ABSTRACT
Cheyne-Stokes respiration (CSR) during sleep is common in patients with congestive heart failure (CHF). This pattern of breathing fragments sleep, leading to daytime symptoms of sleepiness and fatigue. It was hypothesized that by controlling CSR with noninvasive pressure preset ventilation (NPPV), there would be a decrease in sleep fragmentation and an improvement in sleep quality. Nine patients (eight males, one female; mean +/- SD 65 +/- 11 yrs) with symptomatic CSR diagnosed on overnight polysomnography (apnoea/hypopnoea index (AHI) 49 +/- 10 x h(-1), minimum arterial oxygen saturation (Sa,O2, 77 +/- 7%) and CHF (left ventricular ejection fraction 25 +/- 8%) were studied. After a period of acclimatization to NPPV (variable positive airway pressure (VPAP) II ST, Sydney, NSW, Australia and bilevel positive airway pressure (BiPAP), Murraysville, PA, USA), sleep studies were repeated on therapy. NPPV almost completely abolished CSR in all patients with a reduction in AHI from 49 +/- 10 to 6 +/- 5 x h(-1) (p<0.001). Residual respiratory events were primarily due to upper airway obstruction at sleep on-set. Arousal index was markedly decreased from 42 +/- 6 to 17 +/- 7 x h(-1) (p <0.001). Sleep architecture showed a trend toward improvement with a reduction in stage 1 and 2 (79 +/- 7% during the diagnostic night versus 72 +/- 10% during NPPV, (p=0.057)), whilst sleep efficiency, slow-wave sleep (SWS), and rapid eye movement (REM) were not altered. Controlling Cheyne-Stokes respiration with noninvasive pressure preset ventilation resulted in reduced arousal and improved sleep quality in the patients with congestive heart failure. Noninvasive pressure preset ventilation should be considered a potential therapy for Cheyne-Stokes respiration in congestive heart failure in those patients who do not respond or fail to tolerate nasal continuous positive airway pressure therapy.
Subject(s)
Cheyne-Stokes Respiration/therapy , Heart Failure/therapy , Positive-Pressure Respiration/methods , Sleep Apnea Syndromes/therapy , Aged , Airway Resistance/physiology , Cheyne-Stokes Respiration/physiopathology , Female , Heart Failure/physiopathology , Humans , Male , Middle Aged , Polysomnography , Pulmonary Ventilation/physiology , Sleep Apnea Syndromes/physiopathology , Treatment OutcomeABSTRACT
The mechanisms leading to hypoxemia during sleep in patients with respiratory failure remain poorly understood, with few studies providing a measure of minute ventilation (V I) during sleep. The aim of this study was to measure ventilation during sleep in patients with nocturnal desaturation secondary to different respiratory diseases. The 26 patients studied had diagnoses of chronic obstructive pulmonary disease (COPD) (n = 9), cystic fibrosis (CF) (n = 2), neuromusculoskeletal disease (n = 4), and obesity hypoventilation syndrome (OHS) (n = 11). Also reported are the results for seven normal subjects and seven patients with effectively treated obstructive sleep apnea (OSA) without desaturation during sleep. Ventilation was measured with a pneumotachograph attached to a nasal mask. In the treated patients with OSA and in the normal subjects, only minor alterations in V I were observed during sleep. In contrast, mean V I for the group with nocturnal desaturation decreased by 21% during non-rapid-eye-movement (NREM) sleep and by 39% during rapid-eye-movement (REM) sleep as compared with wakefulness. This reduction was due mainly to a decrease in tidal volume (V T). Hypoventilation was most pronounced during REM sleep, irrespective of the underlying disease. These data indicate that hypoventilation may be the major factor leading to hypoxia during sleep, and that reversal of hypoventilation during sleep should be a major therapeutic strategy for these patients.
Subject(s)
Circadian Rhythm , Oxygen/blood , Respiration , Sleep/physiology , Adult , Aged , Cystic Fibrosis/blood , Cystic Fibrosis/physiopathology , Female , Humans , Hyperventilation/blood , Hyperventilation/physiopathology , Lung Diseases, Obstructive/blood , Lung Diseases, Obstructive/physiopathology , Male , Middle Aged , Musculoskeletal Diseases/blood , Musculoskeletal Diseases/physiopathology , Neuromuscular Diseases/blood , Neuromuscular Diseases/physiopathology , Obesity/blood , Obesity/physiopathology , Reference Values , Sleep Stages/physiology , Syndrome , Tidal Volume/physiologyABSTRACT
Lesions of the septum in animal subjects are known to produce an increase in aggressiveness and an increase in water intake. A series of experiments was carried out to examine the possibility that aggression was secondary to hyperdipsia. When rats with septal lesions were restricted to preoperative levels of water intake, aggression scores declined significantly. When animals without lesions were preloaded, with either water or saline, aggression increased. Neither decreased shock threshold nor increased cell hydration provided a full explanation for the results. It is suggested that the aversive nature of the stomach turgescence caused by increased water intake may be an additional mediating factor in septal aggression.
Subject(s)
Aggression/physiology , Drinking , Septum Pellucidum/physiology , Animals , Electroshock , Female , Humans , Rats , Sensory Thresholds , Water Deprivation , Water-Electrolyte BalanceABSTRACT
Many cyclic changes during the menstrual cycle (temperature, depression, motor activity, pain sensitivity, etc.) are closely paralleled by changes in brain serotonin level. These changes, in turn, are associated with peripheral hormone levels which are comparatively regular and easily measured. Their measurement may be useful both in predicting behavior and in accounting for atypical menstrual-related behavior.
Subject(s)
Behavior/physiology , Brain/metabolism , Menstruation , Serotonin/physiology , Body Temperature , Depression/etiology , Female , Humans , Monoamine Oxidase/metabolism , Motor Activity/physiology , Pain/physiopathology , Serotonin/metabolism , Sexual Behavior/physiologyABSTRACT
The authors describe a program based on a biopsychosocial model of illness, which uses a liaison-consultation approach in an outpatient setting. It is directed toward integrating psychiatric education and services with primary care in a health maintenance organization. This program can serve as a useful model for studying the validity and effectiveness of integrating psychiatric concepts with primary health care.
Subject(s)
Education, Medical, Graduate , Health Maintenance Organizations , Primary Health Care , Psychiatry , Referral and Consultation , Adult , Child, Preschool , District of Columbia , Female , Humans , Internship and Residency , Middle Aged , Models, TheoreticalABSTRACT
Slides were made from Munsell color chips in three sizes, four hues, and two chromas; all had the same intensity. A direct-comparisons, forced-choice procedure was used with 100 male and female volunteers from psychology courses. When pairs of slides had the same size and chroma, the order of decreasing apparent size was red-purple, yellow-red, purple-blue, and green. At chroma/8, all comparisons were significant except yellow-red over purple-blue. At chroma/4, the same order was found, but the effect was not pronounced. When pairs were made up of identical hues but different chromas, the square with chroma/4 (less saturation) appeared significantly larger.
Subject(s)
Color Perception , Illusions , Optical Illusions , Size Perception , Female , Humans , Male , Sex Factors , Visual PerceptionSubject(s)
Behavior, Animal/drug effects , Wine/analysis , Alcohol Drinking , Animals , Electroshock , Ethanol/pharmacology , Male , Motor Activity/drug effects , RatsSubject(s)
Pain , Water-Electrolyte Balance , Animals , Conditioning, Operant/physiology , Drinking Behavior/physiology , Male , Rats , Water DeprivationABSTRACT
Daily administration of alcohol did not affect the total response rate of rats on a DRL task although alcohol-treated animals made fewer correct (reinforced) responses than did controls.
