ABSTRACT
Factors that influence the induction of anaesthesia with propofol were investigated in a prospective study of 1000 patients. Pre-operative albumin and urea concentrations correlated with the minimum induction dose of propofol, but less strong correlations were found with haemoglobin, globulin and total protein concentrations. Age was an important influence on the induction dose of propofol (r = -0.34) which was also closely related to ASA grade. Induction of anaesthesia with propofol is dependent on a number of variables, and this study suggests that pre-operative albumin and urea concentrations are important.
Subject(s)
Anesthesia, Intravenous , Propofol/administration & dosage , Adolescent , Adult , Age Factors , Blood Proteins/analysis , Female , Hemoglobins/analysis , Humans , Male , Prospective Studies , Serum Albumin/analysis , Serum Globulins/analysis , Severity of Illness Index , Urea/bloodABSTRACT
A reversed-phase ion-pairing HPLC method is developed for bitolterol mesylate (Tornalate, Winthrop-Breon) in aerosol dosage forms. Using data acquired by this method during a two-year period, the effect of ODS-3 column age on system suitability parameters is assessed. A BASIC program is used to calculate the resolution factor between bitolterol and colterol triester, capacity factors, number of theoretical plates, and tailing factors in studies that followed the performance of one column during this time period and five columns of different ages under normal usage. A 15 to 30% reduction in column performance per year is found.
