perforación del "cul de sac" ileal, en 2 casos. En un paciente 10 meses más tarde fue necesaria la protectomía por intensa reaquidización de la enfermedad a nivel rectal, sobre la base de los resultados obtenidos, en casos seleccionados proponemos: La colectomía total con ileorectoanastomosis inmediata como tratamiento de esta grave complicación
