[Determination of after care periods for cancer patients]. / Opredelenie srokov "dolechivaniia" u onkologicheskikh bol'nykh.

Following an analysis of case histories of in-patients treated for tumors of the stomach and cervix uteri at the clinics of the Center in 1979, an assessment of the work put in by the personnel at different stages of their treatment and on the basis of interviews with the clinics' chiefs it was found that the establishment of an optimal period of postoperative treatment of tumor in-patients is impracticable. Due to a high degree of tumor specialization and a wide range of tumor sites, the establishment of specialized clinics or hospitals may face additional difficulty in selecting admissions and running wards with variable turnover of in-patients and highly-specialized personnel.

[Effect of phenazepam on the ethanol demand of rats]. / Vliianie fenazepama na potreblenie étanola krysami.

The new Soviet tranquilizer phenazepam given to rats intraperitoneally at a dose of 1 mg/kg daily was shown to be capable of suppressing ethanol addiction produced by 2-month intake of 5% ethanolic solution as the only source of liquid. The mechanism of this effect is likely to be related to the changes in the activity of the neurosecretory centers of the hypothalamus. The phenazepam in the treatment of chronic alcoholism.

[Differential diagnosis of esophageal cancer by using mathematical decision rules]. / Differentsial'nsaia idiagnostika raka pishchevoda pri ispol'zovanii matematicheskikh reshaiushikh pravil.

It is suggested to use the medico-mathematical "decisive rules" for the differential diagnosis of esophageal cancer in non-specialized medical institutions. As the first step the examination cards were written, based on the data of 1195 patients with verified diagnosis. The "decisive rules" were worked out basing on the examination cards of 597 patients (in 267--esophageal cancer and in 330--benign lesions: cardiospasm, benign tumors, cysts, burn and scarring strictures, esophagitis, diverticulum). The suggested "decisive rules" using 63 and 87 clinical signs were tested elsewhere for a retrospective diagnosis in 167 patients. Using the "decisive rules" with 63 clinical signs esophageal cancer was recognized in 96% of cases, non-cancer--in 92%, while using 87 signs--in 92 and 94% accordingly. The rule comprising 63 signs-questions is recommended for practical purposes.

[Preventive effect of lithium chloride on the development in rats of a preference for ethanol]. / Preventivnyi éffekt khlorida litiia na razvitie u krys predpochteniia k étanolu.

It was revealed in experiments on rats treated with a 5% ethanol solution with equal quantities of LiCl (experiment) and NaCl (control) for seven weeks as the only source of liquid that with li+ concentration in the blood plasma of approximately 0.6 meq/1 LiCl prevented the development of alcohol dependence. On studying the neurosecretory hypothalamic nuclei, hypophysis and adrenal cortex of the same animals a certain correlation has been demonstrated between the morphofunctional condition of the mentioned formations, the degree of ethanol preference development and the character of LiCl influence on the process.

[Effect of lithium chloride on ethanol uptake by rats]. / Vliianie khlorida litiia na potreblenie étanola krysami.

A selective uptake of ethanol by presenting its 5% solution as the only source of fluid was elaborated in rats for 2 months. It was found that lithium chloride injected intravenously in a dose of 35 mg/kg twice per 24 hours for 14 days depressed the ethanol preference causing a motivation inversion whose mechanism was associated with the changes in the activity of the hypothalamic centres of the neuroendocrine regulation. A possibility of lithium salts in the therapy of chronic alcoholism is discussed.

[Short-term spatial memory in mice]. / Kratkovremennaia prostranstvennaia pamiat' u myshei.

White mice were presented with two visually identical small cups, one containing a sugar solution, and the other a salt solution. After having once rejected in the course of search for sugar the cup with salt, the mice did not as a rule inspect it the second time, as is usually done by melliferous bees. With three of four cups, of which one contained a sugar solution, and the rest of salt solution, the number of repeated examinations sharply increased, still it did not attain that made by melliferous bees with the same number of objects. Hence, for the given class of problems, the behaviour of mice is superior to that of bees.

[Polysensory interaction in the cat posterior ventrolateral thalamic nucleus]. / Polisensornoe vzaimodeistvie v zadnem ventro-lateralsnom iadre talamusa koshki

The neurone activity was studied in the posterior ventrolateral nucleus of the thalamus in acute experiments on unanesthetized cats. About 20% of the neurons studied proved to react to the visual and somatosensory stimulation. By the character of reaction to these stimuli the polymodal neurons could be divided into three groups. In elaboration of the active defense reflex to visual electric skin stimulation there were recorded in the mentioned nucleus the rhythm assimilation reaction with the action of the flickering light and its depression in case a biologically significant stimulus was presented against this background. After section of the optic tract and separation of the hemispheres to the cerebellar level the rhythm assimilation reaction and its depression were revealed in the posterior ventro-lateral nucleus of the thalamus at the side of the section of the optic tract. This fact indicated that the leading canal of the entrance of visual afferentation to this nucleus passed through the stem reticular formation.