Subject(s)
Anti-Infective Agents/therapeutic use , Hospitals, Private , Intensive Care Units , Protein C/therapeutic use , Recombinant Proteins/therapeutic use , Sepsis/drug therapy , Anti-Infective Agents/economics , Critical Care , Humans , Protein C/economics , Recombinant Proteins/economics , South AfricaABSTRACT
Organophosphate insecticides may cause serious poisoning either accidentally or by deliberate ingestion. Toxic symptoms are produced by acetylcholine accumulation at cholinergic receptors. Diagnosis is based on history of exposure or ingestion, symptoms and signs of cholinergic overactivity and a decrease in serum pseudocholinesterase levels. Following diagnosis, grading of disease severity may identify patients with serious poisoning who should receive treatment in intensive care using adequate doses of anticholinergic drugs. Complications, particularly ventricular arrhythmias, central nervous system depression or seizures, and respiratory failure, should be anticipated and treated. Relapse may occur after seemingly successful treatment. Public education with regard to symptoms of toxicity must be encouraged, and physicians must provide skilled treatment for a potentially lethal condition.
Subject(s)
Carbamates/poisoning , Insecticides/poisoning , Organophosphorus Compounds , Humans , Poisoning/diagnosis , Poisoning/physiopathology , Poisoning/therapy , Severity of Illness IndexABSTRACT
Colposcopically directed punch biopsy specimens of the uterine cervix were taken from women in whom Papanicolaou smears indicated cytological abnormalities. Half of each specimen was processed for scanning electron microscopy and half for light microscopy. The surface morphology of normal cervical, metaplastic and frankly carcinomatous epithelia and epithelia of carcinoma in situ, as seen under the scanning electron microscope, was compared with the appearance revealed by Papanicolaou smears, and haematoxylin- and eosin-stained sections.
