[Suppression of influenza virus NP-protein mRNA translation in vitro with derivatives of an antisense oligonucleotide]. / Podavlenie transliatsii mRNK NP-belka virusa grippa in vitro proizvodnymi antismyslovogo oligonukleotida.

Inhibition of the influenza virus protein NP mRNA with derivatives of an antisense oligonucleotide complementary to the 5' terminus of the mRNA was investigated. The derivatives were prepared by conjugation of aromatic 2-chloroethylamine, cholesterol, porphyrin, and phenazine groups to the 5'-terminal phosphate of the oligonucleotide. The most efficient inhibitors were found to be the conjugates bearing the alkylating, cholesterol and phenaznium groups.

[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides]. / Podavlenie transliatsii in vitro mRNK belka M1 virusa grippa s pomoshch'iu antismyslovykh oligonukleotidov.

Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.